Risk factors for epilepsy after ischemic stroke in children

Abstract

Objective: We performed this study to determine the incidence of seizures and poststroke epilepsy and risk factors of post-stroke epilepsy after childhood ischemic stroke. Methods: In this study, we retrospectively analyzed data from children who had ischemic stroke. Results: Of the one hundred and two children, mean age of stroke onset was 67.32± 25.48 months (1-180 months). There were 56 (54.9%) boys and 46 (45.1%) girls in the study . Of the 102 patients, 39 (38.2%) had seizures. Twenty seven (69.2%) had earlyonset post-stroke seizures, and 12 (30.8%) had late-onset post-stroke seizures. Epilepsy were detected in 17 (16.7%) of the patients. Eight of them had early-onset and nine had late-onset post-stroke seizures. We found that cortical involvement and late onset post-stroke seizure are predictors of the development of post-stroke epilepsy. Conclusions: Post-stroke seizures and epilepsy in children are common. Therefore, further studies are needed to describe risk factors for the development of post-stroke epilepsy in this population. Keywords:Ischemic stroke, post-stroke epilepsy, risk factors, children ÖZ Amaç: Bu çalışma, çocukluk çağı iskemik inme sonrasında nöbet, epilepsi ve epilepsi insidansı ile risk faktörlerinin saptanması için yapıldı. Yöntem: Çalışmada, iskemik inme geçiren çocukların verileri retrospektif olarak analiz edildi. Bulgular: İskemik inme geçiren 102 hastanın yaş ortalaması 67,32± 25,48 ay (1-180 ay) idi. Elli altısı (%54,9) erkek ve 46'sı ise (%45,1) kız idi. Yüz iki hastanın, 39'u (%38,2) nöbet geçirmişti. Yirmi yedi (%69,2) hastanın nöbeti erken başlangıçlı iken, 12 (%30,8) hastanın nöbeti geç başlangıçlıydı. Hastaların 17'sinde (%16,7) epilepsi gelişmişti. Bunların 8'i erken başlangıçlı nöbeti olan hastayken, 9'u ise geç başlangıç-lı nöbeti olan hastalardı. Lezyonun lokalizasyonu ve nöbet başlama zamanı epilepsi için risk faktörü saptandı. Sonuç: İnme sonrası nöbetler ve epilepsi çocuklarda sık görülür. Bu nedenle, bu populasyonda, inme sonrası epilepsi gelişme riskini saptamak için daha fazla çalışma-ya gereksinim vardır.

Does the Occurrence of Particular Symptoms and Outcomes of Arterial Ischemic Stroke Depend on Sex in Pediatric Patients?—A Pilot Study

“…Seizures after stroke appeared significantly more commonly in girls with TACI stroke, while only in one girl with LACI stroke and in the only girl with POCI stroke ( p = 0.022). A study performed in Turkey also demonstrated that post-stroke epilepsy was more common in AIS girls, whereas no significant sex differences were observed between AIS children with epilepsy and AIS children without epilepsy [ 33 ]. In the study by Laugesaar et al [ 34 ], cortical lesions, and involvement of the thalamus and temporal lobe, were reported to be independent predictors of post-stroke epilepsy in 73 children, of whom 53% were boys.…”