Risk factors for bronchiolitis hospitalization in infants: A French nationwide retrospective cohort study over four consecutive seasons (2009-2013)

Abstract

Objectives Large studies are needed to update risk factors of bronchiolitis hospitalization. We performed a nationwide analysis of hospitalization rates for bronchiolitis over four consecutive bronchiolitis seasons to identify underlying medical disorders at risk of bronchiolitis hospitalization and assess their frequency. Methods Data were retrieved from the French National Hospital Discharge database. Of all infants discharged alive from maternity wards from January 2008 to December 2013 in France (N = 3,884,791), we identified four consecutive cohorts at risk of bronchiolitis during the seasons of 2009-2010 to 2012-2013. The main outcome was bronchiolitis hospitalization during a season. Individual risk factors were collected. Results Among infants, 6.0% were preterm and 2.0% had �1 chronic condition including 0.2% bronchopulmonary dysplasia (BPD) and 0.2% hemodynamically significant congenital heart disease (HS-CHD). Bronchiolitis hospitalization rates varied between seasons (min: 1.26% in 2010-2011; max: 1.48% in 2012-2013; p<0.001). Except omphalocele, the following conditions were associated with an increased risk for bronchiolitis hospitalization: solid organ (9.052; 95% CI, 4.664-17.567) and stem cell transplants (6.

Personal and Environmental Risk Factors at Birth and Hospital Admission: Direct and Vitamin D-Mediated Effects on Bronchiolitis Hospitalization in Italian Children

“…Bronchiolitis is one of the most common lower respiratory tract infections in children younger than two years of age [ 1 ]. Lower gestational age (GA) is one of the main host risk factors for bronchiolitis requiring hospitalization during the epidemic seasons [ 2 ]. Even early-term birth (37 + 0–38 + 6 GA) has been associated with an increased risk of admission for bronchiolitis [ 3 ].…”

Bronchiolitis: State-of-the-art

“…The risk factors are male sex, young age between 1-3 months 15 , preterm infants, male sex, being bottle-fed, multiple birth, chronic lung disease of prematurity, hemodynamically significant congenital heart disease (HS-CHD), hemodynamically non-significant CHD, cardiomyopathy, congenital abnormalities of nervous system, trisomy 21, neuromuscular disorders, cystic fibrosis, immunodeficiency, cerebral palsy, bronchopulmonary dysplasia, congenital lung disease and/ or bronchial abnormalities, pulmonary hypertension, solid organ and stem cell transplant. [16][17][18][19][20] Several preventable environmental risk factors for severe bronchiolitis are cigarette smoke, in utero tobacco smoke exposure. 21 Air pollution may also increase the risk for bronchiolitis.…”

Implementation and evaluation of a nurse-driven noninvasive ventilation weaning protocol in infants with severe bronchiolitis

“…Acute bronchiolitis is a severe infection involving young children and a leading cause of hospitalization worldwide 1,2 . Since management of severe bronchiolitis is mainly based on mechanical ventilation, most of patients with bronchiolitis-related acute respiratory failure require admission in a Pediatric Intensive Care Unit (PICU) 3 .…”