Risk factors for and prevention of human papillomaviruses (HPV), genital warts and cervical cancer

Chelimo, Carol; Wouldes, Trecia; Cameron, Linda D.; Elwood, J. Mark

doi:10.1016/j.jinf.2012.10.024

Cited by 246 publications

(225 citation statements)

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“…Women who has had first child at early age had smaller survival time. Similarly Similar finding was obtained from [37] reported having your first baby before the age of 16 gives a higher risk, compared to women who had their first baby after the age of 25.This result is also in accordance with the studies [38,39].…”

Section: Discussionsupporting

confidence: 91%

Assessing Survival Time of Women with Cervical Cancer Using Various Parametric Frailty Models: A Case Study at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Gurmu

2018

Ann. Data. Sci.

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Cervical cancer is one of the leading causes of death in the world and represents a tremendous burden on patients, families and societies. It is estimated that over one million women worldwide currently have cervical cancer; most of them have not been diagnosed or have no access to treatment that could cure them or prolong their lives. The goal of this study is to investigate potential risk factors affecting survival time of women with cervical cancer at Tikur Anbessa specialized hospital. Data were taken from patients' medical record card that enrolled during September 2011-September 2015. Kaplan-Meier estimation method, Cox proportional hazard model and parametric shared frailty model were used to analysis survival time of cervical cancer patients. Study subjects (cervical cancer patients) in this study came from clustered community and hence clustered survival data correlated at the regional level. Parametric frailty models will be explored assuming that women with in the same cluster (region for this study) shares similar risk factors. We used Exponential, Weibull, Log logistics and Log normal distributions and based on AIC criteria, all models were compared for their performance. The lognormal inverse Gaussian model has the minimum AIC value among the models compared. The results implied that not giving birth up to the study ends and married after twenty years were significantly prolong the survival time of patients while age class 51-60, 61-70, > 70, smoking cigarettes, patients with stage III and IV disease, family history of cervical cancer, history of abortion and living with HIV AIDS were significantly shorten survival time of patients. The findings of this study suggested that age, smoking cigarettes, stage, family history, abortion history, living with HIV AIDS, age at first marriage and age at first birth were major factors to survival time of patients. Heterogeneity between B Selamawit Endale Gurmu

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Section: Discussionsupporting

confidence: 91%

Assessing Survival Time of Women with Cervical Cancer Using Various Parametric Frailty Models: A Case Study at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Gurmu

2018

Ann. Data. Sci.

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“…Cervical cancer (CC), which is the third most common cause of cancer in women in the world, is mainly associated with infection by human papillomavirus (HPV), which is a small, circular, double-stranded DNA virus that is also associated with cervical neoplasia, anogenital warts and other anogenital cancers (1,2). According to previous reports from the International Agency for Research on Cancer, HPV could be classified into high-risk (HR) types (16,18,31,33,35,39,45, 51, 52, 56, 58, 59, 68, 73 and 82), probable HR types (26,53 and 66) and low-risk types (6,11,40,42,43,44,54,61,70,72, 81 and CP6108) (3).…”

Section: Introductionmentioning

confidence: 99%

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

Shi

Líu

et al. 2017

Oncol Lett

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Abstract. The present prospective study aimed to evaluate the effects of E6/E7 protein detection by western blotting on cervical cancer (CC) early screening compared with detection by Hybrid Capture 2 (HC2) test and ThinPrep cytological test (TCT) in a Chinese population. A total of 450 cases of cervical intraepithelial neoplasia (CIN) suspected samples (positive in ≥1 indicator of TCT and HC2 test) were recruited from women who were treated at the International Peace Maternity and Child Health Hospital (Shanghai, China) from March 2014 to February 2015. Each sample was analyzed by cytological test. In addition, human papillomavirus (HPV) DNA examination by Hybrid Capture Tube test and E6/E7 protein expression detection by western blotting were performed in all samples, as well as histologic diagnosis to determine the stage of CIN. The results revealed that, for the diagnosis of CIN2 + , although the sensitivity of E6/E7 protein detection was lower than that of HC2 test (71.3 vs. 96.6%, respectively), the specificity was markedly improved (67.6 vs. 5.9%, respectively). Compared with that of TCT, the sensitivity of E6/E7 protein detection was much higher (36.2 vs. 71.3%, respectively), but the specificity was lower (88.2 vs. 67.6%, respectively). In the present study, HPV E6/E7 protein expression was evaluated as a potential new biomarker for CC, with satisfactory diagnostic values for HPV types 16 and 18. The relative diagnostic value may be further improved by combination of E6/E7 messenger RNA detection.

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“…Also, HPV plays an etiological role in many vaginal, vulvar, anal, penile, as well as head and neck cancers (Gillison et al, 2012d;Moscicki et al, 2012). In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV, particularly HPV6 and 11 (Chelimo et al, 2013;Gillison et al, 2012c). Moreover, HPV detected in several other cancers including esophageal squamous cell carcinoma (Syrjanen, 2002b;Tornesello et al, 2009), lung 1 * (Rezazadeh et al, 2009b;Munoz et al, 2012), prostate (Lin et al, 2011), ovarian (Rosa et al, 2013), breast (Simoes et al, 2012), skin (Iftner et al, 2003), colorectal (Burnett-Hartman et al, 2008;Lorenzon et al, 2011) and urinary tract cancers (Li et al, 2011), but association of HPV to these cancers is controversial.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

Jalilvand¹,

Shoja²,

Hamkar³

2014

Asian Pacific Journal of Cancer Prevention

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Certain types of human papillomaviruses (HPVs) are undoubtedly involved in genesis of human malignancies. HPV plays an etiological role in cervical cancer, but also in many vaginal, vulvar, anal and penile cancers, as well as head and neck cancers. In addition, a number of non-malignant diseases such as genital warts and recurrent respiratory papillomatosis are attributable to HPV. Moreover, HPV forms have detected in several other cancers including esophageal squamous cell carcinoma, lung, prostate, ovarian, breast, skin, colorectal and urinary tract cancers, but associations with etiology in these cases is controversial. The aim of this systematic assessment was to estimate the prevalence of HPV infection and HPV types in HPV-associated cancers, HPV-related non-malignant diseases and in cancers that may be associated with HPV in Iran. The present investiagtion covered 61 studies on a variety of cancers in Iranian populations. HPV prevalence was 77.5 % and 32.4% in cervical cancer and head and neck cancers, respectively. HPV was detected in 23.1%, 22.2%, 10.4%, 30.9%, 14% and 25.2% of esophageal squamous cell, lung, prostate, urinary tract cancers, breast and skin cancers, respectively. HPV16 and 18 were the most frequent HPV types in all cancers. The findings of present study imply that current HPV vaccines for cervical cancer may decrease the burden of other cancers if they are really related to HPV.

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Risk factors for and prevention of human papillomaviruses (HPV), genital warts and cervical cancer

Cited by 246 publications

References 91 publications

Assessing Survival Time of Women with Cervical Cancer Using Various Parametric Frailty Models: A Case Study at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Assessing Survival Time of Women with Cervical Cancer Using Various Parametric Frailty Models: A Case Study at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

E6/E7 proteins are potential markers for the screening and diagnosis of cervical pre‑cancerous lesions and cervical cancer in a Chinese population

Human Papillomavirus Burden in Different Cancers in Iran: a Systematic Assessment

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