Risk Factors for Epithelial Ovarian Carcinoma in India: A Case Control Study in Low-Incidence Population

Shanmughapriya, Santhanam; Senthilkumar, G.; Seshachalam, Arun; Das, B. C.; Natarajaseenivasan, Kalimuthusamy

doi:10.3923/ijcr.2016.61.68

Cited by 9 publications

(18 citation statements)

References 25 publications

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“…Most previous reports were limited to cases in Western countries and the USA. Studies have reported that the annual incidence of ovarian cancer varies with race [ 8 , 40 , 41 ]. The genetic background and heredity of patients may be associated with different frequencies of histological subtypes and FIGO stage and thus influence prognosis.…”

Section: Discussionmentioning

confidence: 99%

Age is associated with prognosis in serous ovarian carcinoma

Deng

et al. 2017

J Ovarian Res

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PurposeThe survival duration of elderly patients with epithelial ovarian carcinoma is shorter than that of their younger counterparts. This variation in survival duration is likely attributed to differences in the distribution of histological type or grade, International Federation of Gynecology and Obstetrics (FIGO) staging, and undertreatment, but this observation remains controversial. This study aimed to investigate the biological factors other than selection bias associated with the decreased survival of elderly patients with ovarian carcinoma.MethodsA total of 314 serous ovarian cancer (SOC) patients from Jiangsu Institute of Cancer Research (JICR, PRC) between 2002 and 2012 were retrospectively analyzed, and 774 cases from MD Anderson Cancer Center (MDACC, USA) between 1992 and 2012 were used for validation. The 8-hydroxy-2′-deoxyguanine (8-OHdG) concentration in leukocyte DNA was evaluated by using commercially available enzyme-linked immunosorbent assay kits, and tissue expression was assayed through immunohistochemistry. The associations between survival durations and covariates were assessed by using a Cox proportional hazards model and by conducting a log-rank test.ResultsAdvanced age ≥ 65 years was correlated with high histological grade (p = 0.02), performance status (p = 0.03), primary treatment (p = 0.00), and suboptimal surgery outcome (p = 0.04) in SOC patients from JICR. Age, FIGO stage, histological grade, and optimal surgery were independently associated with the progression-free survival (PFS; p = 0.03, p = 0.03, p = 0.02, and p = 0.04, respectively) and overall survival (OS; p = 0.02, p = 0.04, p = 0.02, and p = 0.02, respectively) of the SOC patients from JICR. The 8-OHdG concentration in the leukocyte DNA was higher in the elderly patients than in the younger cases. The high 8-OHdG concentration in the leukocyte DNA indicated poorer median OS (30.0 months, confidence interval [CI]: 23.5–36.5 vs. 42.8 months, [CI] 38.3–47.2) and PFS (14.6 months, [CI] 11.9–17.2 vs. 18.9 months, [CI] 14.4–23.4) than those of their corresponding counterparts in the SOC patients who achieved a clinical complete response from primary treatment.ConclusionsCompared with younger cases, elderly patients with SOC were commonly characterized by high tumor grade, poor performance status, and undertreatment. High 8-OHdG concentration in leukocyte DNA was associated with advanced age and poor prognosis in SOC patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13048-017-0331-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Age is associated with prognosis in serous ovarian carcinoma

Deng

et al. 2017

J Ovarian Res

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“…Many studies support this postulation, such as [26][27][28] The study also indicated that with each year's use of oral contraceptive pills by 7% 26 . The length of use of oral contraceptives is also an essential factor, and The reduced risk can continue for up to 10-15 years after the cessation of pills 27,29 .…”

Section: H5: Ovulation Information Has a Positive Association With The Risk Of Developing Ovarian Cancer In Women In Libyamentioning

confidence: 79%

“…The findings of the study are similar to findings discussed in the literature. such as [26][27][28] .…”

Section: Use Of Hormonal Birth Control As Risk Factor For Ovarian Cancermentioning

confidence: 99%

Risk Factors for Ovarian Cancer among Libyan Women

Almisawi¹,

Albajalan²

2021

IJPHRD

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Ovarian cancer is the third type of gynecologic cancer in terms of prevalence after cervical and uterine cancer. The disease is known as the silent killer as it is slowly spread without a diagnosis, which leads to the worst prognosis and high mortality rate. Libya shows low disease incidence while the high mortality rate is seen in developed countries due to a lack of proper diagnostic and treatment options. This research aims to understand the various risk factors of ovarian cancer among the women in Libya. A questionnaire is used in a quantitative research methodology using stratified random sample over the population is divided in two classes namely healthy and diseased, based on earlier diagnosis and ovarian cancer care. The diseased and healthy women were targeted in a written survey in different hospitals and clinics in Libya. The data analysis is done in four stages. The first stage is cleaning and coding of the data. The second step is the demographic profile of the respondents. The third stage. Frequency distribution of the data in order to compare the healthy and diseased women. The fourth stage is the linear logistic regression in order to determine the risk factors for ovarian cancer and test the research hypotheses. The logistic regression analysis indicated good fit of the model. The model was able to correctly predicted 81.4 % of the cases which is 19.6 % increase over the null model. The logistic regression analysis was also used to indicate the predictors namely family history, level of obesity, ovulation information, use of birth control and breast feeding unlike awareness, nature of diet which was not predictor in the model.

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“…The incidence of ovarian tumours in modern Chennai is around 6.1 per 100 000 females. 2 The 5-year survival rate for ovarian malignancy is 30-40% as they are mostly inoperable at the time of diagnosis. 8 Ovarian tumours may be benign, malignant or borderline malignant.…”

Section: Discussionmentioning

confidence: 99%

A case series on large benign ovarian tumours in post-menopausal woman

2020

IJOGR

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Introduction: Space occupying large abdomino -pelvic ovarian tumours are uncommon. Such huge ovarian tumours in postmenopausal women have to be evaluated as they raise the suspicion of malignancy. The prevalence of ovarian neoplasm in postmenopausal women is 14-18% with a risk of 10-40% in the case of large complex ovarian cysts. Objective: To study the clinical features, imaging and management of 5 post-menopausal women with large benign ovarian tumours. Materials and Methods: A retrospective study in a tertiary care institutional hospital between December 2017-February 2018 among 5 post-menopausal women with large benign ovarian tumours. Results: All of them presented with abdominal distension, abdominal pain and breathing difficulties. They underwent exploratory laparotomy with frozen section. Histopathology reports of all 5 showed benign ovarian tumours, the most common being serous cystadenoma. Conclusion:The large size of the ovarian tumour warrants surgical removal of the same. This case series shows that not all extremely large tumours need to be malignant. Patients also present at a much later stage due to lack of awareness, ignorance and logistic reasons.

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Risk Factors for Epithelial Ovarian Carcinoma in India: A Case Control Study in Low-Incidence Population

Cited by 9 publications

References 25 publications

Age is associated with prognosis in serous ovarian carcinoma

Age is associated with prognosis in serous ovarian carcinoma

Risk Factors for Ovarian Cancer among Libyan Women

A case series on large benign ovarian tumours in post-menopausal woman

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