Risk factors for asthma in patients with allergic rhinitis in eastern China

Zhao, Li; Yang, Yan; Zang, Yi Ran; Zhang, Q.; Xu, Liang; Yuan, Guang Mei; Peng, Jin; Zi, Xiao; Yu, Ke Na; Zhang, Hai Ling; Li, Shi

doi:10.1016/j.amjoto.2022.103426

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…House dust mite was the foremost allergen in patients with allergic airway disease from South-western Maharashtra, a region from India [ 16 ]. It is a common allergen affecting several patients with AR from different parts of the world including India, Hong Kong, China, Ireland, Qatar, and Belgium [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. It has been reported as the most common allergen for AR [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of common allergens affecting patients with allergic rhinitis

2023

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Allergic rhinitis (AR) is an atopic disorder that affects the quality of life of the patients. AR symptoms include sneezing, nasal congestion, and mucus discharge. It is often associated with several other eye-, ear-, and nose-related symptoms along with fatigue and mood changes. The allergic reaction is triggered by an allergen. An understanding of the allergens that affect a patient is important for allergen avoidance, and ultimately, the treatment of AR. This study aimed to identify the common allergens affecting patients with AR. A total of 52 patients with AR were identified for this study. AR was diagnosed based on the presenting symptoms and measurement of IgE levels and absolute eosinophil counts. Skin prick tests (SPT) were performed to identify the allergen sensitivity of the patients. Patient history, family history, and a detailed account of the symptoms were recorded. Finally, correlation between family history and allergy severity was statistically evaluated. All patients presented symptoms of rhinitis with sinusitis and 61.5% of these were mild or moderate allergic. Few of the patients had ocular or otic symptoms. The duration of allergy was variable in these patients. A high proportion of patients were allergic to house dust mites (92.3%). The proportion of patients allergic to pollen, Parthenium, cockroach, cotton dust, and Aspergillus were 84.6%, 76.9%, 75%, 65.4%, and 61.5%, respectively. Around 71.2% of patients reported a family history of allergy. SPT severity was not associated with family history (p=0.266). This study successfully identifies the common allergens affecting patients with AR from Chennai, India. It highlights the importance of SPT for the identification of allergens in deciding the treatment regimen for AR.

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Section: Discussionmentioning

confidence: 99%

Analysis of common allergens affecting patients with allergic rhinitis

2023

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“…CCR3 monoclonal antibody (CCR3 mAb) [5][6][7][8][9] is a highly uniform antibody produced by a single B cell clone that targets speci cally to the CCR3 antigen epitope [10,11]. It is usually generated using hybridoma technology and can speci cally block the downstream effects of CCR3 on cells.…”

Section: Introductionmentioning

confidence: 99%

The study of the role of Purified anti-mouse CD193 (CCR3) Antibody in allergic rhinitis mouse animal models

Bao,

Wu,

Zhu

et al. 2023

Preprint

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The pathogenesis of allergic asthma is similar to that of allergic rhinitis, with inflammation cells producing and releasing inflammatory mediators and cytokines closely related to CCR3. Related literature has reported that the use of CCR3 monoclonal antibodies can improve symptoms such as allergic enteritis and allergic pneumonitis. Based on the theory of "one airway, one disease", the use of CCR3 monoclonal antibodies may also have a similar effect on allergic rhinitis. However, there are currently few research reports on the application of CCR3 monoclonal antibodies in allergic rhinitis. Therefore, this study aims to explore the effective concentration of CCR3 monoclonal antibodies and compare the effects of different dosing methods, as well as detecting the lung condition of allergic mice to investigate whether antibody treatment can protect the lungs. On the basis of successfully constructing a mouse model of allergic rhinitis, this study uses intraperitoneal injection of three different doses of CCR3 mAb (5uL/mg, 10uL/mg, and 20uL/mg) to observe its therapeutic effects: observing changes in tissue morphology of nasal mucosa, infiltration of inflammation, and using ELISA to detect changes in relevant inflammatory mediators and cytokines, studying the role of CCR3 mAb in inhibiting CCR3-related actions on the nasal mucosa of allergic rhinitis mice. Furthermore, based on the effective concentration, two dosing methods were compared: intraperitoneal injection and topical administration to study the therapeutic effects of both dosing methods.

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The study of the role of purified anti-mouse CD193 (CCR3) antibody in allergic rhinitis mouse animal models

Bao,

Wu,

Zhu

et al. 2024

Sci Rep

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The pathogenesis of allergic asthma is similar to that of allergic rhinitis, with inflammation cells producing and releasing inflammatory mediators and cytokines closely related to CCR3.Based on the theory of "one airway, one disease", the use of CCR3 monoclonal antibody may have a similar effect on allergic rhinitis. However, there are few studies on CCR3 monoclonal antibody in allergic rhinitis. Therefore, the aim of this study was to investigate the effective concentration of CCR3 monoclonal antibody, to compare the effects of different methods of administration, and to examine the lung condition of allergic mice to investigate whether antibody treatment protects the lungs. In this study, we constructed a mouse model of allergic rhinitis and intraperitoneally injected different doses of CCR3 monoclonal antibody (5, 10, and 20 uL/mg) to observe its therapeutic effect: observing changes in tissue morphology of nasal mucosa, infiltration of inflammation, and using ELISA to detect changes in relevant inflammatory mediators and cytokines, studying the role of CCR3 mAb in inhibiting CCR3-related actions on the nasal mucosa of allergic rhinitis mice. Furthermore, In addition, the therapeutic effects of intraperitoneal injection (i.p.) and intranasal administration (i.n.) were studied on the basis of effective concentrations.

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Risk factors for asthma in patients with allergic rhinitis in eastern China

Cited by 3 publications

References 25 publications

Analysis of common allergens affecting patients with allergic rhinitis

Analysis of common allergens affecting patients with allergic rhinitis

The study of the role of Purified anti-mouse CD193 (CCR3) Antibody in allergic rhinitis mouse animal models

The study of the role of purified anti-mouse CD193 (CCR3) antibody in allergic rhinitis mouse animal models

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