Risk factors for at-risk foot and peripheral artery disease among the population with diabetes: A multicommunity-based cross-sectional study

Ren, Bichen; Li, Bingzhe; Pan, Tianyue; Zhao, Enhui; Ju, Shuai; Li, Xiaoyan; Li, Xiaomu; Zhu, Yizhun; Cai, Yunmin; Huang, Lihong; Fu, Weiguo; Dong, Zhihui

doi:10.1016/j.diabres.2023.110869

Cited by 3 publications

(1 citation statement)

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“…Diabetes mellitus facilitates the progression of medial artery calcification, which increases the values of systolic pressure at the ankle, and thus, T2DM patients diagnosed with PAD via a Doppler ultrasound might have a falsely normal ABI [24]. TcPO2 measurement should be conducted to assess the ischemia grade in those with arterial calcification where ABI and TBI are unreliable, in those without clinical symptoms like claudication and rest pain, and in those with diabetic foot complications [26][27][28]. This is following our results where no significant relation between ABI and TcPO2 was observed in stage 4 of the Fontaine classification (in our case, 18 patients with neuropathic ischemic ulcers and 1 with gangrene).…”

Section: Discussionmentioning

confidence: 99%

In Association with Other Risk Factors, Smoking Is the Main Predictor for Lower Transcutaneous Oxygen Pressure in Type 2 Diabetes

Bulum,

Brkljačić,

Tičinović Ivančić

et al. 2024

Biomedicines

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Type 2 diabetes mellitus (T2DM) significantly increases the risk of peripheral artery disease (PAD), and diabetes is the leading cause of nontraumatic amputations. This study investigated the risk factors for transcutaneous oxygen pressure (TcPO2) in T2DM, a noninvasive method to quantify skin oxygenation and the underlying microvascular circulation. The study included 119 T2DM patients (91 male/28 female). TcPO2 measurements were conducted with the Tina TCM4 Series transcutaneous monitor (Radiometer, Copenhagen, Sweden) and skin electrodes. Patients with TcPO2 < 40 mmHg were younger (p = 0.001), had significantly higher systolic blood pressure (SBP) (p = 0.023), glycated hemoglobin (HbA1c) (p = 0.013), fasting plasma glucose (fPG) (p = 0.038), total cholesterol (p = 0.006), LDL cholesterol (p = 0.004), and had more frequent smoking habits (p = 0.001) than those with TcPO2 ≥ 40 mmHg. The main predictors for the TcPO2 value (R2 = 0.211) obtained via stepwise regression analysis were age, smoking, SBP, HbA1c, fPG, and total and LDL cholesterol. Among all the listed predictors, smoking, HbA1c, and LDL cholesterol were found to be the most significant, with negative parameter estimates of −3.051310 (p = 0.0007), −2.032018 (p = 0.0003), and −2.560353 (p = 0.0046). The results of our study suggest that in association with other risk factors, smoking is the main predictor for lower TcPO2 in T2DM.

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