2023
DOI: 10.1177/17085381231154805
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Risk factors for diabetic foot ulcers: A systematic review and meta-analysis

Abstract: Objective To systematically evaluate the risk factors for developing diabetic foot ulcers (DFU). Methods The Cochrane Library, PubMed, Web of Science, SinoMed, CNKI, VIP, and Wanfang Data were searched for relevant studies on DFU risk factors, and the search time frame was from database creation to March 2022. Meta-analysis was performed using RevMan 5.3. Results A total of 26 publications were included, including 3 cohort studies, 22 case–control studies, and one cross-sectional study. Meta-analysis showed th… Show more

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Cited by 13 publications
(13 citation statements)
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References 38 publications
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“…Nevertheless, there are studies that report worse lipid composition in individuals with T2D and DFU. 30,31 In our study, there was no association between BP and DFU or amputations. Previous studies reported conflicting results for the association between BP and DFU.…”
Section: Discussioncontrasting
confidence: 57%
See 1 more Smart Citation
“…Nevertheless, there are studies that report worse lipid composition in individuals with T2D and DFU. 30,31 In our study, there was no association between BP and DFU or amputations. Previous studies reported conflicting results for the association between BP and DFU.…”
Section: Discussioncontrasting
confidence: 57%
“…According to the DPV data, one could assume that metabolic parameters might be a risk factor only in this specific subgroup and therefore it might be helpful to closely monitor lipid levels in T1D people at higher risk for DFU. Nevertheless, there are studies that report worse lipid composition in individuals with T2D and DFU 30,31 …”
Section: Discussionmentioning
confidence: 99%
“…[25] Similarly, in a metaanalysis published by Tang et al, HbA 1c level was shown to be one of the factors predicting the development of DFU. [26] The results of the present study revealed a significant correlation between the high HbA 1c values on presentation with the severity of diabetic foot, the surgical procedures applied, and the level of tissue loss present in the patients with diabetic foot. A meta-analysis involving 60 observational studies and 12,604 diabetic foot patients, suggest that A1c levels ≥8% and fasting glucose levels ≥126 mg/dL are associated with an increased likelihood of lower extremity amputation in patients with diabetic foot.…”
Section: Discussionsupporting
confidence: 51%
“…These causative factors are more likely present in the geriatric population [55]. The risk factors for developing DFU in patients with diabetes include older age, increased BMI, duration of diabetes, and comorbidities that include neuropathy, nephropathy, or retinopathy [56]. When sensory neuropathy is present, normal pressure/pain signals are diminished or absent, removing warning signs or symptoms of tissue injury.…”
Section: Diabetes-related Risk Factorsmentioning
confidence: 99%