Risk factors for bacterial vaginosis: results from a cross-sectional study having a sample of 53,652 women

Li, X.-D.; Wang, C.-C.; Zhang, X.-J.; Gao, Guopeng; Tong, Fei; Hou, Sai‐Mei; Sun, Lu; Sun, Yehuan

doi:10.1007/s10096-014-2103-1

Cited by 36 publications

(26 citation statements)

References 37 publications

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“…On this prospective study, 150 vaginal samples were used to compare BV diagnosis by the classic Nugent criteria and our PNA-FISH methodology. As shown in Table 1 , the main characteristics of the sample population used to validate our method mirrors what has been described in other main epidemiological studies, namely (1) the overall rate of positive BV cases (17%) in the general population ( Koumans et al, 2007 ; Li et al, 2014 ; Jespers et al, 2014 ), (2) an association between previous BV infections and BV positive diagnostic ( Bilardi et al, 2013 ; Guedou et al, 2013 ), (3) a higher risk factor for women using the pill instead of a condom ( Bradshaw et al, 2013 ; Guedou et al, 2013 ), and (4) the history of previous pregnancy being higher in women with BV ( Africa, Nel & Stemmet, 2014 ; Mengistie et al, 2014 ).…”

Section: Resultsmentioning

confidence: 75%

Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescencein situhybridization method

Machado

Castro

Cereija

et al. 2015

PeerJ

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Bacterial vaginosis (BV) is one of most common vaginal infections. However, its diagnosis by classical methods reveals low specificity. Our goal was to evaluate the accuracy diagnosis of 150 vaginal samples with research gold standard methods and our Peptide Nucleic Acid (PNA) probes by Fluorescence in situ Hybridization (FISH) methodology. Also, we described the first PNA-FISH methodology for BV diagnosis, which provides results in approximately 3 h. The results showed a sensitivity of 84.6% (95% confidence interval (CI), from 64.3 to 95.0%) and a specificity of 97.6% (95% CI [92.6–99.4%]), demonstrating the higher specificity of the PNA-FISH method and showing false positive results in BV diagnosis commonly obtained by the classical methods. This methodology combines the specificity of PNA probes for Lactobacillus species and G. vaginalis visualization and the calculation of the microscopic field by Nugent score, allowing a trustful evaluation of the bacteria present in vaginal microflora and avoiding the occurrence of misleading diagnostics. Therefore, the PNA-FISH methodology represents a valuable alternative for BV diagnosis.

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Section: Resultsmentioning

confidence: 75%

Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescencein situhybridization method

Machado

Castro

Cereija

et al. 2015

PeerJ

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“…12 We used population-based data from rural Bangladesh to determine prevalence and risk factors for AVF and estimated the association of persistent AVF with adverse pregnancy outcomes. 12 We used population-based data from rural Bangladesh to determine prevalence and risk factors for AVF and estimated the association of persistent AVF with adverse pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…One other large study in Asia did not include sexual risk factors and BV prevalence appeared to vary significantly by sociodemographic characteristics, ethnicity, intrauterine device use and variations in the menstrual cycle. 12 We used population-based data from rural Bangladesh to determine prevalence and risk factors for AVF and estimated the association of persistent AVF with adverse pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of and risk factors for abnormal vaginal flora and its association with adverse pregnancy outcomes in a rural district in north‐east Bangladesh

Baqui

Lee

Koffi

et al. 2018

Acta Obstet Gynecol Scand

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Abbreviations: AVF, abnormal vaginal flora; BVAB, bacterial vaginosis-associated bacteria; BV, bacterial vaginosis; CHW, community health worker; CI, confidence interval; OR, odds ratio; RR, relative risk. AbstractIntroduction: The role of screening and treatment for abnormal vaginal flora (AVF) on adverse pregnancy outcomes remains unclear. Using data from women who participated in a population-based cluster randomized trial who were screened and treated for AVF, we report risk factors for AVF and association of persistent AVF with adverse perinatal outcomes. Material and methods:Pregnant women (n = 4221) <19 weeks of gestation provided self-administered mid-vaginal swabs; smears were Nugent-scored. AVF was treated with oral clindamycin; if AVF was present 3 weeks after treatment, persistent AVF was re-treated. We examined risk factors for AVF and the association of persistent AVF with adverse pregnancy outcomes. Results:The prevalence of AVF was 16.5%: 9.8% of women had bacterial vaginosis and 6.8% had intermediate flora. Lower economic and educational status of women were associated with increased risk of AVF. One-third of women with AVF had persistent abnormal flora; these women had a higher risk of a composite measure of adverse pregnancy outcomes from 20 to <37 weeks (preterm live birth, preterm still birth, late miscarriage) (relative risk [RR] 1.33, 95% confidence interval [CI] 1.07-1.65) and of late miscarriage alone (RR 4.15,) compared to women without AVF. Conclusions:In this study in Sylhet District, Bangladesh, rates of AVF and persistent AVF were high and persistent AVF was associated with adverse pregnancy outcomes, with an especially high associated risk for late miscarriage. Further characterization of the microbiome and relative bacterial species density associated with persistent AVF is needed.

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“…It is a form of operation in the uterine cavity, so it has certain adverse effects, such as e.g. uterine infection, uterine bleeding, and uterine perforation [1][2][3][4]. The tailed IUD has a tail fiber attached to the end of the intrauterine device, which is kept to 2 cm outside the cervix for providing convenient access for the removal of IUD.…”

Section: Discussionmentioning

confidence: 99%

A study on the relationship between intrauterine device type and processing period and reproductive tract infections

Sun¹,

Guo

Li³

et al. 2019

THC

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The intrauterine device (IUD) has corresponding side effects including reproductive tract infectious diseases, irregular vaginal bleeding, menoxenia, lower abdominal pain, pain in the lumbosacral region and ectopic gestation. A prior study conducted by Bhatia and Cleland reflected that contraceptive usage was one of the factors that influence the occurrence of RTIs in South India. Although many studies have been conducted in various parts of different countries with the aim to document the prevalence of RTIs and its risk factors, there remains a lack of sizable literature for Chinese women who use specific IUDs. Therefore, we conducted an analysis on the relationship of IUD type and processing period with the occurrence rate of RTI.

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Risk factors for bacterial vaginosis: results from a cross-sectional study having a sample of 53,652 women

Cited by 36 publications

References 37 publications

Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescencein situhybridization method

Diagnosis of bacterial vaginosis by a new multiplex peptide nucleic acid fluorescencein situhybridization method

Prevalence of and risk factors for abnormal vaginal flora and its association with adverse pregnancy outcomes in a rural district in north‐east Bangladesh

A study on the relationship between intrauterine device type and processing period and reproductive tract infections

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