Risk factors for cerebral palsy in neonates due to placental abruption

Abstract

Aim: This study aimed to identify risk factors for the onset of cerebral palsy (CP) in neonates due to placental abruption and investigate their characteristics. Methods: A retrospective case-control study was conducted using a nationwide registry from Japan. The study population included pregnant women (n = 122) who delivered an infant with CP between 2009 and 2015, where placental abruption was identified as the single cause of CP. The control group consisted of pregnant women with placental abruption, who delivered an infant without CP and were managed from 2013 to 2014. They were randomly identified from the prenatal database of the Japan Society of Obstetrics and Gynecology (JSOG-DB; n = 1214). Risk factors were investigated using multivariate analysis. Results: Alcohol consumption (3.38, 2.01-5.68) (odds ratio, 95% confidence interval), smoking during pregnancy (3.50, 1.32-9.25), number of deliveries (1.28, 1.05-1.56), polyhydramnios (5.60, 1.37-22.6), oral administration of ritodrine hydrochloride (2.09, 1.22-3.57) and hypertensive disorders in pregnancy (2.25, 1.27-4.07) were significant risk factors. In contrast, intravenous administration of oxytocin (odds ratio, 95% confidence interval: 0.22, 0.09-0.58) and magnesium sulfate (0.122, 0.02-0.89) attenuated risk. Conclusion: Alcohol consumption, smoking during pregnancy, number of deliveries, polyhydramnios, oral administration of ritodrine hydrochloride and hypertensive disorders in pregnancy were identified as risk factors for CP following placental abruption. Regarding alcohol consumption and smoking during

Habitual Smoking and Perinatal Outcomes in Japan

“…The present study found that maternal habitual smoking in pregnancy was associated with adverse perinatal outcomes such as the increased incidence of placental abruption and light-for-gestational-age neonate as previously reported [1][2][3][4]6]. The characteristic abnormalities caused by smoking have been reported to provide additional insights into the genes and processes important for the formation of the fetal-maternal interface associated with the adverse perinatal consequences [3].…”

“…In 2021, smoking during pregnancy was reported to be identified as one of the main risk factors for cerebral palsy following placental abruption in Japan [4]. Among the pregnant women who developed placental abruption registered in the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC), the rate of smoking during pregnancy was reported to be 9.7% [5].…”

“…Among the pregnant women who developed placental abruption registered in the Japan Obstetric Compensation System for Cerebral Palsy (JOCSC), the rate of smoking during pregnancy was reported to be 9.7% [5]. However, there have been few investigations of widespread examinations of habitual smoking during pregnancy and perinatal outcomes in Japanese women [4,6]. Therefore, we investigated the perinatal outcomes in women diagnosed with habitual smoking during pregnancy and were managed at our institute, which is one of the main perinatal centers in Tokyo, Japan.…”

Analysis of Selected Risk Factors Depending on the Type of Cerebral Palsy

“…A number of various factors may cause damage to the central nervous system at an early stage of its development. Potential risk factors for CP can be divided into: pre-conception (concerning the broadly defined health and living conditions of the mother) and prenatal (related to the course of pregnancy), perinatal, neonatal, and infant period-related risk factors [ 4 , 5 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. …”

“…perinatal, neonatal, and infant period-related risk factors [ 4 , 5 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”