Risk factors for fluctuations in corneal endothelial cell density (Review)

Vaičiulienė, Renata; Rylskyte, Neda; Baguzyte, Gabija; Jašinskas, Vytautas

doi:10.3892/etm.2021.11052

Cited by 28 publications

(20 citation statements)

References 84 publications

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“…In this study, effects of AGV implantation were comparable to effects of MTMT on ECD changes and graft survival in patients with penetrating keratoplasty for at least 12 months. However, surprisingly, the reduction in ECD with MTMT of PKP eyes for bullous keratopathy was greater than those eyes with normal ECD in previous studies ( 5 , 7 , 16 ). This is the first report to evaluate ECD changes with MTMT in corneal transplanted eyes so far.…”

Section: Discussioncontrasting

confidence: 69%

Clinical Outcomes in Maximum Tolerated Medical Therapy in Penetrating Keratoplasty for Bullous Keratopathy

Kim

Jeoung

et al. 2022

Front. Med.

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PurposeTo compare the clinical outcomes of maximum tolerated medical therapy (MTMT) in patients with penetrating keratoplasty (PKP) with those of Ahmed glaucoma valve (AGV) implantation.MethodsThe medical records were retrospectively reviewed in patients who had undergone PKP for bullous keratopathy and were treated with MTMT or AGV implantation for the management of glaucoma. A total of 18 bullous keratopathic patients were investigated between January 2010 and February 2017: 9 patients treated with MTMT and 9 patients treated with AGV implantation. Non-corrected visual acuity (NCVA), intraocular pressure (IOP), endothelial cell density (ECD), hexagonality, coefficient of variation (CV), central corneal thickness (CCT), median survival time of the graft, and the presence of epithelial keratopathy were compared between the groups at each time point or between baseline and after treatment of glaucoma in each group.ResultsThere were no significant differences in the visual acuity and corneal thickness between the two groups or within each group over time. Both groups showed a significant reduction in IOP compared with the baseline IOP, and IOP reductions were greater in the AGV group than in the MTMT group (p = 0.040). Significant ECD reductions were found in each group between the baseline and 6 months (p = 0.008 in the MTMT group, p = 0.015 in the AGV group); however, no differences were found between the two groups until 12 months. The significant hexagonality reduction was found in the AGV group between the baseline and 12 months (p = 0.018). The median survival time showed no significant difference in the survival analysis.ConclusionsMaximum tolerated medical therapy in penetrating keratoplasty for bullous keratopathy seems to similarly affect the endothelial cell density or graft survival when compared with at least 12 month-followed Ahmed glaucoma valve implantation.

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Section: Discussioncontrasting

confidence: 69%

Clinical Outcomes in Maximum Tolerated Medical Therapy in Penetrating Keratoplasty for Bullous Keratopathy

Kim

Jeoung

et al. 2022

Front. Med.

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“…[ 10 ] MSICS is also associated with endothelial cell loss, and the reported incidence is 4%–17% in various studies. [ 11 ] Less viscoelastic cover to the endothelium, nucleus prolapse, nucleus delivery, and continued jet of irrigation and aspiration are the significant factors causing endothelial cell loss during MSICS. [ 11 ] Nayak and Jain,[ 12 ] in their analysis, compared the endothelial cell loss during phacoemulsification using continuous anterior chamber (AC) infusion versus the endothelial cell loss on using an ophthalmic viscosurgical device and found that there is not much difference in endothelial cell loss during the two techniques.…”

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confidence: 99%

Comparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trial

Morya

Gurnani

Mishra

et al. 2022

Indian Journal of Ophthalmology

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Purpose: The purpose of this study was to compare and analyze the endothelial cell loss during manual small-incision cataract surgery (MSICS) using the viscoelastic-assisted nucleus removal versus basal salt solution plus technique. Methods: This was a prospective randomized trial of 204 patients who underwent MSICS using viscoelastic-assisted nucleus removal (Group 1- OVD) versus basal salt solution plus technique (Group 2- BSS) at a tertiary eye care hospital in North India from January 2018 to 2021. Of these 204 patients, 103 (50.5%) and 101 (49.5%) were allocated to Group 1 and 2, respectively. The parameters assessed were detailed history, demographics, and anterior and posterior segment details. Visual acuity, intraocular pressure (IOP), keratometry, pachymetry, and endothelial cell density were evaluated preoperatively and postoperatively on day 1 and 30. Results: The mean age of the patients was 64.5 ± 8.2 years (range 48–82 years). There were 129 (63.2%) males and 75 (36.8%) females. The mean LogMAR visual acuity for both groups on day 1 (Group 1- 0.3 ± 0.1, Group 2- 0.5 ± 0.2) and day 30 (Group 1- 0.1 ± 0.2, Group 2- 0.1 ± 0.1) was statistically significant ( P < 0.001), and the mean IO P value showed a statistically significant value ( P < 0.009) on day 1 in Group 2 (15.0 ± 2.4 mmHg) and on day 30 ( P < 0.001) in both the groups (Group 1- 13.6 ± 1.8 mmHg, Group 2- 13.5 ± 2 mmHg). The horizontal and vertical k values also showed a statistically significant difference on day 1 and day 30 ( P < 0.001). The mean percentage change of central corneal thickness (CCT) in Group 1 was 17.7% and in Group 2 was 17.4% on day 1, and it was 1.1% on day 30 in both the groups, which was statistically significant ( P < 0.001) compared to preoperative values. The percentage change in endothelial cell density on day 1 was 9% in Group 1 and 4.6% in Group 2, which was statistically significant ( P < 0.001). On day 30, it was 9.7% and 4.8%, respectively, which was statistically significant ( P < 0.001). Conclusion: Our study highlights statistically significant endothelial cell loss with viscoelastic-assisted nuclear delivery compared to BSS-assisted nuclear delivery during MSICS in a short follow-up of 1 month. The CCT values showed a slight increase, and the keratometry and IOP were unaffected compared to the preoperative parameters in both the groups.

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“…A flat anterior chamber usually associated with hypotony could also cause a shorter tube-endothelium distance and an augmented endothelial corneal loss [33]. Reducing the risk of postoperative hypotony could reduce the risk of corneal decompensation and a decrease in VA [34].…”

Section: Studiesmentioning

confidence: 99%

PRESERFLO MicroShunt in Severe Myopia: A Case Report and Review of the Literature

George,

Abouzeid

2024

Klin Monbl Augenheilkd

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The PRESERFLO™ MicroShunt (MP; Santen Inc., Osaka, Japan) is a minimally invasive bleb surgery (MIBS) manufactured to treat primary open-angle glaucoma (POAG), with lower postoperative adverse effects than with conventional filtering surgeries. We describe here the case study of a 58-year-old woman who presented with bilateral severe myopia with bilateral advanced POAG and unreached target pressure under quadritherapy, who was successfully managed by PM surgery. A review of the literature completes our observation. At presentation, the patient had a spherical equivalent of − 7.50 RE and − 7.75 LE with an IOP of 22 mmHg right and left eye (RLE) under quadritherapy, and with severe bilateral visual field loss, including scotomas within the central 5°. The patient presented with systemic hypertension treated with an antihypertensive drug. Two selective laser trabeculoplasties (SLT), performed 3 months apart, were first tried on the LE, without any change in IOP at 2 months. After considering the high risk of postoperative complications, a PM operation was proposed, with a targeted IOP in the mid-fifteens RLE. The patientʼs eyes underwent PM surgery with mitomycin C (MMC) MMC0.2 mg/mL for 3 minutes without any complications. The LE required 2 consecutive needlings with 1 mL MMC0.2 mg/mL. At 24 months after surgery, the two eyes gave successful results without the need for any additional medical therapy, and with well-functioning conjunctival blebs. The PM was an effective alternative to the gold standard trabeculectomy in our severely myopic patient. A comparative study between conventional filtering operations and this MIBS in highly myopic patients would confirm our observation.

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Risk factors for fluctuations in corneal endothelial cell density (Review)

Cited by 28 publications

References 84 publications

Clinical Outcomes in Maximum Tolerated Medical Therapy in Penetrating Keratoplasty for Bullous Keratopathy

Clinical Outcomes in Maximum Tolerated Medical Therapy in Penetrating Keratoplasty for Bullous Keratopathy

Comparison of corneal endothelial cell loss during manual small-incision cataract surgery using viscoelastic-assisted nucleus removal versus continuous balanced salt solution plus technique - Randomized controlled trial

PRESERFLO MicroShunt in Severe Myopia: A Case Report and Review of the Literature

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