Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma

Wu, Jaw–Ching; Huang, Yi Hsiang; Chau, Gar‐Yang; Su, Chien–Wei; Lai, CL; Lee, Pui–Ching; Huo, Teh–Ia; Sheen, I–Jane; Lee, Shou‐Dong; Lui, Wing‐Yiu

doi:10.1016/j.jhep.2009.07.009

Cited by 393 publications

(407 citation statements)

References 42 publications

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“…We recently found that tumor factors were predictive of early recurrence within 2 years after surgery, while viral factors and ''field factors'' in non-tumor parts influenced late recurrence [19]. The impact of field factors may be overwhelmed by the tumor factors in advanced HCC.…”

Section: Discussionmentioning

confidence: 99%

“…This study is the subsequent cohort analysis from one prospectively conducted, retrospectively analyzed study, which enrolled 193 HBV-related HCC patients who underwent tumor resection in Taipei Veterans General Hospital from 1990 to 2002 [19]. We further analyzed a total of 76 patients with small and solitary HCC in this cohort.…”

Section: Patients and Follow-upmentioning

confidence: 99%

“…Detection and quantification of HBV DNA and genotyping and sequencing of HBV Serum HBV DNA was detected by semi-nested polymerase chain reaction (PCR) as previously described and HBV DNA levels were measured by a Cobas Amplicor HBV monitor (Roche Diagnostic System, Basel, Switzerland) [19,21]. The detection limit of this assay was 300 copies/ mL.…”

Section: Biochemical and Serological Markersmentioning

confidence: 99%

“…The detection limit of this assay was 300 copies/ mL. Genotyping of HBV was performed by PCR restriction fragment length polymorphism of the surface gene of HBV and further verified by sequencing [19,21].…”

Section: Biochemical and Serological Markersmentioning

confidence: 99%

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Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Hung

Lai

et al. 2010

Hepatol Int

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Purpose Although advanced liver fibrosis is crucial in the development of hepatocellular carcinoma (HCC) for patients with chronic hepatitis B, whether it is associated with the recurrence of HCC after resection remains obscure. This study was aimed to compare the outcomes for patients with minimal or advanced fibrosis in solitary small hepatitis B virus (HBV)-related HCC.Methods This study enrolled 76 patients with small (\5 cm) solitary HBV-related HCC who underwent resection. The outcomes of patients with minimal and advanced fibrosis in non-tumor areas were compared. Serum markers were tested to assess the stage of hepatic fibrosis and to predict prognosis. Results Fourteen patients with an Ishak fibrosis score of 0 or 1 were defined as having minimal fibrosis; the remaining 62 patients were defined as having advanced fibrosis. During a follow-up period of 77.0 ± 50.7 months, 41 patients died. The overall survival rate was significantly higher (P = 0.018) and recurrence rate was lower

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Section: Discussionmentioning

confidence: 99%

Section: Patients and Follow-upmentioning

confidence: 99%

Section: Biochemical and Serological Markersmentioning

confidence: 99%

Section: Biochemical and Serological Markersmentioning

confidence: 99%

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Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Hung

Lai

et al. 2010

Hepatol Int

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“…Previous studies have identified various risk factors for early and late recurrence in patients with HCC. Early recurrence after resection for HCC is likely to be associated with aggressive tumor biology , especially macro or microscopic vascular infiltration (Portolani et al, 2006;Wu et al, 2009), whereas late recurrence is likely to be associated with the presence of cirrhosis (Poon et al, 2000;Portolani et al, 2006) and hepatitis virus infection (Wu et al, 2009;Muscari et al, 2011). Most of the them were performed in unselected patients ,including patients with macrovascular invasion and/or multiple tumors.…”

Section: Risk Factors For Early and Late Intrahepatic Recurrence In Pmentioning

confidence: 99%

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Li¹,

Guo²,

Xiao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Association Between Nucleoside Analogues and Risk of Hepatitis B Virus–Related Hepatocellular Carcinoma Recurrence Following Liver Resection

Wu¹,

Chen²,

Ho³

et al. 2012

JAMA

765

646

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Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma

Cited by 393 publications

References 42 publications

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Fibrosis and AST to platelet ratio index predict post-operative prognosis for solitary small hepatitis B-related hepatocellular carcinoma

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Association Between Nucleoside Analogues and Risk of Hepatitis B Virus–Related Hepatocellular Carcinoma Recurrence Following Liver Resection

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