Risk factors for candidemia mortality in hospitalized children

Abstract

Data from this study suggest that sepsis and septic shock, acute renal insufficiency, and risks like mechanical ventilation and dialysis are associated with increased mortality in pediatric patients. The mortality among patients with candidemia is high, and there is no species difference in mortality rates. Regarding the resistance rates, it is important to emphasize the presence of low resistance in this series.

Candida bloodstream infections in Serbia: First multicentre report of a national prospective observational survey in intensive care units

“…Also, we found that one Candida strain was resistant to FCY (2.3%). As azoles cross‐resistance is emerging nowadays our finding, in which 2 C. albicans strains resistant to ITR (2/10; 20%) were also resistant to other azoles (overall 4.6%) is in accordance to literature and to data from Europe (6.3%) and North America (6.6%) . Our strains were from adult settings and were not associated with mortality but it needs to be taken into consideration when planning azoles prophylaxis or therapy, especially in the Serbian NICU/PICUs.…”

“…A national survey on risk factors associated with fungaemia and ICUs has not been done in Serbia yet, and this first hospital‐based report showed a majority of patients with proven Candida BSI, belonging to LBW neonates, patients with malignancy and abdominal surgeries, similar to data from the literature . A large portion of the Serbian ICU patients were severely ill, had vascular catheters or some medical devices, and were treated with broad spectrum antibacterial drugs.…”

“…C. parapsilosis (~47%) and C. albicans (~36%) prevailed in Spain (2009‐2010, a Fungemyca paediatric study); C. albicans (37%) and C. parapsilosis (31%) in Brazil (2008‐2011); C. albicans (50%) and C. parapsilosis (22%) in Belgium (2013‐2014); C. albicans (50%), C. parapsilosis (25%), C. tropicalis and C. glabrata (6%, each) in the US (2000‐2012); C. krusei (33%) and C. glabrata (28%) in paediatric haematology ICU (Denmark, 2006); C. albicans (46%), C. parapsilosis (17%) and C. glabrata (14%) in German (1998‐2008) …”

Epidemiology, antifungal susceptibility, risk factors and mortality of invasive candidiasis in neonates and children in a tertiary teaching hospital in Southwest China

“…28 The detailed data are shown in Table 5. The annual incidence of neonatal IC was higher than that of non-neonatal IC in our study, which differs from results reported by Tragiannidis et al, 29 Motta et al, 30 Some previous reports showed that C albicans was the main species responsible for invasive Candida infection (C albicans > 50%). 20,25,31,33,34 Nevertheless, recent reports, including our study, have shown that non-albicans Candida species are becoming the dominant species responsible for invasive Candida infection.…”

“…The VRC resistance rate was higher than that reported by Tsai et al 37 and consistent with that in Sutcu et al's 31 report. The FCA resistance rates were lower than those reported by Ota et al 3 and Hsu et al, 28 higher than those reported by Santolaya et al, 19 Tsai et al 37 and Autmizguine et al, 33 and consistent with those reported by Tragiannidis et al, 18 Motta et al, 30 Sutcu et al 31 and Oncu et al 32 The 5-FC resistance rate was lower than that reported by Tragiannidis et al 18 and consistent with those reported by Tsai et al 37 and Sutcu et al 31 Susceptibility to AMB in this study was higher than that reported by Tragiannidis et al 18 and consistent with that reported by Tsai et al, 37 Motta et al, 30 Sutcu et al 31 and Autmizguine et al 33 The detailed data are shown in Table 2 and Table 7.…”