Risk factors for cartilage damage and osteoarthritis of the elbow joint: case-control study and systematic literature review

Spahn, Günter; Lipfert, J.-U.; Maurer, Constance; Hartmann, Bernd; Schiele, R.; Klemm, H.‐T.; Grifka, Joachim; Hofmann, Gunther O.

doi:10.1007/s00402-017-2654-6

Cited by 17 publications

(10 citation statements)

References 29 publications

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“…Other specific directions may be to consider OA, entheses, and CSG in younger individuals. While the first two conditions are strongly associated with age, both osteological and clinical research show that biomechanical patterns (e.g., athletics, injury) of skeletal changes may be influenced by young people's diet, movement, and activity intensity (Becker and Goldstein, 2017;Chen et al, 2017;DiVasta et al, 2007;Karakostis et al, 2018;Macintosh et al, 2017;Miller et al, 2018;Nicholson et al, 2009;Schrader, 2019;Spahn et al, 2017;Wallace et al, 2017). Three-dimensional scans of long bones could also be included as a future research method, from both skeletal collections and CT or MRI scans from various ages of living people with varying levels of physical activity, to create a global database of individual bone changes.…”

Section: Discussionmentioning

confidence: 99%

Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions

Becker

2020

International Journal of Paleopathology

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Akin to approaches encouraged by Verano (1997) in the Andes, and Ortner (2011, 2012) for general paleopathological studies, this article focuses on accurate descriptions and definitions of osteoarthritis, entheses, and long bone cross-sectional geometry. By evaluating these conditions as part of biological responses to abnormal skeletal changes and biomechanical stress, this research discusses each condition's pathogenesis. Further, this article emphasizes a "small data" approach to evaluating these conditions in ancient culturally and biologically related human populations, where the study samples must have good skeletal preservation, where estimates of age and sex need to be included as major factors, and where abnormalities need to be described and evaluated. This article also discusses global clinical and osteological research on ways scholars are currently trying to establish industry-wide methods to evaluate osteoarthritis, entheses, and long bone cross-sectional geometry. Recent studies have focused on rigorous evaluation of methodological techniques, recording protocols, and interand intra-observer error problems. Additionally, scholars have focused on physical intensity of movement using biomechanics, evaluated burials of known occupation, and used complex statistical methods to help interpret skeletal changes associated with these conditions. This article also narrows to focus on these conditions within thematic "small data" areas throughout the Andes. This research concludes with describing future directions to understand skeletal changes, such as more multidisciplinary studies between osteologists and pathologists, collaborations with living people to collect CT, x-rays, or computer-aided motion capture, and a stronger focus on how these conditions correlate with intense biomechanical changes in younger individuals. Andean lifeways in terms of power, labor, economic activities, and identity. Early research correlated OA, entheses, and CSG as indicators of past activities, or used them to reconstruct movements associated with things like canoe paddling or spear throwing (e.g., Hawkey and Merbs, 1995; Kennedy, 1989; Merbs, 1983). Jurmain et al. (1999; 2012) have critiqued these approaches as "activity-only myopia," or a "Holy Grail" quest, identifying problems and concerns in description and interpretation with these methods. This has led to a reassessment of OA, entheses, and CSG, and an interrogation of if activity reconstruction in archaeological samples is even possible. Recent research on OA, entheses, and CSG has reevaluated methodological techniques, statistical assessments, recording protocols, inter-and intra-observer error problems, movement and biomechanics, and pathological changes on burials of known occupation, with no one solution (

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Section: Discussionmentioning

confidence: 99%

Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions

Becker

2020

International Journal of Paleopathology

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“…Obwohl die Wiederherstellung der Anatomie nicht immer zielführend ist, sind mögliche Fehlstellungen, eine chronische Instabilität und dieinsbesondere posttraumatische -Ankylose vor Beginn einer knorpelregenerativen Therapie auszuschließen oder zu adressieren [93].…”

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Operative Knorpeltherapie aktuell

Hinz¹,

Imhoff²,

Schmitt³

2021

Z Orthop Unfall

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ZusammenfassungFokale Knorpelschäden gehen mit Schwellung, Funktionsverlust der betroffenen Gelenke und starker Schmerzsymptomatik einher. Zudem werden sie mit der Entstehung einer späteren Arthrose in Verbindung gebracht. Oftmals betroffen sind hierbei junge, sportlich aktive Patienten, die einen hohen funktionellen Anspruch haben. Die Behandlungsmöglichkeiten des Orthopäden in Bezug auf knorpelregenerative Therapiemöglichkeiten an Knie, Hüfte, Schulter, Ellenbogen und Sprunggelenk sind mannigfaltig.

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“…Mesenchymal stem cells are multipotent cells able to differentiate into any type of cell of mesodermal lineage in vitro; these include chondrocytes, osteocytes and adipocytes [16]. However, in vivo, this has not yet been demonstrated [17- 19].Tenocytes also have some limited potential as a progenitor cell [20].These unique abilities render cell-based preparations a potentially invaluable tool in the treatment of musculoskeletal sports injuries, and may offer a quicker return to sport [21][22][23]. In vivo, the therapeutic effect of MSC are likely resulting from their trophic, paracrine and immunomodulatory functions as opposed to proliferation and differentiation [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Cell-based therapies for the treatment of sports injuries of the upper limb

Baryeh

Asopa

Kader

et al. 2021

Expert Opinion on Biological Therapy

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Introduction:The use of cell-based therapies in the management of sports injuries of the upper limb is increasingly popular despite the limited scientific evidence available for their use. We aim to evaluate the evidence for the use of cell-based therapies in these injuries and recommend areas for further research.Areas Covered: In accordance with a published protocol (PROSPERO; Registration No. CRD42020193258), a comprehensive search of the literature was performed using the MEDLINE and EMBASE databases from inception to June 2020. All human studies reporting on the clinical, histological or radiological outcomes following the use of cellbased therapies in the management of epicondylitis or rotator cuff pathology were included in this study. This resulted in 22 studies being included in this review, all of which underwent risk of bias assessments. Expert opinion:The evidence for the use of cell-based therapies in upper limb sports injuries is limited and generally of low quality. Given the heterogeneity in the cell types used, their harvesting methods and cell amounts, future research should be targeted at developing standardisation of the reporting of these studies and more direct comparative studies looking at the efficacy of the different cell types.

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Risk factors for cartilage damage and osteoarthritis of the elbow joint: case-control study and systematic literature review

Cited by 17 publications

References 29 publications

Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions

Osteoarthritis, entheses, and long bone cross-sectional geometry in the Andes: Usage, history, and future directions

Operative Knorpeltherapie aktuell

Cell-based therapies for the treatment of sports injuries of the upper limb

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