Risk factors for bile leakage after liver resection for neoplastic disease

Calamia, Sergio; Barbàra, Marco; Cipolla, Calogero; Grassi, Nello; Pantuso, Gianni; Petri, Sergio Li; Pagano, Domenico; Gruttadauria, Salvatore

doi:10.1007/s13304-022-01326-1

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Moreover, during the monitoring, the radiologists’ experience must also concern persistent bleeding, haemobilia, and biliary fistula [ 96 , 97 , 98 , 99 , 100 , 101 ]. Consequently, these complications must be treated to avoid cole-peritoneum and sepsis, which can also worsen the volume injured [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ].…”

Section: Discussionmentioning

confidence: 99%

Future Perspectives on Radiomics in Acute Liver Injury and Liver Trauma

Brunese,

Avella,

Cappuccio

et al. 2024

JPM

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Background: Acute liver injury occurs most frequently due to trauma, but it can also occur because of sepsis or drug-induced injury. This review aims to analyze artificial intelligence (AI)’s ability to detect and quantify liver injured areas in adults and pediatric patients. Methods: A literature analysis was performed on the PubMed Dataset. We selected original articles published from 2018 to 2023 and cohorts with ≥10 adults or pediatric patients. Results: Six studies counting 564 patients were collected, including 170 (30%) children and 394 adults. Four (66%) articles reported AI application after liver trauma, one (17%) after sepsis, and one (17%) due to chemotherapy. In five (83%) studies, Computed Tomography was performed, while in one (17%), FAST-UltraSound was performed. The studies reported a high diagnostic performance; in particular, three studies reported a specificity rate > 80%. Conclusions: Radiomics models seem reliable and applicable to clinical practice in patients affected by acute liver injury. Further studies are required to achieve larger validation cohorts.

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Section: Discussionmentioning

confidence: 99%

Future Perspectives on Radiomics in Acute Liver Injury and Liver Trauma

Brunese,

Avella,

Cappuccio

et al. 2024

JPM

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“…[8][9][10] Risk factors for POBL include anatomic distortion from inflammation or infection, previous surgery, biliary intervention, chemotherapy, malignancy as an indication for surgery, and impaired patient immune or nutritional status. [10][11][12][13][14][15][16] Most bile leaks can be treated either prophylactically or postoperatively with percutaneous drainage, although intraoperative drain placement in uncomplicated surgeries may increase POBL risk. 2,7,11,14,17,18 More severe cases require more extensive drainage, endoscopic procedures, or reoperation for biliary tract reconstruction.…”

Section: Introductionmentioning

confidence: 99%

Assessment of a novel biliary‐specific near‐infrared fluorescent dye (BL‐760) for intraoperative detection of bile ducts and biliary leaks during hepatectomy in a preclinical swine model

et al. 2023

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Objectives: Postoperative bile leakage is a common complication of hepatobiliary surgery and frequently requires procedural intervention. Bile-label 760 (BL-760), a novel near-infrared dye, has emerged as a promising tool for identifying biliary structures and leakage, owing to its rapid excretion and strong bile specificity. This study aimed to assess the intraoperative detection of biliary leakage using intravenously administered BL-760 compared with intravenous (IV) and intraductal (ID) indocyanine green (ICG). Materials and Methods: Laparotomy and segmental hepatectomy with vascular control were performed on two 25-30 kg pigs. ID ICG, IV ICG, and IV BL-760 were administered separately, followed by an examination of the liver parenchyma, cut liver edge, and extrahepatic bile ducts for areas of leakage. The duration of intra-and extrahepatic fluorescence detection was assessed, and the target-to-background (TBR) of the bile ducts to the liver parenchyma was quantitatively measured. Results: In Animal 1, after intraoperative BL-760 injection, three areas of leaking bile were identified within 5 min on the cut liver edge with a TBR of 2.5-3.8 that was not apparent to the naked eye. In contrast, after IV ICG administration, the background parenchymal signal and bleeding obscured the areas of bile leakage. A second dose of BL-760 demonstrated the utility of repeated injections, confirming two of the three previously visualized areas of bile leakage and revealing one previously unseen leak. In Animal 2, neither ID ICG nor IV BL-760 injections showed obvious areas of bile leakage. However, fluorescence signals were observed within the superficial intrahepatic bile ducts after both injections. Conclusions: BL-760 enables the rapid intraoperative visualization of small biliary structures and leaks, with the benefits of fast excretion, repeatable intravenous administration, and high-fluorescence TBR in the liver parenchyma. Potential applications include the identification of bile flow in the portal plate, biliary leak or duct injury, and postoperative monitoring of drain output. A thorough assessment of the intraoperative biliary anatomy could limit the need for postoperative drain placement, a possible contributor to severe complications and postoperative bile leak.

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Raw Data for the article: Risk factors for bile leakage after liver resection for neoplastic disease

Gruttadauria

2023

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Risk factors for bile leakage after liver resection for neoplastic disease

Abstract: Pag CHAPTER 1 Background Pag 2.5 Statistical analysis CHAPTER 3 Results Pag CHAPTER 4 Discussion Pag CHAPTER 5 Tables and Figures Pag Bibliography Pag Scientific Products Pag 46

Cited by 4 publications

References 29 publications

Future Perspectives on Radiomics in Acute Liver Injury and Liver Trauma

Future Perspectives on Radiomics in Acute Liver Injury and Liver Trauma

Assessment of a novel biliary‐specific near‐infrared fluorescent dye (BL‐760) for intraoperative detection of bile ducts and biliary leaks during hepatectomy in a preclinical swine model

Raw Data for the article: Risk factors for bile leakage after liver resection for neoplastic disease

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