Risk Factors for Early-Onset Colorectal Cancer

Abstract

Risk Factors for Early-Onset Colorectal Cancer Study GroupResults Clini al FindingVeterans 18 -49 years of age undergoing colonoscopy loss may be an early clinical sign of early-onset colorectal cancer

Gut Microbiota and Colorectal Cancer Development: A Closer Look to the Adenoma-Carcinoma Sequence

“…A diet rich in fiber, vitamin B6, C, D, E, folic acid, magnesium and selenium, has also been suggested to decrease the risk of CRC [ 44 ]. Other risk factors that may contribute to the development of CRC are obesity, smoking, male sex, non-hispanic black ethnicity, and lack of physical activity [ 45 , 46 , 47 ].…”

Emerging trends in colorectal cancer: Dysregulated signaling pathways (Review)

“…No statistically significant difference in the disease-free survival between these 2 groups has been demonstrated over the past 5 years (63.2% in both the young and elderly group) (53). Between 1992 and 2014, there was a significant increase in the number of young male patients with cRc than older patients ( (59). Rectal cancer has a higher chance of developing into EOcRc than colon cancer, whereas, in late-onset cases, obesity is the major risk factor for colon cancer (61,62).…”

Understanding Characteristics of Who Undergoes Testing Is Crucial for the Development of Diagnostic Strategies to Identify Individuals at Risk for Early-age Onset Colorectal Cancer

“…For example, although iron deficiency anemia and weight loss are considered red flag symptoms in individuals who present with gastrointestinal complaints, only 15% of individuals with either of these symptoms underwent evaluation within 1 year. Subtle weight loss has previously been associated with EOCRC, 21 so the ascertainment and appropriate evaluation of this symptom may be an important factor in improving EOCRC outcomes. Furthermore, among individuals with rectal bleeding, 41% were not evaluated and 23% underwent initial evaluation by FIT, FOBT, or cross-sectional imaging.…”