Risk factors for cardiovascular malformation - a study based on prospectively collected data

Cedergren, Marie; Selbing, Anders; Källén, Bëngt

doi:10.5271/sjweh.641

Cited by 61 publications

(77 citation statements)

References 23 publications

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“…En resumen, lo que se conoce actualmente sobre el tema, es que el promedio de edad paterna ha ido aumentando progresivamente en otros países y en Chile y que la implicancia de este hecho sobre la salud pública no ha sido profundamente estudiada ni debatida, principalmente por la limitada evidencia epidemiológica 27 . La acumulación de mutaciones durante la maduración de las células espermáticas en el hombre podrían ser las responsables del creciente riesgo de ciertas enfermedades relacionadas con la edad paterna avanzada.…”

Section: Discussionunclassified

La edad paterna como factor de riesgo para malformaciones congénitas

Z³

et al. 2008

Rev. méd. Chile

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Section: Discussionunclassified

La edad paterna como factor de riesgo para malformaciones congénitas

Z³

et al. 2008

Rev. méd. Chile

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“…Figure 4 shows the dose-response relation between maternal smoking during pregnancy and birth defects in children. Sixty studies 6,7,8,9,11,12,16,21,24,32,43,44,47,48,49,51,57,58,64,65,69,74,80,82,85,88,89,90,91,92,99,100,101,103,104,107,108,113,115,119,121,122,123,124,132,135,144,150,151,157,163,…”

Section: Resultsmentioning

confidence: 99%

“…Compared to that review, this one has included 20 additional studies 6,7,8,9,10,11,12,13,14,24,43,79,83,95,99,102,103,122,125,188 that have added about 10,000 cases of defects, and 800,000 of controls. Another difference between the two reviews is that 19 studies about abdominal wall defects were included in the meta-analysis of the gastro-intestinal system in the previous review, whereas these defects were classified as pertaining to the musculoskeletal system in this review.…”

Section: Discussionmentioning

confidence: 99%

“…While this investigation was being carried out, a systematic review with 101 observational studies was published, and showed an association between maternal smoking during pregnancy and different birth defects in children 5 . This review, however, did not include a considerable number of relevant studies 6,7,8,9,10,11,12,13,14 . Moreover, defects of the abdominal wall, such as congenital diaphragmatic and inguinal hernia, gastroschisis, and omphalocele, which should be considered musculoskeletal abnormalities, according to the 10 th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) 15 were classified as gastrointestinal defects.…”

Section: Introductionmentioning

confidence: 99%

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Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis

et al. 2014

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“…[1][2][3][4][5][6][7][8][9] It is not clear whether the association between obesity and CHD can be explained by maternal diabetes, a known teratogen, because previous studies have not had detailed information on maternal glucose status. It is also not known whether mild elevations in maternal glucose could be responsible for the excess in CHD seen in offspring of obese women.…”

Section: Background and Significancementioning

confidence: 99%

Erratum: Maternal overweight and obesity and risk of congenital heart defects in offspring

Brite¹,

Laughon²,

Troendle³

et al. 2014

Int J Obes

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Objective-Obesity is a risk factor for congenital heart defects (CHD), but whether risk is independent of abnormal glucose metabolism is unknown. Data on whether overweight status increases risk is also conflicting.Research Design and Methods-We included 121815 deliveries from a cohort study, the Consortium on Safe Labor, after excluding women with pregestational diabetes as recorded in the electronic medical record. CHD were identified via medical record discharge summaries. Adjusted odds ratios (OR) for any CHD were calculated for prepregnancy body mass index (BMI) categories of overweight (25 to <30 kg/m 2 ), obese (30 to <40 kg/m 2 ), and morbidly obese (≥40 kg/m 2 ) compared to normal weight (18.5 to <25 kg/m2) women, and for specific CHD with obese groups combined (≥30 kg/m 2 ). A sub-analysis adjusting for oral glucose tolerance test (OGTT) results where available was performed as a proxy for potential abnormal glucose metabolism present at the time of organogenesis.Results-There were 1388 (1%) infants with CHD. Overweight (OR=1.15 95% CI: 1.01-1.32), obese (OR=1.26 95% CI: 1.09, 1.44), and morbidly obese (OR=1.34 95% CI: 1.02-1.76) women had greater odds of having a neonate with CHD than normal weight women (P< 0.001 for trend). Obese women (BMI ≥30 kg/m 2 ) had higher odds of having an infant with conotruncal defects (OR=1.34 95%CI: 1.04-1.72), atrial septal defects (OR =1.22 95% CI: 1.04-1.43), and ventricular Users may view, print, copy, download and text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms Dr. S. Katherine Laughon, Epidemiology Branch, NICHD, National Institutes of Health, 6100 Executive Blvd., Room 7B03, Rockville, MD 20852, Tel: 301-435-6935, laughonsk@mail.nih.gov. Supplementary information is available at the journal's website. Duality of interestThe authors report no conflicts of interest. Conclusion-Increasing maternal weight class was associated with increased risk for CHD. In obese women, abnormal glucose metabolism did not completely explain the increased risk for CHD; the possibility that other obesity-related factors are teratogenic requires further investigation. HHS Public Access

show abstract

Risk factors for cardiovascular malformation - a study based on prospectively collected data

Cited by 61 publications

References 23 publications

La edad paterna como factor de riesgo para malformaciones congénitas

La edad paterna como factor de riesgo para malformaciones congénitas

Maternal smoking during pregnancy and birth defects in children: a systematic review with meta-analysis

Erratum: Maternal overweight and obesity and risk of congenital heart defects in offspring

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