Risk Factors for Congenital Syphilis Transmitted from Mother to Infant — Suzhou, China, 2011–2014

Wang, Yajie; Wu, Minna; Gong, Xia; Zhao, Liang; Zhao, Jing; Zhu, Chuan-Wu; Gong, Chancong

doi:10.15585/mmwr.mm6810a4

Cited by 34 publications

(54 citation statements)

References 7 publications

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“…In our study, the untreated rate of maternal syphilis infection was significantly higher (74.5%) than other reports at home and abroad [5,33]. Studies have shown that serious adverse pregnancy outcomes such as abortion, stillbirth still have a certain prevalence rate of 15.1% (41/271), lower than the abortion and stillbirth rate of maternal syphilis in 2012, 15.4% [34]. This study also found that the risk of APOs in the 30-34 age group is higher than the ≤24 age group, which is not the same as some reports at home and abroad [35,36], this may be related to the average age of the study population (27.0) is greater than other similar studies [37].…”

Section: Prevalence and Related Factors Of Pregnancy Syphilis Compliccontrasting

confidence: 58%

Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

Yang

Sun

et al. 2019

Preprint

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Background. It is of great public health significance to monitor the global meiosis mother-to-child transmission plan proposed by WHO and monitor the prevalence of maternal syphilis and the factors affecting mother-to-child transmission. Methods. We collected 271 medical records of prenatally diagnosed (from 87286 pregnant women) of syphilis among pregnant women a maternity hospital in Jilin Province China from 2013 to 2017. The chi-square test and Logistic multiple regression analysis were used to describe the clinical characteristics of pregnant women with syphilis and the related factors of adverse pregnancy outcome. Results. The average prevalence of maternal syphilis is 0.31% (95%[CI]: 0.27%-0.35%). The mean age of 271 pregnant women with syphilis is 27.62±5.4 years old. The maternal syphilis prevalence of absence of paid occupation is 73.8%; rural population accounts for 43.6%. Maternal women with a history of abortion accounted for 43.1%, of which 53.1% had abortion ≥2; The average rate of treatment in pregnancy is 25.5% (95%[CI]: 25.4%-25.6%). The prevalence rate of APOs are 43.9% (95%[CI]: 38.1%-49.9%), declined in five years (P<0.05). APOs was significantly higher in women at 30–34 age group than that in 0-24 age group (OR= 2.916, 95%CI: 1.298-6.549) and higher in Un-treatment in pregnancy than that in receive treatment (OR=2.469, 95%CI:1.225-4.975). PROM occurrence (OR=2.702, 95%CI:1.219-5.988); CRP elevation (≥10 mg/L) and RPR high titer (≥1:8) are related to the occurrence of APOs. Abortion, prematurity and low birth weight are associated with no treatment during pregnancy (P<0.05). Comparison of 42 cases of pregnancy-induced hypertension and non-pregnancy-induced hypertension, Dysmenorrhea (OR= 3.654, 95%CI:1.812-7.369) and elevated urine protein (OR= 2.259, 95%CI:1.161-4.394) are the influencing factors of maternal syphilis complicated with pregnancy-induced hypertension. Conclusions. The prevalence of maternal syphilis in northern China is lower than that of 10 years ago, but the decline is still lower than that in the economically developed regions of the south. The rate of non-treatment of syphilis during pregnancy is high, and should be alert to the rebound of maternal syphilis.

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Section: Prevalence and Related Factors Of Pregnancy Syphilis Compliccontrasting

confidence: 58%

Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

Yang

Sun

et al. 2019

Preprint

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“…However, improving the quality of health services to prevent the vertical transmission of T. pallidum in Brazilian pregnant women is still a challenge 16 . Our study identified a higher incidence rate of congenital syphilis than reported in other studies [17][18][19][20][21] . In addition, we showed that socio-economic variables, such as low income and poor education were frequent in this population, in agreement with those reported in the USA, China and Argentina [22][23][24] , possibly reflecting inequalities in self-care, as well as difficulties to access and perform follow-ups in health services.…”

Section: Discussionsupporting

confidence: 47%

Neurosyphilis in Brazilian newborns: a health problem that could be avoided

Ribeiro

Dan

Santos

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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“… 10 A reactive serological test before age 18 months does not necessarily indicate that the infant is infected. 11 A broad spectrum of severity exists, from inapparent infection to severe cases that are present at birth. 12 Therefore, diagnostic misclassification of CS in clinical practice is not uncommon.…”

Section: Introductionmentioning

confidence: 99%

New screening approach to detecting congenital syphilis in China: a retrospective cohort study

Guo

et al. 2020

Arch Dis Child

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BackgroundDiagnosis of congenital syphilis (CS) is not straightforward and can be challenging. This study aimed to evaluate the validity of an algorithm using timing of maternal antisyphilis treatment and titres of non-treponemal antibody as predictors of CS.MethodsConfirmed CS cases and those where CS was excluded were obtained from the Guangzhou Prevention of Mother-to-Child Transmission of syphilis programme between 2011 and 2019. We calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) using receiver operating characteristics (ROC) in two situations: (1) receiving antisyphilis treatment or no-treatment during pregnancy and (2) initiating treatment before 28 gestational weeks (GWs), initiating after 28 GWs or receiving no treatment for syphilis seropositive women.ResultsAmong 1558 syphilis-exposed children, 39 had confirmed CS. Area under the curve, sensitivity and specificity of maternal non-treponemal titres before treatment and treatment during pregnancy were 0.80, 76.9%, 78.7% and 0.79, 69.2%, 88.7%, respectively, for children with CS. For the algorithm, ROC results showed that PPV and NPV for predicting CS were 37.3% and 96.4% (non-treponemal titres cut-off value 1:8 and no antisyphilis treatment), 9.4% and 100% (non-treponemal titres cut-off value 1:16 and treatment after 28 GWs), 4.2% and 99.5% (non-treponemal titres cut-off value 1:32 and treatment before 28 GWs), respectively.ConclusionsAn algorithm using maternal non-treponemal titres and timing of treatment during pregnancy could be an effective strategy to diagnose or rule out CS, especially when the rate of loss to follow-up is high or there are no straightforward diagnostic tools.

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Risk Factors for Congenital Syphilis Transmitted from Mother to Infant — Suzhou, China, 2011–2014

Cited by 34 publications

References 7 publications

Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

Pregnancy syphilis epidemic trends, clinical features, APOs risk factors, pregnancy-induced hypertension epidemics and related factors, in Northeast China Jilin Maternity Hospital 2013-2017

Neurosyphilis in Brazilian newborns: a health problem that could be avoided

New screening approach to detecting congenital syphilis in China: a retrospective cohort study

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