Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males

Gunji, Toshiaki; Sato, Hajime; Iijima, Kimiko; Fujibayashi, Kazutoshi; Okumura, Mitsue; Sasabe, Noriko; Urabe, Akio; Matsuhashi, Nobuyuki

doi:10.1007/s00535-010-0359-5

Cited by 67 publications

(52 citation statements)

References 40 publications

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“…While there have been many reports on the relationship between obesity and GERD (16)(17)(18)(19)(20)(21)(22)(23)(24), other studies contradict such a connection (25,26). Our recent cross-sectional study involving 9,840 Japanese asymptomatic males demonstrated central obesity, as determined by waist girth and visceral adipose tissue, did not increase the risk for endoscopic erosive esophagitis (27). In addition, studies of Asian populations have identified several risk factors for GERD, including age, male sex, race, family history, higher socioeconomic status, increased body mass index (BMI), and smoking (28).…”

Section: Introductionmentioning

confidence: 80%

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A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

et al. 2012

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Objective To investigate the impact of metabolic and lifestyle factors on erosive esophagitis in young adults. Methods A total of 5,069 people under the age of 40 years old were enrolled in a medical survey at our institute. People with a previous history of upper gastrointestinal tract surgery were excluded, as were individuals taking medication for reflux symptoms, peptic ulcers, or malignancies. Independent and significant predictors affecting the presence of erosive esophagitis were determined by multivariate analysis. Results A total of 4,990 participants (male/female; 3,871/1,119, age; 33.9±3.9 years) were eligible. A total of 728 participants (14.6%) had erosive esophagitis. Male gender and increasing age were independent predictors for increased prevalence of erosive esophagitis (odds ratio=2.242 and 1.045. 95% confidence interval= 1.613-3.117 and 1.019-1.072; p<0.001 and 0.001, respectively). Moderate-to-heavy alcohol consumption, light-to-moderate-to-heavy smoking, hypertension, hyperglycemia, and hiatal hernia each significantly and independently increased the risk for erosive esophagitis (odds ratio=1.499, 1.398, 1.353, 1.570, 1.884, 1.297, 1.562, and 3.213. 95% confidence interval=1.181-1.903, 1.040-1.880, 1.094-1.675, 1.250-1.971, 1.307-2.716, 1.074-1.566, 1.063-2.295, and 2.712-3.807; p=0.001, 0.027, 0.005, <0.001, 0.001, <0.001, 0.007, 0.023, and <0.001 respectively). Helicobacter pylori infection decreased the risk for erosive esophagitis (odds ratio= 0.575, 95% confidence interval =0.436-0.759 p<0.001). Neither body mass index nor waist girth conferred increased risk of erosive esophagitis after adjusting for potential confounding factors. Conclusion Risk of erosive esophagitis in Japanese young adults was not increased by obesity, but it was increased by hiatal hernia and metabolic and lifestyle profiles including hypertension, hyperglycemia, alcohol consumption and smoking.

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Section: Introductionmentioning

confidence: 80%

“…In this connection, this study's subjects included Japanese males and females under age 40 years old, and therefore they were not a subgroup of the previous our report involving asymptomatic males of all ages (27). Most participants were professional workers in higher socioeconomic category from around the Tokyo metropolitan area.…”

Section: Study Populationmentioning

confidence: 99%

A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

et al. 2012

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“…Because esophagitis and esophageal ulcer were such common causes of bleeding and rebleeding in AAs in this study, the effects of alcohol on the esophagus are worth further discussion. Although there is no indisputable evidence that either acute or chronic alcohol consumption increases the risk of peptic ulcer disease, excessive drinking of alcoholic beverages causes erosive esophagitis [10,20]. Alcohol decreases the lower esophageal sphincter tone and inhibits peristalsis of the esophagus, resulting in an increase and prolongation of gastroesophageal reflux [10].…”

Section: Discussionmentioning

confidence: 99%

Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding

et al. 2015

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“…In this regard, correlations between reflux esophagitis and obesity in the Japanese population have also been somewhat conflicting [15,16,17,18], although a positive association has been observed in previous studies [15,16,17]. Meanwhile, the vast majority of subjects in these studies have had short-segment BE, and in particular ultra-short (<1 cm)-segment BE has been present in a substantial number of BE subjects in these studies [10,14,19].…”

Section: Introductionmentioning

confidence: 99%

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

Shinkai

Iijima²,

Koike³

et al. 2014

Digestion

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Background: We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. Methods: One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI <22.9; overweight, BMI 23.0-24.9, and obese, BMI >25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. Results: The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. Conclusions: An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.

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Risk factors for erosive esophagitis: a cross-sectional study of a large number of Japanese males

Abstract: Lifestyle factors including heavy alcohol consumption, heavy smoking, metabolic disorders, and hiatal hernia increased the risk of erosive esophagitis, but central obesity did not.

Cited by 67 publications

References 40 publications

A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding

Association between the Body Mass Index and the Risk of Barrett's Esophagus in Japan

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