Risk factors for chronic kidney disease: an update

Kazancıoğlu, Rümeyza

doi:10.1038/kisup.2013.79

Cited by 525 publications

(433 citation statements)

References 28 publications

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“…We did not record the ethnic background or birth weight. In addition to the associations through multivariate analysis, univariate analysis found significant differences between the normal and dysfunctional renal function groups in terms of smoking history, drinking history, history of malignancy, family history of CKD, triglyceride, and APO-B so these results are similar to previous findings [30]. …”

Section: Discussionsupporting

confidence: 84%

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A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

Xue

Zhang

Teng

et al. 2016

Nephron

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Background/Aims: Proteinuria and hematuria detected by routine urinalysis can indicate impaired renal function. This study evaluated the effect of routine urinalysis in screening out patients with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m² at an early stage and investigated its associated factors. Methods: Healthy adults who underwent physical examination between September 2008 and September 2013 were enrolled in the study (n = 43,516). Urine was analyzed for protein, and red and white blood cells. Ten milliliter blood samples were collected for serum creatinine, urea, albumin and other parameters for the estimation of eGFR and renal function. Results: Abnormal routine urinalysis was found in 7.1% and eGFR <60 ml/min/1.73 m² was found in 0.9% of subjects. Age and gender were similar in the overall and abnormal urinalysis populations (43 vs. 43 years and 36.7 vs. 38.2% females, respectively), but the eGFR <60 ml/min/1.73 m² group were older (64 years, p < 0.001) with increased females (46.4%, p = 0.002). Sensitivity for predicting eGFR <60 ml/min/1.73 m² was 0.110 and specificity was 0.928. Univariate and multivariate analyses in 6,318 subjects with more detailed clinical data suggested significant associations of sex (OR 0.058, 95% CI 0.030-0.113), age (OR 1.045, 95% CI 1.027-1.064), and high density lipoprotein (HDL) (OR 0.158, 95% CI 0.043-0.587) with eGFR <60 ml/min/1.73 m². Conclusion: Routine urinalysis showed a poor performance in the screening for early-stage renal insufficiency. In future, other screening methods should be considered. Age, gender and HDL were associated with eGFR <60 ml/min/1.73 m².

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Section: Discussionsupporting

confidence: 84%

“…There is a strong relationship with race, older age, gender, low birth weight and a family history of kidney disease, and an association with smoking, obesity, hypertension, and diabetes mellitus [30]. The associated factors for eGFR <60 ml/min/1.73 m 2 identified in this study by multivariate analysis were age, gender and HDL.…”

Section: Discussionmentioning

confidence: 69%

A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

Xue

Zhang

Teng

et al. 2016

Nephron

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“…In the past decades, the prevalence of CKDs is increasing with the rapid growth of hypertension, diabetes and other metabolic disorders [1]. Among the insults resulting in the CKD progression, proteinuria is proven as an independent risk factor [2].…”

Section: Introductionmentioning

confidence: 99%

Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury

Zhuang¹,

Zhao²,

Liang³

et al. 2017

Cell Physiol Biochem

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Background/Aims: The activation of NOD-like receptor family, pyrin domain containing3 (NLRP3) inflammasome has been shown to be positively correlated with the severity of proteinuria in chronic kidney disease (CKD) patients. Prostaglandin E2 (PGE2), an important inflammatory mediator, is also involved in various kidney injuries. The aim of the present study was to investigate the involvement of NLRP3 inflammasome and PGE2 synthetic pathway in albumin-induced renal tubular injury. Methods: Murine proximal tubular cells (mPTCs) were treated with albumin to induce cell injury. NLRP3 siRNA and specific COX-2 inhibitor NS398 were used to define their roles in mediating albumin-induced mPTC injury or the activation of COX-2/mPGES-1/PGE2 cascade. Results: In mPCTs, inhibition of NLRP3 by a small interfering RNA (siRNA) blocked albumin-induced kidney injury molecule 1 (KIM-1) upregulation, inflammatory response, and cell apoptosis. Albumin markedly activated cyclooxygenase-2 (COX-2)/ microsomal prostaglandin E synthase-1 (mPGES-1)/PGE2 pathway in this cell line, an effect largely abolished by NLRP3 silencing at both mRNA and protein levels. More interestingly, blockade of COX-2 using a specific COX-2 inhibitor NS398 markedly inhibited the upregulation of KIM-1 and inflammatory cytokines, and attenuated cell apoptosis in line with blunted PGE2 release following albumin treatment. Conclusions: The findings suggest that COX-2/mPGES-1/PGE2 axis could be activated by albumin in the proximal tubular cells via a NLRP3 inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.

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“…1,2 In China, the largest developing country worldwide, the overall prevalence of CKD accounted for approximately 10.8%, which affected an estimated 119.5 million adults in China. 3 The incidence of ESRD was high and increasing rapidly, and mainland China has to face the huge burden of renal replacement therapy (RRT).…”

Section: Introductionmentioning

confidence: 99%

Factors related to fatigue in Chinese patients with end-stage renal disease receiving maintenance hemodialysis: a multi-center cross-sectional study

Wang

Zang

et al. 2016

Renal Failure

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Risk factors for chronic kidney disease: an update

Cited by 525 publications

References 28 publications

A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

A Cross-Sectional Study on the Use of Urinalysis for Screening Early-Stage Renal Insufficiency

Activation of COX-2/mPGES-1/PGE2 Cascade via NLRP3 Inflammasome Contributes to Albumin-Induced Proximal Tubule Cell Injury

Factors related to fatigue in Chinese patients with end-stage renal disease receiving maintenance hemodialysis: a multi-center cross-sectional study

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