Risk Factors for Endometrial Hyperplasia Concomitant Endometrial Polyps in Pre- and Post-menopausal Women

Topçu, Hasan Onur; Erkaya, Salım; Güzel, Ali İrfan; Kokanali, Mahmut Kuntay; Sarıkaya, Esma; Muftuoglu, Kamil Hakan; Doğanay, Melike

doi:10.7314/apjcp.2014.15.13.5423

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…We were able to find only a few publications on combinations of EP with other endometrial and endocervical abnormalities in available literature. In particular, Topcu et al found a combination of EP with EH without atypia in 5.9 % of endometrial samples and a combination with AEH in 0.5 % of cases [25]. In the Danish Civil Registration System, 9.4 % of premenopausal women have a combination of EP and cervical canal polyps [8].…”

Section: Discussionmentioning

confidence: 99%

Endometrial lesion’s pattern in different age groups

Chernukha¹,

Asaturova²,

Ivanov³

et al. 2018

Akusherstvo i ginekologiia

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Background. Endometrial polyps (EP) take an important part in the structure of intrauterine pathology and could be associated with abnormal uterine bleeding (AUB), infertility and the risk of endometrial cancer (EC) development. The data concerning EP's prevalence and combination with other endometrium pathology's forms in women of different age varies widely. It causes difficulties for understanding the magnitude of the problem and finding solutions for management. Aim. To evaluate the prevalence of EP and other endometrium conditions at different ages. Materials and methods. Based on the study of 4059 histological samples we analysed the EP's prevalence and association with other intrauterine pathology in women of different age groups. Results. EP was diagnosed in 27.4% of samples. It's frequency varied from 21.7 to 27.3% in reproductive age and-45% in postmenopausal women. 19.8% of EP were concomitant with chronic endometritis (CE), 3.7% with endometrial hyperplasia (EH). Conclusions. EP take 1st place in the structure of intrauterine pathology during all age periods. Their prevalence is 2.7 times higher than CE, and 4.5 times higher than EH.

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Section: Discussionmentioning

confidence: 99%

Endometrial lesion’s pattern in different age groups

Chernukha¹,

Asaturova²,

Ivanov³

et al. 2018

Akusherstvo i ginekologiia

View full text Add to dashboard Cite

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“…Although diabetes does not seem to be directly linked to cervical polyps in our study; according to Topcu et al, menopause and DM are strong risk factors for the presence of concomitant endometrial polyps and endometrial hyperplasia. 24 Published studies focusing on the relationship between DM and polyp are only in endometrial polyps. There are reports of significant correlation between DM and endometrial polyps and there are also reports of no correlation.…”

Section: Discussionmentioning

confidence: 99%

“…There are reports of significant correlation between DM and endometrial polyps and there are also reports of no correlation. 8,24,25 To date few studies have investigated cervical polyps and their pathogenesis in detail.…”

Section: Discussionmentioning

confidence: 99%

Are Obesity, Diabetes, and Hypertension Risk Factors for Cervical Polyps?

Uçar¹,

Uçar²,

İlhan³

et al. 2016

Turkiye Klinikleri J Gynecol Obst

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226ervical polyps are common benign neoplasms of the cervix in adult women.1 They are believed to develop as a result of focal hyperplasia. They usually develop in multiparous women during the fifth Are Obesity, Diabetes, and Hypertension Risk Factors for Cervical Polyps?A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate whether diabetes, hypertension, and obesity can be considered risk factors for cervical polyps. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The hospital-based case-control study was carried out. We retrospectively reviewed the records of 307 consecutive patients with cervical polyps. A control group consisting of 3 women per case-matched by the same age, same parity, same menopausal status and the same presenting symptoms. These groups were compared with respect of diabetes, hypertension and obesity prevalence. R Re es su ul lt ts s: : The study included a total of 212 patients eligible for analysis in cervical polyp group, and a matched control group consisting of 636 women without cervical polyp. Women with cervical polyp had higher body mass index than the controls, but the difference was not statistically significant (p=0.72). The prevalence of obesity was significantly higher in the cervical polyp group than the controls (p=0.016). A statistically significant correlation was found between obesity and cervical polyps (OR: 1.351, CI: 1.062-1,718). There was no significant difference between the groups with respect to the prevalence of diabetes (p=0.795) and hypertension (p=0.703). C Co on nc cl lu us si io on n: : Obesity appears to be a risk factor for cervical polyps. Obese women should receive special attention for potential coexistence of cervical polyps as part of their gynecological evaluation. This study supports the importance of weight management for the preventive plan of cervical polyps.K Ke ey y W Wo or rd ds s: : Cervix uteri; polyps; diabetes mellitus; hypertension; obesity Ö ÖZ ZE ET T A Am ma aç ç: : Diyabet, hipertansiyon ve obezitenin servikal polipler için risk faktörü olup olmadığını araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hastane tabanlı vaka-kontrol çalışması oluşturuldu. 307 ardışık servikal polip hastasının kayıtları retrospektif olarak değerlendirildi. Her servikal polip hastası için, aynı yaş, aynı parite, aynı menopozal durumda ve aynı başvuru şikayeti ile gelen 3 kontrol hastası belirlendi. Gruplar hipertansiyon, diyabet ve obezite prevalansı açısından karşılaştırıldı. B Bu ul lg gu ul la ar r: : Çalışma kriterlerine uygun servikal polibi olan 212 hasta vaka grubuna ve servikal polibi olmayan eşleştirilmiş 636 hasta kontrol grubuna dahil edildi. Servikal polip hastalarının beden kitle indeksi, kontrol grubundan daha fazlaydı, ancak bu fark istatistiksel anlamlı değildi (p=0,72). Obezite prevalansı servikal polip grubunda, kontrol grubundan istatistiksel olarak anlamlı düzeyde yüksek bulundu (p=0,016). Obezite ve servikal polipler arasında istatistiksel anlamlı düzeyde korelasyon saptandı (OR: 1,351, ...

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“…Ймовірні механізми впливу гіперінсулінемії на розвиток гіперпластичних процесів полягають у здатності інсуліну зв'язуватися в ендометрії з рецепторами інсуліноподібного й ендотеліального факторів росту. Це призводить до зростання клітинної проліферації, неоангіогенезу, а також інгібування апоптозу в ендометрії [7,26]. Гіперінсулінемія підвищує експресію естрогенових рецепторів в ендометрії і сприяє позагонадному синтезу естрогенів у жировій тканині, що також сприяє розвитку гіперпластичних процесів в ендометрії [7,16,19,22,26].…”

Section: обговорення результатів дослідженняunclassified

“…Важливим у прогнозуванні ймовірності виникнення ГЗЕ в постменопаузі є чітке розуміння причинних факторів, що сприяють патологічній проліферації ендометрія в періоді фізіологічного спаду гормональної активності. Можливими епігенетичними чинниками є вплив певних ендокринно-обмінних порушень і соматичних захворювань, частота яких зростає з віком [7,16,24,26,27]. Тому визначення рівня екстрагенітальної захворюваності, виявлення порушень гормонального гомеостазу в жінок із ГЗЕ в постменопаузі може бути важливою складовою в розробці оптимальних лікувально-профілактичних заходів у даної категорії жінок.…”

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