Risk factors for development of diabetes mellitus, hypertension and dyslipidemia

Fukui, Michiaki; Tanaka, Muhei; Toda, Hitoshi; Senmaru, Takafumi; Sakabe, Kazumi; Ushigome, Emi; Asano, Mai; Yamazaki, Masahiro; Hasegawa, Goji; Imai, Saeko; Nakamura, Naoto

doi:10.1016/j.diabres.2011.07.006

Cited by 31 publications

(25 citation statements)

References 15 publications

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“…This supports the results from previous longitudinal studies in men,38 39 women40 41 and adults 32 42. The risk of hypertension increased with an increase in the total cholesterol, triglyceride and low-density lipoprotein cholesterol levels and decreased with an increase in the high-density lipoprotein cholesterol level 38 39 41.…”

Section: Discussionsupporting

confidence: 89%

“…This finding is consistent with the longitudinal studies in the USA,30 31 which reported that in diabetic patients the risk of incident hypertension rose by 41% and 56%, respectively. In addition, prospective cohort studies in Japan showed that diabetes32 and impaired fasting blood glucose33 were associated with an increased risk of hypertension incidence. Supportive cross-sectional results emerge from studies in diverse settings including Bangladesh and India,34 Barbados35 and the USA 36.…”

Section: Discussionmentioning

confidence: 99%

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Health risk factors and the incidence of hypertension: 4-year prospective findings from a national cohort of 60 569 Thai Open University students

Looze¹,

Reid

Seubsman

et al. 2013

BMJ Open

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ObjectiveThis study evaluates the impact of a number of demographic, biological, behavioural and lifestyle health risk factors on the incidence of hypertension in Thailand over a 4-year period.DesignA 4-year prospective study of health risk factors and their effects on the incidence of hypertension in a national Thai Cohort Study from 2005 to 2009.SettingAs Thailand is transitioning from a developing to a middle-income developed country, chronic diseases (particularly cardiovascular disease) have emerged as major health issues. Hypertension is a major risk factor for heart attack and stroke and cross-sectional studies have indicated that the prevalence is increasing.Study participantsA total of 57 558 Sukhothai Thammathirat Open University students who participated in both the 2005 and 2009 questionnaire surveys and who were normotensive in 2005 were included in the analysis.MeasuresAdjusted relative risks associating each risk factor and incidence of hypertension by sex, after controlling for confounders such as age, socioeconomic status, body mass index (BMI) and underlying diseases.ResultsThe overall 4-year incidence of hypertension was 3.5%, with the rate in men being remarkably higher than that in women (5.2% vs 2.1%). In both sexes, hypertension was associated with age, higher BMI and comorbidities but not with income and education. In men, hypertension was associated with physical inactivity, smoking, alcohol and fast food intake. In women, hypertension was related to having a partner.ConclusionsIn both men and women, hypertension was strongly associated with age, obesity and comorbidities while it had no association with socioeconomic factors. The cohort patterns of socioeconomy and hypertension reflect that the health risk transition in Thais is likely to be at the middle stage. Diet and lifestyle factors associate with incidence of hypertension in Thais and may be amenable targets for hypertension control programmes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Health risk factors and the incidence of hypertension: 4-year prospective findings from a national cohort of 60 569 Thai Open University students

Looze¹,

Reid

Seubsman

et al. 2013

BMJ Open

View full text Add to dashboard Cite

show abstract

“…The follow-up period was 1–15 years, and participants were followed monthly up to 10 years. Three studies based the definition of incident type 2 diabetes on self-reports only [14,47,48], 10 on laboratory data only (fasting glucose levels, casual glucose levels, 2-h post-load glucose levels after oral glucose tolerance tests, or HbA1c levels) [15,49-57], and 20 on self-reports and laboratory data [50,58–76]. Nine studies were population-based studies [14,47,49,51,53,64,68,69,77] with participation rates varying from 40.9% to 85.3%.…”

Section: Resultsmentioning

confidence: 99%

Incidence of Type 2 Diabetes in Japan: A Systematic Review and Meta-Analysis

Goto

Noda

et al. 2013

PLoS ONE

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BackgroundThe definition of incident type 2 diabetes varies across studies; hence, the actual incidence of type 2 diabetes in Japan is unclear. Here, we reviewed the various definitions of incident type 2 diabetes used in previous epidemiologic studies and estimated the diabetes incidence rate in Japan.MethodsWe searched for related literature in the MEDLINE, EMBASE, and Ichushi databases through September 2012. Two reviewers selected studies that evaluated incident type 2 diabetes in the Japanese population.ResultsFrom 1824 relevant articles, we included 33 studies with 386,803 participants. The follow-up period ranged from 2.3 to 14 years and the studies were initiated between 1980 and 2003. The random-effects model indicated that the pooled incidence rate of diabetes was 8.8 (95% confidence interval, 7.4–10.4) per 1000 person-years. We observed a high degree of heterogeneity in the results (I2 = 99.2%; p < 0.001), with incidence rates ranging from 2.3 to 52.6 per 1000 person-years. Three studies based their definition of incident type 2 diabetes on self-reports only, 10 on laboratory data only, and 20 on self-reports and laboratory data. Compared with studies defining diabetes using laboratory data (n = 30; pooled incidence rate = 9.6; 95% confidence interval = 8.3–11.1), studies based on self-reports alone tended to show a lower incidence rate (n = 3; pooled incidence rate = 4.0; 95% confidence interval = 3.2–5.0; p for interaction < 0.001). However, stratified analyses could not entirely explain the heterogeneity in the results.ConclusionsOur systematic review and meta-analysis indicated the presence of a high degree of heterogeneity, which suggests that there is a considerable amount of uncertainty regarding the incidence of type 2 diabetes in Japan. They also suggested that laboratory data may be important for the accurate estimation of the incidence of type 2 diabetes.

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“…Hypertension and dyslipidemia, both widely recognized risk factors for T2DM, 29,30 have been proposed to contribute to the development of OA. 31–33 It has been theorized that hypertension might affect OA via narrowing of blood vessels and subchondral ischemia, which would initiate cartilage degradation.…”

Section: Shared Risk Factors For Oa and T2dmmentioning

confidence: 99%

Links Between Osteoarthritis and Diabetes

Piva

Susko

Khoja

et al. 2015

Clinics in Geriatric Medicine

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SYNOPSIS Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often co-exist in older adults. There is increased susceptibility to develop arthritis in those with T2DM, which is supported by observations of higher prevalence of arthritis in those with T2DM (52%) compared to those without it (27%). The association between OA and T2DM has been traditionally attributed to underlying shared risk factors of age and obesity. Emerging evidence suggests that alterations in lipid metabolism and hyperglycemia might have a direct impact on cartilage health and subchondral bone that contribute to the development and/or progression of OA. Adequate management of older persons with both OA and T2DM benefits from a comprehensive understanding of the risk factors associated with these diseases. In this review, we discuss common risk factors and emerging underlying links between OA and T2DM, and emphasize the importance of physical activity to improve metabolism and decrease disability and pain in this population. Implications for safe and effective physical activity approaches in older patients with OA and T2DM are also discussed.

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Risk factors for development of diabetes mellitus, hypertension and dyslipidemia

Cited by 31 publications

References 15 publications

Health risk factors and the incidence of hypertension: 4-year prospective findings from a national cohort of 60 569 Thai Open University students

Health risk factors and the incidence of hypertension: 4-year prospective findings from a national cohort of 60 569 Thai Open University students

Incidence of Type 2 Diabetes in Japan: A Systematic Review and Meta-Analysis

Links Between Osteoarthritis and Diabetes

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