Risk factors for autism spectrum disorder in the Thai population

Khaiman, Chusana; Onnuam, Kanchana; Photchanakaew, Siripraphar; Chonchaiya, Weerasak; Suphapeetiporn, Kanya

doi:10.1007/s00431-015-2544-2

Cited by 19 publications

(13 citation statements)

References 29 publications

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“…Similar to the US studies, higher SES was found to be a possible risk factor for autism in India, 11 but not in the UK 12 or in Thailand. 13 Additionally, parental education was also not associated with autism risk in the UK. 13 A Danish study showed no significant association between risk of autism on the one hand and SES and maternal education on the other hand (paternal education was not analyzed).…”

Section: Introductionmentioning

confidence: 99%

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Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

Hrdlička¹,

Vacova²,

Ošlejšková³

et al. 2016

NDT

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BackgroundThe marked increase in autism spectrum disorders (ASD) prevalence has stimulated worldwide interest in exploring broader circumstances of care of autistic children, including the role of socioeconomic status (SES) and family information on autism.MethodsOur sample comprised of 160 children who participated in a diagnostic examination focused on autism, and their parents who completed a simple descriptive questionnaire focusing on the family situation as well as family self-education about autism. The diagnosis of ASD was confirmed in 120 children (75% of the sample; 94 boys, 26 girls) with mean age 6.2±2.7 years (median 5.3, range 2.2–17.2 years). In 71 autistic patients (59.2%), a diagnosis of mental retardation was also established.ResultsThe age at diagnosis of ASD correlated negatively with maternal (P=0.014) and paternal (P=0.002) ages at the time of birth of the ASD child as well as with paternal (P=0.002) and maternal (P=0.050) education. The age at diagnosis of ASD did not correlate with family SES. Mothers were significantly more active in seeking information on autism than fathers or both parents equally (80 vs 9 vs 28 cases, respectively; P<0.001). The mean number of information sources on autism was 3.5±1.8 with a range 0–9. The mean number of resources did not differ among the three SES groups (3.50 vs 3.49 vs 4.25, respectively; P=0.704). The mean number of sources did not correlate with the age at diagnosis of ASD. The most often used sources were the Internet (81.7%), followed by psychologists (48.3%), books (46.7%), and child and adolescent psychiatrists (43.3%).ConclusionAn earlier diagnosis of ASD is associated with higher parental age at birth and higher parental education but not with family SES or number of family information sources.

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Section: Introductionmentioning

confidence: 99%

“… 13 Additionally, parental education was also not associated with autism risk in the UK. 13 A Danish study showed no significant association between risk of autism on the one hand and SES and maternal education on the other hand (paternal education was not analyzed). 14 However, markedly different results came from Sweden.…”

Section: Introductionmentioning

confidence: 99%

Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

Hrdlička¹,

Vacova²,

Ošlejšková³

et al. 2016

NDT

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“…In a research carried out by Boukhris et al, it was reported that depression during pregnancy and the use of antidepressants during the second and third trimester of pregnancy increased the risk of ASD in children (Boukhris et al, 2016). In another study conducted by Khaiman et al, it was reported that mental disorders of parents, family history of psychiatric disorders, and high age of the father were among the most important environmental risk factors for ASD (Khaiman et al, 2015). Based on the results of this research, the odds of autism in children of fathers of case group was higher than that of non-relative and relative control groups with the dimension of obsessive compulsive disorder.…”

Section: Discussionmentioning

confidence: 48%

Investigation of the Relationship between Parental Mental Disorders and Autism among the Children of West Azerbaijan -Iran

Equal¹,

Rasouli²,

Kiani³

2020

JMBR

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Background: Autism disorders have increased over the last years. Autism is a neurological growth disorder associated with social communication disorders, growth retardation, and repetitive behaviors, along with serious consequences for children and families. The purpose of this research was to evaluate the relationship between parental mental disorders and autism among the children of West Azerbaijan Province. Methods: This research was a case-control study in which the case group subjects were selected among the parents with autistic children and control group subjects were selected among the relative parents with healthy children and non-relative parents with healthy children. Both case and control groups were matched in terms of gender, living place, and age of children. Finally, the data were analyzed using SPSS-16 (Chicago, IL, USA) software. Results: The current research results revealed that the frequency of mental diseases, including obsessive-compulsive, inter personality sensitivity, depression, anxiety, hostility, phobia, paranoid ideation, and psychotic disorder are different in fathers and mothers of the case and control groups. As Pvalue was lower than 0.05 in all scales, there was a significant relationship between the mental diseases of parents and the history of mental disorders in relatives and autism. Conclusion: The prevalence of mental disorders in relatives and having a medical history can be a warning sign of autism in children.

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“…Some studies have also investigated the link between ASD in children and chronic inflammatory bowel disease in their parents, but the results are inconsistent, with two studies indicating a link (18,20) and the two largest studies showing no link (16,21). A study from Thailand also found no significant link between autoimmunity in parents and the development of ASD in their children (22); however, that report did not specify which diseases were included. The more-recent meta-analysis by Chen and colleagues included 9 large case-control studies and 1 cohort study covering 9,775 cases of ASD and 952,211 controls (23), and found a positive link between autoimmune diseases in the mother and the risk of ASD in the child.…”

Section: Some Studies Have Found An Increased Risk Of Asd In Childrenmentioning

confidence: 99%

Role of the Immune System in Autism Spectrum Disorders (ASD)

Ormstad

Bryn

Saugstad

et al. 2018

CNSNDDT

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We propose that the large inconsistencies in findings among studies in the field are due to differences in subdiagnoses among the included children with ASD. Well-phenotyped ASD samples are needed to understand the biological and immunological mechanisms underpinning ASD and its subdiagnoses. Future research should apply new strategies to scrutinize the link between ASD and changes in immune responsivity. Important new research avenues are to investigate the associations (a) between different ASD phenotypes and aberrations in (auto)immune pathways and (b) between reduced natural regulatory autoimmune responses during pregnancy, which are in turn associated with increased oxidative and nitrosative stress in maternal blood and putative detrimental effects in the offspring.

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Risk factors for autism spectrum disorder in the Thai population

Cited by 19 publications

References 29 publications

Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism?

Investigation of the Relationship between Parental Mental Disorders and Autism among the Children of West Azerbaijan -Iran

Role of the Immune System in Autism Spectrum Disorders (ASD)

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