Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

Nam, Soomin; Choi, Yoon Jung; Kim, Dong Wook; Park, Sohee; Kang, Jung Gu

doi:10.3393/ac.2019.10.21

Cited by 30 publications

(32 citation statements)

References 42 publications

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“…The incidence of nonadenocarcinoma in Korea was much lower than that of adenocarcinoma. The age-standardized incidence rates of colon adenocarcinoma in 2014 were 64.8 per 100,000 in men and 44.0 in women [13]. We also found that nonadenocarcinoma was relatively more frequent among younger patients than adenocarcinoma.…”

Section: Discussionsupporting

confidence: 56%

“…We also found that nonadenocarcinoma was relatively more frequent among younger patients than adenocarcinoma. The frequency of adenocarcinoma increases rapidly among patients in their 60s and is the highest among patients in their 60s, 70s, and 80s [13]. There has been little examination of the incidence and characteristics of colorectal nonadenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

et al. 2020

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Purpose: Although most colorectal malignancies are adenocarcinomas from mucosa, various types of malignant and benign tumors can develop. Due to extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors.Methods: Data from the Korea National Cancer Registry from 2007 to 2016 were used. The crude incidence, age-standard incidence rate (ASR) of colorectal nonadenocarcinomas were calculated.Results: Over 11 years, there were 267,142 patients with colorectal malignancies. The patients of 14,495 (5.43%) were diagnosed with nonadenocarcinoma. The ASR was 2.52 per 100,000 in men and 1.56 in women. Lesions were classified according to histologic categories; neuroendocrine tumor (NET) was the most common malignancy (10,919 [75.33%]). Nonadenocarcinoma was the most common in 40s and 50s (40 to 49 years, 3,530 [24.35%]; 50 to 59 years, 3,991 [27.53%]). Lymphoma was high (54.46%) in patients in teenagers. Proportion of NET decreased with age and that of carcinoma increased with age. Carcinoma, sarcoma, and lymphoma were more common among men and melanoma was more common among women. The most common site was the rectum (11,066 [76.34%]). Lymphoma occurred more frequently in proximal colon. Melanoma, gastrointestinal stromal tumor, and NET occurred mostly in rectum. A total of 10,155 patients (70.06%) were classified as having localized disease.Conclusion: This study is meaningful as it is the first study to examine incidence of colorectal nonadenocarcinoma. Differences in incidence of different lesions based on demographic factors were identified. This study will play a role in cancer prevention and diagnosis projects.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

et al. 2020

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“…The age-standardized incidence rates of colon adenocarcinoma in 2014 were 64.8 per 100,000 in men and 44.0 in women. [13] We also found that non-adenocarcinoma was relatively more frequent among younger patients than adenocarcinoma. The frequency of adenocarcinoma increases rapidly among patients in their 60s and is the highest among patients in their 60s, 70s, and 80s.…”

Section: A C C E P T E D a R T I C L Esupporting

confidence: 52%

Analysis of the incidence and clinical features of colorectal non-adenocarcinoma in Korea: A National Cancer Registry-based study

Nam¹,

Kim²,

Jung³

et al. 2020

Ann Coloproctol

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Although most colorectal malignancies are adenocarcinomas from colorectal mucosa, various types of malignant and benign tumors can develop, such as neuroendocrine tumors(NETs), gastrointestinal stromal tumors(GISTs), lymphomas, and sarcomas. Due to their extremely low incidence, little research has been conducted. The purpose was to assess incidence and compare it according to demographic factors using data from Korea National Cancer Registry. Method Data from the Korea National Cancer Registry from 2007 to 2016 were used. The crude incidence, age-standard incidence(ASR) of colorectal non-adenocarcinomas were calculated. Result Over 11 years, there were 267,142 patients with colorectal malignancies. 14,495 patients(5.43%) were diagnosed with non-adenocarcinoma. The ASR was 2.52 per 100,000 in men and 1.56 per 100,000 in women. Lesions were classified according to histologic categories: NET was the most common malignancy(n=10,919[75.33%]). Non-adenocarcinoma was the most common in their 40s and 50s(40-49:3,530[24.35%], 50-59:3,991[27.53%]). Lymphoma was high(54.46%) in patients in teenager. Proportion of NET decreased with age and that of carcinoma increased with age. Carcinoma, sarcoma, and lymphoma were more common among men and melanoma was more common among women. The most common site of nonadenocarcinoma was the rectum(n=11,066[76.34%]). Lymphoma occurred more frequently in proximal colon. Melanoma, GIST, and NET occurred mostly in rectum. 10,155 patients(70.06%) were classified as having localized disease. Conclusion This study is meaningful as it is the first study to examine incidence of colorectal nonadenocarcinoma. Differences in incidence of different lesions based on demographic factors were identified. This study will play a role in cancer prevention and diagnosis projects.

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“…Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and one of the leading causes of cancer-specific death [9], with more than 1.1 million cancer deaths expected by 2030 [10]. According to the published studies, diet [11], obesity [12], alcohol intake [13] and diabetes [14] are all risk factors for the occurrence and mortality in patients with CRC. Since 2001, several epidemiological studies have investigated the association between MetS and CRC risk but showed inconsistent results.…”

Section: Ivyspringmentioning

confidence: 99%

The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis

Han¹,

Wu²,

Zhang³

et al. 2021

Int. J. Biol. Sci.

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Background: This meta-analysis was aimed to quantitatively assess the associations of metabolic syndrome (MetS) and its components with colorectal cancer (CRC). Methods: PubMed, EMBASE and Web of Science databases were systematically searched for eligible studies. A total of 18 studies for CRC incidence and 12 studies for CRC mortality were identified. Results: MetS was associated with an increased risk of CRC incidence and mortality in male (RR: 1.28, 95 % CI 1.16-1.39, and 1.24, 1.18-1.31, respectively) and correlated with an increased risk of CRC incidence in female (RR: 1.21, 1.13-1.30), but not with CRC mortality in female. MetS increased the risk of cancer-specific mortality (RR: 1.72, 1.03-2.42), but not overall mortality. The risk estimates of CRC incidence changed little depending on age, sex, cancer site, the type of studies, ethnicity, publication year, or definition of MetS. As for CRC mortality, further stratified analyses indicated statistical significance in studies with assessing cancer-specific survival outcome, in male, a cohort design, ethnicity of non-Chinese or with definition of MetS as ≥ 3 metabolic abnormalities. Obesity and hyperglycemia are risk factors of CRC incidence in both male and female. Only dysglycemia is the risk factor for CRC mortality. Conclusions: MetS is associated with an increased risk of CRC incidence and cancer-specific mortality, but not overall mortality. In addition, MetS may increase the CRC mortality in male rather than in female. However, since most of the studies on CRC mortality were conducted in Chinese, further studies are needed to clarify this connection.

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Risk Factors for Colorectal Cancer in Korea: A Population-Based Retrospective Cohort Study

Cited by 30 publications

References 42 publications

Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

Analysis of the Incidence and Clinical Features of Colorectal Nonadenocarcinoma in Korea: A National Cancer Registry-Based Study

Analysis of the incidence and clinical features of colorectal non-adenocarcinoma in Korea: A National Cancer Registry-based study

The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis

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