Risk Factors for Corneal Striae in Eyes After Glaucoma Surgery

Abstract

Précis: Eyes with corneal striae had steeper cornea, induced astigmatism, and higher corneal hysteresis (CH), which implies a relationship between striae, corneal shape, and the cornea's resistance to deformation at low intraocular pressures (IOPs).Background: Anterior corneal striae (ACS) are associated with low IOP. However, the clinical significance of ACS is unclear. Here, we aim to evaluate differences in eyes with striae compared with eyes without striae.Methods: Adults with ACS (cases) and without ACS (controls) ≥ 8 weeks after glaucoma surgery with an IOP ≤ 10 mm Hg were enrolled. Optical coherence tomography and optical biometry were performed. CH, defined as the difference in pressure between corneal indentation and reformation in response to an air jet, was obtained by the ocular response analyzer. Hypotony maculopathy (HM) was defined as optic disc swelling, vascular tortuosity attributed to hypotony, or clinical presence of chorioretinal folds confirmed on OCT.Results: One hundred sixteen eyes (76 cases, 40 controls) were included. Cases had a lower IOP compared with controls (6.5 ± 2.3 vs. 8.5 ± 1, P < 0.0001). A 1 mm Hg increase in CH increased ACS odds [odds ratio (OR) = 1.51, P = 0.01]. A 1 D increase in the flattest presurgical and postsurgical corneal power increased ACS odds by 1.83 (P = 0.01) and 1.41 (P = 0.02), respectively. Astigmatism increased in eyes with ACS by 1.11 D (P < 0.001). ACS odds were increased with every 1 minute increase in mitomycin-C duration (OR = 1.58, P = 0.047) and decreased with the use of topical glaucoma medication (OR = 0.62, P = 0.03). Visual acuity decreased from logarithm of the minimal angle of resolution 0.22 (20/33 Snellen) presurgery to 0.28 (20/38) postsurgery (P = 0.008), independent of ACS. HM occurred in 19% of cases (P = 0.05). A higher postsurgical CH increased HM odds (OR = 1.8, P = 0.003). HM predicted a 0.41 mm decrease in axial length (P < 0.0001), independent of IOP.Conclusion: ACS were associated with a steeper cornea, induced astigmatism, and higher CH, suggesting a relationship between striae, corneal shape, and the cornea's ability to resist deformations at lower IOP. CH, HM, and axial length shortening were associated independently of IOP.

Clinical Significance of Corneal Striae in Thyroid Associated Orbitopathy

“…Previous studies on corneal striae were associated with abnormal intraocular pressure, especially with low IOP being reported [ 25 , 26 ]. In this study, the IOP (including in primary and upgaze) was not associated with corneal striae.…”