Risk Factors for Cancer Chemotherapy-Induced Hiccups (CIH)

Hosoya, Ryuichiro; Tanaka, Ippei; Ishii-Nozawa, Reiko; Amino, Takeshi; Kamata, Tomoyuki; Kagaya, Hajime; Uesawa, Yoshihiro

doi:10.4236/pp.2018.98026

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…Anticancer drugs that have been reported to induce hiccups in the past include fluorouracil [11,35], gemcitabine [13], and cisplatin [8,37]. A mechanism that may be involved in the induction of hiccups by cisplatin is the stimulation of the vagus nerve due to the release of serotonin because of the stimulation of the enterochromaffin cells [38].…”

Section: Discussionmentioning

confidence: 99%

“…Nausea (4.2%) and vomiting (3.4%) have been reported as side effects of immunoglobulin preparations [39]. Immunoglobulininduced hiccups also may be related to nausea and vomiting [13]. There is also the possibility of a new mechanism or a primary disease that is treated with immunoglobulin.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we found a novel risk factor-tall stature-from patient information associated with hiccups [11]. In an exploratory study of risk factors for hiccups in hospitalized patients, we found an association between hiccups and low body mass index (BMI), symptoms of nausea, vomiting, and chemotherapy-related drugs [12,13]. However, the number of reports of hiccups in JADER is relatively small-about 150 cases-and it is limited to reports from within Japan.…”

Section: Introductionmentioning

confidence: 95%

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Analysis of Factors Associated with Hiccups Using the FAERS Database

et al. 2021

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In this study, we used the large number of cases in the FDA adverse-event reporting system (FAERS) database to investigate risk factors for drug-induced hiccups and to explore the relationship between hiccups and gender. From 11,810,863 adverse drug reactions reported between the first quarter of 2004 and the first quarter of 2020, we extracted only those in which side effects occurred between the beginning and end of drug administration. Our sample included 1454 adverse reactions for hiccups, with 1159 involving males and 257 involving females (the gender in 38 reports was unknown). We performed univariate analyses of the presence or absence of hiccups for each drug and performed multivariate analysis by adding patient information. The multivariate analysis showed nicotine products to be key suspect drugs for both men and women. For males, the risk factors for hiccups included older age, lower body weight, nicotine, and 14 other drugs. For females, only nicotine and three other drugs were extracted as independent risk factors. Using FAERS, we were thus able to extract new suspect drugs for drug-induced hiccups. Furthermore, this is the first report of a gender-specific analysis of risk factors for hiccups that provides novel insights into drug-induced hiccups, and it suggests that the mechanism responsible is strongly related to gender. Thus, this study can contribute to elucidating the mechanism underlying this phenomenon.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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Analysis of Factors Associated with Hiccups Using the FAERS Database

et al. 2021

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“…However, there were no sex differences in hiccups caused by central nervous system disorders [ 6 ]. In a study about the risk factors of patient-induced hiccups, low body mass index, nausea and vomiting, and cancer drug therapy were associated with hiccups [ 7 ]. In other reports, cisplatin [ 8 , 9 ] and dexamethasone [ 10 ] have been suspected to affect the development of hiccups.…”

Section: Introductionmentioning

confidence: 99%

“…Drug-induced hiccups may develop hours or days after drug administration and persist for an extended period [ 7 , 10 ]. Therefore, these phenomena are not controlled on a millisecond-by-millisecond basis but rather through the development of several molecular pathways from the time of drug administration.…”

Section: Introductionmentioning

confidence: 99%

The Association between Molecular Initiating Events and Drug-Induced Hiccups

Hosoya,

Ishii-Nozawa,

Terajima

et al. 2024

Pharmaceuticals

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Hiccups can significantly reduce the quality of life of patients and can occur as a drug side effect. Previous reports have revealed sex-specific differences in the incidence of drug-induced hiccups. However, the pathogenesis of drug-induced hiccups remains unknown, and there is limited evidence on its treatment or prevention. This study examined molecular initiating events (MIEs), which are the starting point of adverse events, to investigate the drug-induced pathways of hiccups. We extracted drugs suspected to cause hiccups using the FDA Adverse Event Reporting System, a large database on adverse drug reactions. Information on drugs suspected to be associated with hiccups was extracted from the overall population and sex-specific subgroups were divided. In each data table, the predicted activity values of nuclear receptors and stress response pathways for each drug were calculated using the Toxicity Predictor, a machine-learning model. Transforming growth factor-beta and antioxidant response elements were considered an independent factor for hiccups in the male and female subgroups, respectively. This report first examined one of the mechanisms of drug-induced hiccups and identified MIEs associated with drug-induced hiccups. The use of an adverse event database and the machine-learning model, Toxicity Predictor, may be useful for generating hypotheses for other adverse effects with unknown mechanisms.

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