Risk factors for critical and complex congenital heart diseases: Case-control study

Lopes, Selma Alves Valente do Amaral; Guimarães, Isabel Cristina Brito; Costa, Sofia Fontes de Oliva; Acosta, Angelina Xavier; Abe‐Sandes, Kiyoko; Mendes, Carlos Maurício Cardeal

doi:10.1016/j.ppedcard.2022.101612

Cited by 2 publications

(1 citation statement)

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“…Although there are now more clearly defined risk factors, the cause of most CHDs is still unknown. A well-established causal relationship can only be defined in 10 to 15% of cases [4]. The Disclaimer/Publisher's Note: The statements, opinions, and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s).…”

Section: Introductionmentioning

confidence: 99%

From Detection to Action: A Retrospective Analysis on the Impact of Screening for Congenital Heart Disease in the NICU

Roșca,

Popescu,

Jura

et al. 2024

Preprint

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Congenital heart disease (CHD) is a prevalent congenital disorder diagnosed with high frequency, affecting approximately 0.8% to 1.2% of all live births. Research has demonstrated that the use of pulse oximetry and clinical examination as a screening tool for CHD diagnosis has proven extremely valuable. We conducted a retrospective longitudinal study over a 3-year period that involved screening 1188 newborns admitted to the NICU during the first 72 hours of life within this timeframe. 201 newborns were diagnosed with CHD. Almost all (n=198) had a positive screening test during the 72-hour period, while 3 had a negative screening test, but were later diagnosed using echocardiography. The prevalence rate was 16.67%. A confusion matrix was constructed with 198 true positives (TP), 3 false negatives (FN), no false positives (FP), and 987 true negatives (TN). The sensitivity of the screening test was 98.51%, while the specificity 100%, with no false positives. In our study, a total of 9 deaths occurred. Using the Kaplan-Meier method, the survival probability appeared to be slightly above 0.9 (95.5%), indicating that almost all patients survived past 72 hours after being diagnosed with CHD. Pulse oximetry is an effective, low cost and easy-to-use method and a useful tool to assess and lead to the diagnosis of CHD.

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Section: Introductionmentioning

confidence: 99%