Risk Factors for Cervical Intraepithelial Neoplasia in Taiwan

Wang, Pair Dong; Lin, Ruey S.

doi:10.1006/gyno.1996.0183

Cited by 33 publications

(19 citation statements)

References 17 publications

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“…In Taiwan, 1.0% of screened women were diagnosed with CIN. 29 Reports from Victoria, Australia, indicated an overall prevalence of CIN of 3.6%, whereas for aboriginal Australian women, the rate was 1.6%. 30 Analysis of Canadian data indicated patterns similar to those in our program, with younger women having the highest proportion of abnormal smears and biopsy-detected lesions.…”

Section: Discussionmentioning

confidence: 91%

Cervical Screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001

Benard¹,

Eheman²,

Lawson³

et al. 2004

Obstetrics & Gynecology

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Section: Discussionmentioning

confidence: 91%

Cervical Screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001

Benard¹,

Eheman²,

Lawson³

et al. 2004

Obstetrics & Gynecology

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“…The high prevalence of HPV-6 and -18 among the controls, even though only 2.7 % of the women reported having had more than one lifetime sexual partner, may have been due to the sexual behaviour of the husbands. A previous population-based case-control study from Taiwan reported that 71.9 and 58.3 % of husbands of women with cervical intraepithelial neoplasia and healthy controls, respectively, had visited a prostitute during the last year (Wang & Lin, 1996b). Another plausible explanation is the presence of alternative transmission routes in this population.…”

mentioning

confidence: 77%

Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case–control study

Nauclér

Chen

Persson

et al. 2007

Journal of General Virology

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A nested case-control study of invasive and in situ cervical cancer was performed within a community-based cohort of 13 595 Taiwanese women assembled in 1991, with a follow-up period of 9 years. Baseline serum or plasma samples were analysed for antibodies against human papillomavirus (HPV) types 6, 16 and 18 and Chlamydia trachomatis. In total, 114 cases (42 incident cases identified during follow-up and 72 prevalent cases identified at baseline) and 519 matched controls were included in the study. HPV-16 seropositivity was strongly associated with cervical cancer (OR56.33; 95 % CI 3. 45-11.62). Overall, C. trachomatis was not associated with cervical cancer, but was associated with cervical cancer in analyses restricted to incident cases of cancer (OR52.94; 95 % CI 1.17-7.42) or to cases in which serum samples were analysed (OR53.13; 95 % CI 1. 16-8.47). An antagonistic interaction between HPV-6 and -16 was found in a multiplicative model. These results suggest that different HPV types might interfere in cervical carcinogenesis and that C. trachomatis is associated with cervical cancer in prospective studies, and support the notion that HPV-16 seropositivity is strongly associated with cervical cancer. INTRODUCTIONCervical cancer is the most common cancer among women in Taiwan, with an age-standardized incidence rate of 22.1 per 100 000 person-years compared with a mean of 11.2 in developed countries (Parkin et al., 1993;Wang & Lin, 1996a). It is well established that the major cause of cervical cancer is persistent infection with oncogenic genital human papillomavirus (HPV) (Walboomers et al., 1999) and that both cervical cancer and HPV infection are associated with high-risk sexual behaviour Silins et al., 2002). The HPV type distribution varies among geographical regions but, worldwide, HPV-16 is the most common HPV type in cervical cancer (Clifford et al., 2003; Nauclér et al., 2004).As the majority of HPV infections are transient (Evander et al., 1995; Hildesheim et al., 1994;Ho et al., 1998), viral genome detection is an imperfect marker of past HPV infection (Olsen et al., 1997). However, HPV antibody levels have been shown to be stable over time, even after more than a decade of follow-up (af Geijersstam et al., 1998;Shah et al., 1997), and correlate with life-time cumulative HPV exposure (Shah et al., 1997;Wang et al., 1997). Prospective seroepidemiological studies have found that the presence of IgG antibodies against HPV-16 is associated with an increased risk of cervical cancer (Shah et al., 1997;Wang et al., 1997), in particular in low-sexualrisk-taking populations Lehtinen et al., 1996).In spite of the fact that exposure to oncogenic HPV increases with the number of sexual partners, there is no excess risk of developing cervical cancer in patients with a history of condylomata acuminata, which is caused by sexually transmissible infections with the benign HPV types 6 and 11 (Sigurgeirsson et al., 1991). A possible explanation is that benign HPV types might interfere with the oncogenicity of high...

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“…For example, a man visiting a sex worker in Taiwan is tolerated within the society, whereas female virginity before marriage and fidelity after marriage are highly valued. Wang and Lin (1996) reported that 58% of men in Taiwan reported having visited sex workers; and less than 20% ever used a condom during sexual intercourse with sex workers. Additionally, in Taiwanese tradition women are expected to be submissive to their father at home, their husband after marriage, and their sons after the death of their husband (Yeh, 2002).…”

Section: Discussionmentioning

confidence: 98%

Knowledge, Attitudes, and Behaviors Related to HIV and AIDS Among College Students in Taiwan

Tung

Ding²,

Farmer³

2008

Journal of the Association of Nurses in AIDS Care

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HIV infection rates in Taiwan have been growing at nearly 15% per year since 1997, one of the fastest rates in Asia. Little is known about the knowledge, attitudes, and sexual behaviors of college-age young adults in Taiwan. This study assessed the knowledge, attitudes, sources of HIV information, and behaviors related to HIV among college students; it also explored variables associated with the knowledge and attitudes about HIV among college students in Taiwan. Data were collected through a self-administered questionnaire from 132 Taiwanese college students enrolled in two private universities. Study results showed that fewer than half (48.5%) of the participants were aware that HIV could be spread through infected semen, and, nearly a quarter of participants believed that HIV could be contracted through mosquito bites, toilet seats, or swimming pools. Only 29.5% reported ever having had sex. This research provides additional insights that may be used to develop effective HIV prevention strategies in Taiwan.

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Risk Factors for Cervical Intraepithelial Neoplasia in Taiwan

Cited by 33 publications

References 17 publications

Cervical Screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001

Cervical Screening in the National Breast and Cervical Cancer Early Detection Program, 1995–2001

Seroprevalence of human papillomaviruses and Chlamydia trachomatis and cervical cancer risk: nested case–control study

Knowledge, Attitudes, and Behaviors Related to HIV and AIDS Among College Students in Taiwan

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