Risk Factors for Endometrial Hyperplasia and Cancer in Patients with Abnormal Uterine Bleeding in Al-Zahrawi Hospital

Abstract

Aim and background: The study aims to detrmaine the risk factors for endometrial hyperplasia and endometrial cancer in patient with abnormal uterine bleeding and thus early diagnositric investigations to detect the disease and limit its development Methods: The study sample includes women attending AL-zhrawi Hospital with acomplaint of abnormal uterine bleeding and who fulfilled the entry criteria. The women in the sample were divided according to the result of the pathological autopsy into : The first group “control group” : it the the group that showed normal endometrioses by histopathology . The second group “cases group” : it is divided into two categories: the first category it is the group that showed endometrial hyperplasia through histopathology. The second category : the category that showed the presence of endometrial cancer through histopathology. Results: The mean age in the endometrial cancer group was 58.6 ± 6.5 years, the BMI value was expressed as the arithmetic mean of values for each group, and the highest mean in the cancer group was 28.75 kg/m2. The differences between the endometrial and control groups and the two hyperplastic groups The control is statistically significant with a P value of 0.001, and 60% of endometrial cancer patients were in menopause, and this is associated with hormonal changes accompanying the age of transition to menopause, and 45% of them were not giving birth. 35% of patients with cancer were found in this study. Endometriosis have diabetes, and this value was statistically significant compared to the control group with (P<0.05), and arterial hypertension was recorded in 80% of our patients, and it was statistically significant (P<0.05), a family history was found. of endometrial cancer in 50% of endometrial cancer patients, and half of the cases were in the mother and the other half in the sister. Conclusion: In this study, according to the set conditions, 123 women suffering from abnormal uterine bleeding were recruited. The number of diagnosed endometrial cancer cases was 20, and each of the following factors was statistically significant for the development of endometrial cancer: advanced age - high BMI - early puberty - anuria - female childbirth - the presence of a family history of endometrial cancer - diabetes mellitus - High arterial pressure, while the following factors were not statistically significant: Increased number of births - Intensity of vaginal bleeding