Risk Factors for Chronic Pain Following Breast Cancer Surgery: A Prospective Study

Poleshuck, Ellen L.; Katz, Jennifer; Andrus, Carl H.; Hogan, Laura; Jung, Beth F.; Kulick, Dale I.; Dworkin, Robert H.

doi:10.1016/j.jpain.2006.02.007

Cited by 460 publications

(410 citation statements)

References 59 publications

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“…Factors such as age [9,22], female gender 1221, and opioid consumption have been identified as predictors of the transition to CPSP [4]. Our results failed to demonstrate such associations (Table 1).…”

Section: Introductioncontrasting

confidence: 75%

“…Studies have reported that female gender [9] and younger age [9,40) predicted intense acute postoperative pain, and nationwide surveys consistently find that the incidence of chronic neuropathic pain is significantly higher in women than men [4143]. Several smaller studies of CPSP have also identified younger age as a risk factor for the transition from acute pain to pain chronicity [14,22]. The sample of patients enrolled in the present study was quite homogeneous with respect to age and gender and neither predicted chronic pain 6 months after total hip arthroplasty [19].…”

Section: Introductionmentioning

confidence: 99%

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Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

et al. 2010

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Section: Introductioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

et al. 2010

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“…For example, chronic pain in breast cancer survivors is related to more invasive surgery, multiple treatments such as surgery combined with radiation, and post-operative pain (Poleshuck EL 2006). Treatment for head and neck cancers, the sixth most prevalent cancer globally, commonly leads to disfigurement, chronic pain and poor functional outcomes (Chin 2006).…”

Section: Discussionmentioning

confidence: 99%

Work disability associated with cancer survivorship and other chronic conditions

2007

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SummaryThe long-term effects of cancer and its treatment on employment and productivity are a major concern for the 40% of cancer survivors in the U.S. who are working age. This study's objectives were (1) to quantify the increase in work disability attributable to cancer in a cohort of adult survivors who were an average of 46 months post-diagnosis and (2) to compare disability rates in cancer survivors to individuals with other chronic conditions. Data from the Penn State Cancer Survivor Study (PSCSS) and the Health and Retirement Study (HRS) were compared. The PSCSS sample included 647 survivors age 55-65, diagnosed at four medical centers in Pennsylvania and Maryland. There were 5988 similarly aged subjects without cancer in the HRS. Adjusted odds ratios for work disability were estimated for cancer survivorship, heart disease, stroke, diabetes, lung disease, and arthritis/rheumatism with multivariate logistic regression. Even for cancer-free survivors, the disability rate was significantly higher in comparison to adults with no chronic conditions (female OR=1.94; male OR=1.89). There were few significant differences between disability rates for cancer and other conditions. The elevated disability rate is another argument for viewing cancer survivorship as a chronic condition potentially requiring a broad range of psychosocial services.

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“…Effective postoperative analgesia is of major importance for preventing POCP. 6,7 Gabapentin is known to reduce dorsal horn neuron excitability and central sensitization through various mechanisms. [8][9][10] A review of the literature suggested that the incidence of postoperative chronic pain was reduced through using gabapentin perioperatively.…”

Section: Introductionmentioning

confidence: 99%

Effect of preoperative gabapentin on pain intensity and development of chronic pain after carpal tunnel syndrome surgical treatment in women: randomized, double-blind, placebo-controlled study

et al. 2016

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Effect of preoperative gabapentin on pain intensity and development of chronic pain after carpal tunnel syndrome surgical treatment in women: randomized, double-blind, placebo-controlled study Efeito da gabapentina pré-operatória na intensidade da dor e desenvolvimento de dor crônica após o tratamento cirúrgico da síndrome do túnel do carpo em mulheres: estudo randomizado duplo-cego controlado com placebo METHODS: Forty patients aged 18 years or over were randomized into two groups: Gabapentin Group received 600 mg of gabapentin preoperatively, one hour prior to surgery, and Control Group received placebo. All the patients received intravenous regional anesthesia comprising 1% lidocaine. Midazolam was used for sedation if needed. Paracetamol was administered for postoperative analgesia as needed. Codeine was used additionally if the paracetamol was insufficient. The following were evaluated: postoperative pain intensity (over a six-month period), incidence of postoperative neuropathic pain (over a sixmonth period), need for intraoperative sedation, and use of postoperative paracetamol and codeine. The presence of neuropathic pain was established using the DN4 (Douleur Neuropathique 4) questionnaire. Complex regional pain syndrome was diagnosed using the Budapest questionnaire. RESULTS: No differences in the need for sedation, control over postoperative pain or incidence of chronic pain syndromes (neuropathic or complex regional pain syndrome) were observed. No differences in postoperative paracetamol and codeine consumption were observed. CONCLUSIONS: Preoperative gabapentin (600 mg) did not improve postoperative pain control, and did not reduce the incidence of chronic pain among patients undergoing carpal tunnel syndrome surgery. RESUMO CONTEXTO E OBJETIVOS:Analgesia pós-operatória eficaz é importante para reduzir a incidência de dor crônica. Este estudo avaliou o efeito da gabapentina pré-operatória na analgesia pós-operatória e na incidência de dor crônica em pacientes submetidos à cirurgia para tratamento da síndrome do túnel do carpo. DESENHO E LOCAL: Randomizado, duplo cego, Universidade Federal de São Paulo. MÉTODOS: Os 40 pacientes com 18 anos ou mais de idade foram distribuídos aleatoriamente em dois grupos: o Grupo Gabapentina recebeu 600 mg de gabapentina no pré-operatório uma hora antes da cirurgia, e o Grupo Controle recebeu placebo. Todos os pacientes receberam anestesia regional intravenosa com lidocaína a 1%. Midazolam foi utilizado para sedação, se necessário. Paracetamol foi administrado para analgesia pós-operatória, conforme necessário, e codeína, se o paracetamol fosse insuficiente. Foram avaliados: a intensidade da dor pós-operatória (durante seis meses), a incidência de dor neuropática pós-operatória (durante seis meses), a necessidade de sedação intra-operatória e o uso de paracetamol e codeína no pós-operatório. A presença de dor neuropática foi estabelecida utilizando-se o questionário DN4 (dor neuropática 4). Síndrome de dor regional complexa foi diagnosticada através do questionário ...

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Risk Factors for Chronic Pain Following Breast Cancer Surgery: A Prospective Study

Abstract: Clinical variables and severe acute pain were risk factors for chronic pain following breast cancer surgery, but psychosocial distress was not, which provides a basis for hypothesizing that aggressive management of acute postoperative pain may reduce chronic pain.

Cited by 460 publications

References 59 publications

Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

Acute pain after total hip arthroplasty does not predict the development of chronic postsurgical pain 6 months later

Work disability associated with cancer survivorship and other chronic conditions

Effect of preoperative gabapentin on pain intensity and development of chronic pain after carpal tunnel syndrome surgical treatment in women: randomized, double-blind, placebo-controlled study

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