1996
DOI: 10.3109/02841869609084002
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Risk Factors for Central Nervous System Involvement in Non-Hodgkins-Lymphoma a multivariate analysis

Abstract: A consecutive cohort of patients with NHL was examined to identify the factors predictive of CNS-involvement with Cox's proportional hazards model in a multivariate analysis. Twenty-seven cases of CNS-involvement were found among 498 patients with NHL. Only 3 of 96 patients with low-grade lymphomas had CNS involvement, all occurring after transformation into high-grade lymphoma. In univariate analysis of 402 patients with intermediate or high-grade lymphoma, lymphoblastic histology (including Burkitt's lymphom… Show more

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Cited by 62 publications
(40 citation statements)
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“…7 In HIV-negative patients with high-grade NHL, bone marrow involvement correlates with lymphomatous involvement of the central nervous system. [34][35][36][37] The current report clearly establishes a Figure 1. Survival in AIDS-NHL patients with and without bone marrow involvement.…”
Section: Discussionmentioning
confidence: 98%
“…7 In HIV-negative patients with high-grade NHL, bone marrow involvement correlates with lymphomatous involvement of the central nervous system. [34][35][36][37] The current report clearly establishes a Figure 1. Survival in AIDS-NHL patients with and without bone marrow involvement.…”
Section: Discussionmentioning
confidence: 98%
“…1,2,4,5,[19][20][21][22]25 The role of upfront autologous stem cell transplant following first remission in transformed lymphomas has not been well established and there is no data assessing its role in discordant cases. 51,52 An increased risk of central nervous system (CNS) involvement and CNS relapse in newly diagnosed patients with DLBCL who have concordant BMI has been well described, [53][54][55] and therefore cerebrospinal fluid sampling for lymphomatous involvement and prophylactic CNS-directed therapy are common practice. 56,57 In contrast, discordant indolent BMI in patients with nodal DLBCL has not been associated with an increased risk of CNS involvement/relapse and should not mandate cerebrospinal fluid sampling in the absence of other high-risk characteristics.…”
Section: Therapeutic Approach To Discordant Lymphomasmentioning
confidence: 99%
“…Involvement of the central nervous system (CNS) is considered to be rare in nontransformed small cell lymphomas [4,16]. In MCL the incidence of CNS involvement has not been studied in detail.…”
Section: Introductionmentioning
confidence: 99%