Risk Factors for Benign Breast Disease according to Histopathological Type: Comparisons with Risk Factors for Breast Cancer

Minami, Yuko; Ohuchi, Noriaki; Taeda, Yoshinori; Fukao, Akira; Hisamichi, Shigeru

doi:10.1111/j.1349-7006.1998.tb00538.x

Cited by 32 publications

(38 citation statements)

References 26 publications

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“…In the previous literature, we found a positive correlation between lactation duration and BBDs of proliferative type ( Minami et al 1998), but not between lactation history and BBDs in general (Minami et al 1998).…”

Section: Discussionmentioning

confidence: 99%

“…All the cellular elements of FA are normal, and epithelium and myoepithelium maintain a normal relationship (Courtillot et al 2005), but FAs are a proliferative benign breast disease and present a small increase in breast cancer (BC) risk (Santen and Mansel 2005;Minami et al 1998).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that breast-feeding and pregnancy are protective against malignant breast disease and are risk factors for BBD (Ma et al 2010;Minami et al 1998). In the literature, it is not clarifi ed if there is a correlation between breast-feeding and its duration with BBD.…”

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confidence: 99%

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Breast-feeding and benign breast disease

Bernardi

Londero

Bertozzi³

et al. 2011

Journal of Obstetrics and Gynaecology

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1992; McDivitt et al. 1992;Sarnelli and Squartini 1991;Kelsey and Gammon 1990).It is known that breast-feeding and pregnancy are protective against malignant breast disease and are risk factors for BBD (Ma et al. 2010;Minami et al. 1998). In the literature, it is not clarifi ed if there is a correlation between breast-feeding and its duration with BBD. Moreover, we have only little information about BBD aetiology and correlation to women ' s reproductive function, despite its high prevalence in the young female population. Th e objective of our study is to investigate the possible correlation between BBD and breast-feeding. Materials and methodsTh e series in this study consisted of women who presented to the Senology Outpatients Facility in our Department of Surgery during 2008, and a random control group of women who delivered in our Clinic of Obstetrics and Gynecology during 2008. Th is study was conducted according to the declaration of Helsinki, and with internal review board approval.Women were referred to our outpatients facility complaining of breast pain, discomfort or incidental clinical fi ndings. Among 355 women with a diagnosis of BBD, we chose to include those in their fertile age, under 40 years, with a histological diagnosis of BBD or a confi rmed BI-RADS 1 -2 (at least twice). We stated these selection criteria to minimise the possible inclusion of malignant pathologies. A total of 105 BBD and 98 controls were available for data analysis.Information on reproductive history (age at menarche, age at fi rst birth, age at last birth, history of abortion, parity, history of lactation for the last and previous children); medical history (histories of benign breast disease and gynaecological disease and family history of breast cancer); and other information (e.g. age, BMI, use of contraceptive or any other hormonal therapy) was collected by telephone interview, at routine outpatients visits or consulting clinical fi les of women aff ected by BBDs. In the control group, we collected the following information: age, parity, breast-feeding and its duration.Women aff ected by BBD were regrouped into two major categories according to their parity (nullipara and non-nullipara). We then divided the non-nulliparous group of women who breastfed, into two sub-groups based on breast-feeding duration. In particular, we took into consideration as duration cut-off the 3rd quartile of cumulative breast-feeding duration (corresponding to 20 months) and the 3rd quartile of breast-feeding duration per child (i.e. 13 months).We evaluated breast size with a scale ranging from 1 to 8: 1 ϭ 65 cm; 2 ϭ 70 cm; 3 ϭ 75 cm; 4 ϭ 80 cm; 5 ϭ 85 cm; 6 ϭ 90 cm; 7 ϭ 95 cm and 8 ϭ 100 cm. We considered gynaecological age as Journal of Obstetrics and Gynaecology, January 2012; 32: 58-61 © 2011 Informa UK, Ltd. ISSN 0144-3615 print/ISSN 1364-6893 online DOI: 10.3109/01443615.2011 Benign breast disease (BBD) is very common among women in their fertile age, but its correlation with breast reproductive function remains unclear. Our study ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Breast-feeding and benign breast disease

Bernardi

Londero

Bertozzi³

et al. 2011

Journal of Obstetrics and Gynaecology

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“…26) The present study was conducted in order to evaluate the subsequent breast cancer risk among the BBD patients described in the previous report. Accumulations and comparisons of data among countries with different risk for breast cancer seem necessary for elucidating the association of BBD lesions with breast cancer risk.…”

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confidence: 99%

Risk of Breast Cancer in Japanese Women with Benign Breast Disease

Minami

Ohuchi

Taeda

et al. 1999

Japanese Journal of Cancer Research

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To investigate the risk of breast cancer development in women with benign breast disease (BBD), 387 screen-detected BBD women and 1,489 normal women, taken from participants in the breast cancer screening program during 1978-1986, were followed through 1991. While 2,811 personyears in the BBD group and 11,018 person-years in the normal group were accumulated, 5 women in the BBD group and 6 women in the normal group developed breast cancer. Using the MantelHaenszel method, relative risks (RR) were estimated for all women with BBD and women in some BBD types. Significantly elevated risk of breast cancer was observed in all women with BBD (RR = = = =3.26, 95% confidence interval (CI) 1.08-9.83). Women with proliferative BBD were at high risk of breast cancer (RR = = = =8.48, 95%CI 2.99-24.10), but no increased risk was observed for women with non-proliferative BBD (RR = = = =0.93, 95%CI 0.11-7.66). These results are consistent with those in high-risk countries for breast cancer. In the management of women with BBD, histopathological diagnosis of the breast lesion is essential and women with proliferative BBD should be followed up carefully. Key words:Benign breast disease -Breast cancer risk -Cancer registry -Retrospective cohort study -Screening It has been reported that a history of benign breast disease (BBD) increases breast cancer risk, [1][2][3][4] but recent studies have shown that the risks for subsequent breast cancer in BBD patients who have had a biopsy are different among different histopathological types. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] While the histopathological classification systems used in these studies were not the same, there was a consistent finding that atypical hyperplasia (AH) presents high risk for the development of breast cancer. 20) Although Japan is one of the countries with low risk for breast cancer, the incidence rate of female breast cancer is gradually increasing. 21) A number of epidemiological studies of breast cancer have recently been conducted and the characteristics of Japanese women with breast cancer have been clarified. 3,4,[22][23][24][25] However, there have been few studies on the prognosis in BBD patients 18) and the relation of BBD to breast cancer risk is unclear in Japan.We have reported similarities of background characteristics between proliferative BBD (including AH) and breast cancer, using data obtained from breast cancer screening participants.26) The present study was conducted in order to evaluate the subsequent breast cancer risk among the BBD patients described in the previous report. Accumulations and comparisons of data among countries with different risk for breast cancer seem necessary for elucidating the association of BBD lesions with breast cancer risk. This study provides additional data from a low-risk country for breast cancer. MATERIALS AND METHODSStudy subjects and histopathological classification This study was conducted by using data obtained from breast cancer screening participants during 1978-1986. The breast cancer...

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“…Однако подобные статистические данные являются слишком общими и недостаточно информа-тивными для практического применения [1,2].…”

Section: опухоли женской репродуктивной системы Tumors Of Female Reprunclassified