Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

Higashizono, Kazuya; Nakatani, Eiji; Hawke, Philip; Fujimoto, Shuhei; Oba, Noriyuki

doi:10.1371/journal.pone.0274659

Cited by 13 publications

(6 citation statements)

References 37 publications

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“…Obesity serves as a predisposing factor for gallstone formation, while estrogen enhances the risk by promoting hepatic cholesterol synthesis and secretion while inhibiting bile salt synthesis. Furthermore, high blood pressure, insulin resistance, and diabetes independently contribute to gallstone development (1,(33)(34)(35)(36)(37). These factors likely explain the association between elevated blood cobalt levels and an increased risk of gallstones among women, obese individuals, and patients with hypertension or diabetes.…”

Section: Discussionmentioning

confidence: 99%

Investigating the association between blood cobalt and gallstones: a cross-sectional study utilizing NHANES data

Li,

Han,

You

et al. 2024

Front. Public Health

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BackgroundWith the use of cobalt alloys in medical prosthetics, the risk of cobalt exposure has increased. The objective of this study was to investigate the correlation between blood cobalt levels and the occurrence of gallstones utilizing data from the National Health and Nutrition Examination Survey (NHANES).MethodsData collected between 2017 and 2020 were analyzed, encompassing a total of 5,610 participants. Cobalt concentrations in whole blood specimens were directly measured using inductively coupled plasma mass spectrometry (ICP-MS). The presence of gallstones was ascertained through a standardized questionnaire. To assess the association between blood cobalt levels and the presence of gallstones, logistic regression analysis, restricted cubic spline analysis, and subgroup analysis were utilized.ResultsThe results of logistic regression analysis revealed a heightened risk of developing gallstones in the Quartiles 2 and Quartiles 4 groups based on blood cobalt levels when compared to the Quartiles 1 group (OR = 1.54, 95% CI: 1.15–2.07; OR = 1.35, 95% CI: 1.03–1.77). The restricted cubic spline analysis exhibited a positive linear correlation between blood cobalt levels and the occurrence of gallstones. Subgroup analyses further demonstrated a statistically significant correlation between the Quartiles 4 category of blood cobalt levels and an elevated risk of gallstones, particularly among individuals aged 60 years or older, females, those with a body mass index (BMI) equal to or exceeding 25, serum total cholesterol levels below 200 mg/dL, as well as individuals diagnosed with hypertension or diabetes.ConclusionOur study findings indicate a notable association between elevated blood cobalt levels and an increased risk of gallstones. To establish a causal relationship between blood cobalt levels and the elevated risk of developing gallstones, further prospective cohort studies are warranted.

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Section: Discussionmentioning

confidence: 99%

Investigating the association between blood cobalt and gallstones: a cross-sectional study utilizing NHANES data

Li,

Han,

You

et al. 2024

Front. Public Health

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“…The prevalence of cholelithiasis in our cohort of SPIMD is 27%, which surpassed that of 4–10% found in Japanese cohorts without SPIMD (Higashizono et al . 2022). The incidence of acute cholecystitis or cholangitis in patients with SPIMD accompanied by cholelithiasis is 25%, which is significantly higher than the general incidence of cholelithiasis in patients with acute cholecystitis or cholangitis (1–2%) (Lammert et al .…”

Section: Discussionmentioning

confidence: 99%

“…The estimated prevalence of cholelithiasis varies geographically and with populations. For example, the prevalence of gallstones is 14-20% in Europe and the USA but lower in East Asia, particularly in Japan, where it is 4-10% (Ferkingstad et al 2018;Higashizono et al 2022;Unalp-Arida et al 2023).…”

Section: Introductionmentioning

confidence: 99%

Cholelithiasis prevalence and risk factors in individuals with severe or profound intellectual and motor disabilities

Watanabe,

Tomioka,

Okata

et al. 2024

J intellect Disabil Res

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BackgroundThe prevalence and risk factors of cholelithiasis in individuals with severe or profound intellectual and motor disabilities (SPIMD) are poorly characterised. Thus, we aimed to investigate the prevalence and risk determinants of cholelithiasis in a cohort with SPIMD under medical care in a residential facility.MethodsWe categorised 84 patients in a residential hospital for persons with SPIMD into groups: those with (Group CL) and without (Group N) cholelithiasis. Gallstones were detected via computed tomography, ultrasonography or both. We evaluated gastrostomy status, nutritional and respiratory support, constipation, and bladder and kidney stones. Data were significantly analysed using univariate and multivariate logistic regression analyses.ResultsThe prevalence rate of cholelithiasis in our SPIMD cohort was 27%. There were no significant differences in sex, age, weight, height, or Gross Motor Function Classification System between the two groups. However, more patients received enteral nutrition (39.13% vs. 6.56%; P = 0.000751) and were on ventilator support (56.52% vs. 19.67%; P = 0.00249) in Group CL than in Group N. Enteral nutrition [odds ratio (OR) 10.4, 95% confidence interval (CI) 1.98–54.7] and ventilator support (OR 20.0, 95% CI 1.99–201.0) were identified as independent risk factors for the prevalence of cholelithiasis in patients with SPIMD.ConclusionsPatients with SPIMD demonstrated an increased prevalence of cholelithiasis, with a notable association between nutritional tonic use and respiratory support. Therefore, to emphasise the need for proactive screening, it is crucial to devise diagnostic and therapeutic strategies specific to patients with SPIMD. Further investigation is essential to validate our findings and explore causative factors.

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“…The SKDB includes information on a regional population-based longitudinal cohort of 2 398 393 Japanese individuals (women, n = 1 303 667, 54.4%) living in Shizuoka Prefecture (population: approximately 3.6 million) 10 and has been used as a data source for several studies. [11][12][13] Comprehensive personally linked…”

Section: Setting and Data Sourcementioning

confidence: 99%

Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho database: The Shizuoka study

Imaichi,

Nakatani,

Fukutomi

et al. 2023

Epilepsia Open

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ObjectiveManaging the risk of epileptic seizures in older adults is increasingly important as the population ages. Leukotriene receptor antagonists (LTRAs) are commonly used to treat asthma or allergic rhinitis. Preclinical studies suggest that LTRAs have antiepileptic effects; however, few population‐based etiological studies on this topic have been available. Our study explored whether LTRAs reduce hospitalization risk associated with epileptic seizure in older individuals with asthma or allergic rhinitis.MethodsWe conducted a new‐user design analysis using the Shizuoka Kokuho database. We included all individuals aged 60–89 years who had at least one episode of allergic rhinitis or asthma during the study period. We compared individuals who newly started LTRAs with those who did not take LTRAs. Propensity score matching was used to balance the baseline characteristics of the participants. We compared the hazard ratios for seizure‐related hospitalization between new LTRA users and non‐users and performed subgroup analyses.ResultsOur matched cohorts consisted of 64,724 new users and non‐users of LTRAs who were aged 60–89 years and had asthma or allergic rhinitis. During the observation period, 377 (0.58%) and 595 (0.92%) incidents were observed in the LTRA new‐user and non‐user groups, respectively. The hazard ratio for seizure‐related hospitalization was 0.75 (95% confidence interval [CI]: 0.62–0.92) in the LTRA new‐user group compared with the non‐user group. Subgroup analysis revealed that the hazard ratio was weak in diabetic patients (1.31; 95% CI: 0.72–2.38).SignificanceThis study indicated that LTRAs reduced seizure‐related hospitalization in older adult patients with allergic rhinitis or asthma. We could not evaluate the severity and related diseases of epileptic seizure during LTRAs. Further studies, including observational studies, detailed multicenter prospective studies, and clinical trials, are needed to validate these findings.

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Risk factors for gallstone disease onset in Japan: Findings from the Shizuoka Study, a population-based cohort study

Cited by 13 publications

References 37 publications

Investigating the association between blood cobalt and gallstones: a cross-sectional study utilizing NHANES data

Investigating the association between blood cobalt and gallstones: a cross-sectional study utilizing NHANES data

Cholelithiasis prevalence and risk factors in individuals with severe or profound intellectual and motor disabilities

Leukotriene antagonists reduce epileptic seizures‐related hospitalization in older adult populations with allergic rhinitis or asthma: A population‐based cohort study using the Shizuoka Kokuho database: The Shizuoka study

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