Risk factors for cardiovascular disease in children and young adults with haemophilia

Limjoco, Jacqueline; Thornburg, Courtney D.

doi:10.1111/hae.13585

Cited by 12 publications

(16 citation statements)

References 39 publications

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“…Furthermore, in a Dutch haemophilia cohort, it has been reported that overweight/obesity itself increased the number of joint bleeds and reduced function in the lower limbs (29). Recently, Limjoco and Thornburg (6) reported high rates of overweight and obesity in a relatively younger haemophilia cohort (mean age 12 years, range 5-20 years). However, these authors identified no difference in target joints based on weight category (30% in normal weight vs. 25% in overweight or obese, p=0.74).…”

Section: Discussionmentioning

confidence: 99%

“…Besides atherosclerosis, other established risk factors including obesity, hypertension (HT), dyslipidaemia, diabetes mellitus (DM) and family history for cardiovascular diseases are also known to play a crucial role in mortality and morbidity of these patients (1). Recently, Limjoco and Thornburg (6) studied these risk factors in a young haemophiliac population, aged 5-20 years, and identified modifiable risk factors for cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Alperstein et al (11) reported an increased prevalence of HT in a hospitalized pediatric hemophilia population compared to a pediatric healthy male population, although this was not statistically significant (1.52% vs. 1.22%, p=0.26). Recently, Limjoco and Thornburg (6) reported high rates of overweight and obesity, (pre) HT and abnormal lipid levels in children and young adults with haemophilia.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia

Yildiz¹,

Özdemir²,

Önal³

et al. 2019

Jcrpe

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Objective: Increased risk of unfavorable cardiovascular risk factors has been recognised in ageing patients with haemophilia (PwH), but needs further studies in younger patients. The purpose of this study was to assess obesity, hypertension (HT), metabolic variables, insulin resistance and metabolic syndrome in young PwH. Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included in the study. Anthropometric measurements, blood pressure (BP), fasting glucose and insulin levels, serum lipids and diet were evaluated. The metabolic syndrome was defined according to the criteria of the International Diabetes Federation for pediatric and adult age groups. Results: The mean age of PwH was 21±9 years (range, 6-40 years). Of those ≥18 years, 46% were were obese/overweight while there were no obese/overweight cases in the <18 year-old patients. Obesity was more prevalent in PwH with arthropathy (p=0.017). Seven percent of the PwH between 10 and 18 years-old and 25% of those ≥18 years had metabolic syndrome. There was no difference in metabolic syndrome frequency between PwH and controls >10 years-old (19.5% vs 10% respectively, p=0.34). Fifty percent of the PwH ≥18 years-old had elevated BP or HT. Fasting blood glucose levels of PwH were significantly higher compared to controls (p=0.02). Conclusion: Our study showed that obesity, HT and metabolic syndrome are frequent problems, especially in PwH with arthropathy. Early prevention and management of overweight, obesity and their sequelae must be addressed in clinical practice in order to maximize the overall health of the haemophilia population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia

Yildiz¹,

Özdemir²,

Önal³

et al. 2019

Jcrpe

View full text Add to dashboard Cite

show abstract

“…Alperstein et al reported an increased prevalence of HT in a hospitalized pediatric hemophilia population compared to pediatric male population, although not statistically significant (1.52% vs. 1.22%, p=0.26) (11). Recently, Limjoco et al reported high rates of overweight and obesity, (pre)hypertension and abnormal lipids in children and young adults with haemophilia (6).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…Besides atherosclerosis, which is the first origin of cardiovascular disease beginning in childhood and adolescence, other established risk factors including obesity, hypertension (HT), dyslipidaemia, diabetes mellitus (DM) and family history for cardiovascular diseases are also known to play crucial role in mortality and morbidity of these patients (1). Recently, Limjoco et al studied these risk factors in a young haemophilic population and identified modifiable risk factors for cardiovascular diseases (6).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of unfavorable cardiovascular and metabolic risk factors in children and young adults with haemophilia

Yildiz¹,

Özdemir²,

Önal³

et al. 2018

Jcrpe

View full text Add to dashboard Cite

Objective: Increased risk of unfavorable cardiovascular risk factors has been defined in the aging population of haemophilia however they were less investigated in young patients. The purpose of this study was to assess obesity, hypertension, metabolic variables, insulin resistance and metabolic syndrome in young patients with haemophilia (PwH). Methods: Forty-eight haemophilia A and B patients and 35 age and sex matched healthy controls were included. Anthropometric measurements, blood pressure, fasting glucose and insulin levels, serum lipids and dietary intakes were evaluated. According to the criteria of International Diabetes Federation for pediatric and adult age groups, metabolic syndrome was defined. Results: The mean age of PwH was 21 years (range, 6-40 years). Forty-six percent of the PwH ≥18 years-old were obese/overweight vs none <18 years old. Obesity was more prevalent in PwH with arthropathy (p=0.017). Seven percent of the PwH ≥10 and <18 years-old and 25% of ≥18 years old had metabolic syndrome. There was no difference in metabolic syndrome between PwH and controls >10 years-old (19.5% vs 10% respectively, p=0.34). Fifty percent of the PwH ≥18 years-old had elevated blood pressure or hypertension. Fasting blood glucose levels of PwH were higher compared to controls (p=0.02). Conclusions: Our study showed that obesity, hypertension and metabolic syndrome are frequent problems especially in PwH with arthropathy. Early prevention and management of overweight, obesity, and their sequelae must be addressed in clinical practice in order to maximize the overall health of the haemophilia population.

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Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

Lamoine,

Jury,

Fourneyron

et al. 2024

Research and Practice in Thrombosis and Haemostasis

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Risk factors for cardiovascular disease in children and young adults with haemophilia

Abstract: Modifiable risk factors for CVD were identified as part of the study during comprehensive clinic visits. The HTC team may develop behavioural interventions to target cardiovascular risk reduction as part of the comprehensive care model.

Cited by 12 publications

References 39 publications

Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia

Evaluation of Unfavorable Cardiovascular and Metabolic Risk Factors in Children and Young Adults with Haemophilia

Evaluation of unfavorable cardiovascular and metabolic risk factors in children and young adults with haemophilia

Thrombin generation to evaluate the complex hemostatic balance of hemophilia A plasma containing direct oral anticoagulant and supplemented by factor VIII

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