Risk factors for death in suspected severe bacterial infection in infants aged <90 days in Luanda, Angola

Abstract

Background: Yearly, about two million infants die during the first 28 days of life. Most of these deaths occur in sub-Saharan Africa and a third of those are caused by severe infections. The early identification of infants at risk of death is important when trying to prevent poor outcomes. Objective: The aim of this study was to identify risk factors for death among young infants with possible serious bacterial infection (pSBI) at hospital admission. Methods: This prospective, observational, single-site, descriptive study forms part of a larger study on bacterial meningitis in infants <90 days of age admitted to the Pediatric Hospital of Luanda, the capital of Angola, from February 1, 2016 to October 23, 2017. Infants with pSBI, a known outcome, and a final diagnosis were included. Results: Of 574 young infants with pSBI, 115 (20%) died in hospital. An altered level of consciousness, absence of spontaneous movements, dyspnea, CSF that is not clear, low CSF glucose, high CSF protein, heart rate over the median, and seizures were identified as risk factors for death in the univariate analysis. In the multivariate analysis, only heart rate over the median and seizures were independent predictors of death. Conclusions: Easily recognizable clinical signstachycardia and seizuresmay guide clinicians to identify infants at high risk of death due to severe bacterial infections in sub-Saharan Africa.

Global Case Fatality of Bacterial Meningitis During an 80-Year Period

“…The design was observational in 330 studies (94%) and interventional in 20 (6%) studies, with 12 to 22 831 (median [IQR], 115 [61-270]) episodes per study, and the inclusion period’s length varying from 3 months to 36 years (median [IQR], 5 [2-10] years). Studies included neonates (59 studies [16%]; 6549 episodes [4%]), children (101 studies [27%]; 21 511 episodes [14%]), adults (64 studies [17%]; 15 362 episodes [10%]), neonates and children (68 studies [18%]; 26 992 episodes [17%]),…”

“…The design was observational in 330 studies (94%) and interventional in 20 (6%) studies, with 12 to 22 831 (median [IQR], 115 [61-270]) episodes per study, and the inclusion period’s length varying from 3 months to 36 years (median [IQR], 5 [2-10] years). Studies included neonates (59 studies [16%]; 6549 episodes [4%]), 25 , 29 , 32 , 38 , 42 , 43 , 45 , 49 , 55 , 63 , 70 , 86 , 93 , 97 , 101 , 105 , 121 , 126 , 127 , 132 , 133 , 138 , 142 , 157 , 159 , 160 , 196 , 200 , 212 , 214 , 216 , 220 , 235 , 241 , 258 , 275 , 281 , 294 , 297 , 299 , 307 , 319 , 321 , 323 , 324 , 336 , 340 , 345 , 346 , 358 , 365 , 368 , 373 , 377 , 379 , 382 , ...…”

Biogenic synthesis of ZnO and Al2O3 nanoparticles using Camellia sinensis and Origanum vulgare L. leaves extract for spectroscopic estimation of ofloxacin and ciprofloxacin in commercial formulations

“…These diseases can be transmitted to humans or animals through direct or indirect contact with the source of infection [ 2 ]. Unsuitable or unregulated pharmaceutical doses are one of the main causes of death worldwide, particularly among children and young people [ 3 ].…”

“…These diseases can be transmitted to humans or animals through direct or indirect contact with the source of infection [2]. Unsuitable or unregulated pharmaceutical doses are one of the main causes of death worldwide, particularly among children and young people [3]. Antibacterial drugs have recently been utilized to reduce or kill the growth of a variety of Gram-positive and Gram-negative infections [4].…”