Risk factors for cardiovascular disease in ethnic Europeans and Koreans living in the Primorsky Krai

Aim. To determine the association of single nucleotide polymorphism (SNP) -1562C>T (rs3918242) in the matrix metalloproteinase 9 (MMP-9) gene in hypertensive (HTN) in individuals of European and South Asian ethnicity of Primorsky Krai and Sakhalin Oblast.Material and methods. The analysis of conventional and additional risk factors for cardiovascular diseases (35 parameters) in 377 people as a part of regional stage of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study (2014-2019), of whom 240 people of European (Slavic) and 137 people of South Asian (Korean, second- and third-generation immigrants) ethnicity. Substitutions in the MMP-9 gene -1562C>T (rs3918242) was identified by real-time polymerase chain reaction using TaqMan technology.Results. Compared to Koreans, the Slavs have a higher blood pressure (p=0,002). There were no significant differences between ethnic groups (p=0,07) in cardiovascular risk levels using the Systematic Coronary Risk Evaluation (SCORE). Significant differences (p=0,003) were determined in cardiovascular risk levels for healthy Koreans and HTN patients. It was shown that among patients with HTN, the pulse wave velocity exceeded the recommended values in 22,2% of Europeans and in 46,6% of Koreans (p=0,003). The number of hypertensive Europeans and minor MMP-9 rs3918242 T allele exceeded 2,6 times the number of healthy persons (odds ratio, 4,7; 95% confidence interval: 1,1 -7,8 (p=0,03)). MMP-9 rs3918242 T allele in Koreans of the Sakhalin Oblast was not associated with HTN (odds ratio, 0,81; 95% confidence interval: 0,12-5,54 (p=0,83)). Moreover, in South Asian population, heterozygous carriers of T allele prevailed, which significantly (p=0,002) differed from Europeans, who, in general, had a homozygous CC genotype.Conclusion. In Far Eastern Federal District, SNPs in the MMP-9 C-1562T gene were found mainly in hypertensive patients of European ethnicity, while in Koreans, a significant relationship between the carriage of minor T allele in this gene and the presence of HTN was not established.

show abstract

Single nucleotide substitutions in the matrix metalloproteinase 9 gene in hypertensive individuals of European and South Asian ethnicity in the Far Eastern Federal District

Плехова

Brodskaya

Невзорова

et al. 2022

Cardiovasc Ther Prev

Self Cite

View full text Add to dashboard Cite

show abstract

Comparative assessment of cardiovascular risk in European and Korean ethnic groups in the Russian population using the SCORE and SCORE2

Bogdanov

Невзорова

Shestopalov³

2022

Cardiovasc Ther Prev

Self Cite

View full text Add to dashboard Cite

Aim. To carry out a comparative assessment of cardiovascular risk (CVR) in people aged 40-49 years of European and Korean ethnicity with a single residence area using the Systematic Coronary Risk Evaluation (SCORE) and SCORE2 scales.Material and methods. We examined 397 and 50 apparently healthy individuals of the European (EEG) and Korean (KEG) ethnic groups, respectively, who were evaluated for CVR according to the SCORE and SCORE2 charts.Results. According to the SCORE system, the median CVR in the EEG was 0 [0-0] vs 0 [0-1]% in the KEG (p<0,001), while from a clinical point of view, the groups did not differ from each other. The SCORE2 system demonstrated more significant clinical results as follows: the median risk in EEG individuals was 5 [3-8]%, which corresponds to a high CVR for this age group, and 8 [4-11]% in KEG individuals, which corresponds to a very high CVR (p=0,011). CVR assessment in apparently healthy individuals is decisive in considering the preventive measures. According to the SCORE system, 97,5% and 96% of apparently healthy EEG and KEG individuals, respectively, are classified as low and moderate risk. High and very high risk when using this system was determined in 2,5 and 4% among Europeans and Koreans, respectively. However, using the SCORE2 system, only 10,3% of Europeans were classified as low/ moderate risk, and among ethnic Koreans — 8%. At the same time, the category of high and very high risk was designated, respectively, for 63,7 and 25,9% in the EEG and 40 and 52% in the KEG, respectively. It has been established that according to the SCORE2 system, more than half of Koreans aged 40-49 already have a very high CVR, which significantly distinguishes this group from the European population.Conclusion. The SCORE2 system has a more differentiated approach in determining individual CVR. The SCORE2 assessment of non-high density lipoprotein cholesterol levels makes it more personalized for use in different ethnic populations.

show abstract

Comparative characteristics of lifestyle, office and ambulatory blood pressure among students from Tropical Africa, India and Russia

Mangileva

2023

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim. To study the dependence of office and ambulatory blood pressure (BP) level in students with their ethnicity.Material and methods. A total of 110 students were examined as follows: 35 from Russia, 34 from Tropical Africa and 41 from India. Lifestyle was studied using a standardized questionnaire. All students underwent measurement of office blood pressure and 24-hour ambulatory blood pressure monitoring (ABPM) using the BPLabH system (Russia).Results. Students from Russia were more likely to lead a sedentary lifestyle than from Africa (p=0,001) or India (p=0,027). Students from Tropical Africa added salt to food more often than Indians (p=0,03). Office blood pressure measured in the first half of the day was within the normal range for all subjects and did not differ between different ethnic groups. According to ABPM, there were no intergroup differences in systolic blood pressure during the daytime and 24 hours. Diastolic blood pressure of Africans during the daytime (p=0,029) and 24 hours (p=0,002) was higher than in Russians. Nighttime systolic and diastolic blood pressure of African students was significantly higher than in Russian (p=0,006 and p<0,0001, respectively) or Indians (p=0,008 and p=0,006, respectively). Africans showed a smaller blood pressure decrease at night and were more likely to have masked hypertension at night than Russians (p=0,004) or Indians (p=0,046).Conclusion. Office BP did not vary by ethnicity. With ABPM, no differences in blood pressure levels were found between Indian and Russian students. African students had higher blood pressure at night, including masked hypertension, than students from India or Russia.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Risk factors for cardiovascular disease in ethnic Europeans and Koreans living in the Primorsky Krai

Cited by 4 publications

References 17 publications

Single nucleotide substitutions in the matrix metalloproteinase 9 gene in hypertensive individuals of European and South Asian ethnicity in the Far Eastern Federal District

Single nucleotide substitutions in the matrix metalloproteinase 9 gene in hypertensive individuals of European and South Asian ethnicity in the Far Eastern Federal District

Comparative assessment of cardiovascular risk in European and Korean ethnic groups in the Russian population using the SCORE and SCORE2

Comparative characteristics of lifestyle, office and ambulatory blood pressure among students from Tropical Africa, India and Russia

Contact Info

Product

Resources

About