Risk factors for chronic kidney disease do not influence the serum levels of asymmetric dimethylarginine in HIV-1-infected patients without significant renal disease

Szymanek-Pasternak, Anna; Szymczak, Aleksandra; Zalewska, Małgorzata; Małyszczak, Krzysztof; Knysz, Brygida

doi:10.20452/pamw.3508

Cited by 1 publication

(1 citation statement)

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“…Presented analysis is a part of larger single-center study assessing kidney function in HIV-1-infected individuals, whereas other results of this study were published previously [27]. The study was conducted on 119 HIV-1-infected subjects, both on antiretroviral treatment and treatment-naïve, with negative history of kidney disease.…”

Section: Methodsmentioning

confidence: 99%

Assessment of urinary cystatin C levels in HIV-1-infected patients with preserved kidney function

Szymczak¹,

Szymanek-Pasternak²,

Zalewska³

et al. 2018

HIV & AIDS Review

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Introduction: Chronic kidney disease in one of the significant chronic conditions in human immunodeficiency virus (HIV)-infected population. The nephrotoxicity of antiretroviral therapy, particularly tenofovir disoproxil fumarate, is the important cause of kidney function impairment. There is a need to find reliable markers of early kidney damage. The aim of the study was to evaluate utility of urinary cystatin C levels as a marker of early kidney tubular damage in HIV-1-infected patients. Material and methods: A total of 119 HIV-1-infected patients (88 males, 74.0%) both on antiretroviral therapy (98 individuals, 82.4%) and treatment-naïve, without known kidney disease, and 31 healthy volunteers were enrolled. Cystatin C levels in urine were measured and urine cystatin C/creatinine ratio (UCCR) was calculated. Results: Significantly higher levels of urinary cystatin C were observed in HIV-1-infected group and subgroup on antiretroviral therapy with current CD4+ count below 500 cells/μl (p = 0.008 and p = 0.005, respectively). In patients with albuminuria, both urinary cystatin C and UCCR were significantly higher (p = 0.0035 and p < 0.001, respectively). HIV-1 infection, detectable HIV RNA, low CD4+ nadir, antiretroviral treatment or its length, use of tenofovir, or protease inhibitors had no influence on urinary cystatin C and UCCR. Conclusions: Low current CD4+ cell count was the only HIV-1-related factor influencing urinary cystatin C level. Use of tenofovir or other potentially nephrotoxic antiretroviral drugs did not have any impact on urinary cystatin C levels. Albuminuria was related to higher levels of urinary cystatin C but the background and relevance of this finding is unclear. Utility of urinary cystatin C assessment requires further research in large populations.

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Section: Methodsmentioning

confidence: 99%