Risk Factors for Glaucoma Drainage Device Revision or Removal Using the IRIS Registry

Hall, Nathan; Chang, Enchi K.; Samuel, Sandy; Gupta, Shivani; Klug, Emma; Elze, Tobias; Lorch, Alice C.; Miller, Joan W.; Valle, David Solá-Del

doi:10.1016/j.ajo.2022.03.029

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…In contrast to prior studies, they found Caucasian race to have a higher risk of experiencing a sooner second re‐exposure of GDD 100 . While in the retrospective cohort study of 44 330 patients by Hall et al, Black race was not associated with a higher risk of revision or removal of GDD in the multivariable models 101 …”

Section: Discussioncontrasting

confidence: 57%

“…100 While in the retrospective cohort study of 44 330 patients by Hall et al, Black race was not associated with a higher risk of revision or removal of GDD in the multivariable models. 101 Although less attended to, sociodemographic disparities are also present in glaucoma clinical trials access and representation. The cross-sectional study by Soares et al reported worse access to ophthalmology clinical trial sites for patients living in rural areas or of lower income and education level.…”

Section: Access To Surgery and Surgical Outcomesmentioning

confidence: 99%

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Social determinants of health and health disparities in glaucoma: A review

Acuff,

Wu,

Varkhedi

et al. 2024

Clinical Exper Ophthalmology

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Social determinants of health and barriers to care can significantly impact patients' access to glaucoma care and treatment, resulting in disparities within disease presentation, progression, management, and treatment outcomes. The widespread adoption of electronic health record systems has allowed researchers and clinicians to further explore these relationships, identifying factors such as race, ethnicity, and socioeconomic status to be risk factors for more severe disease and lower treatment adherence. These disparities highlight potential targets for interventions to combat these disparities and improve overall patient outcomes. This article provides a summary of the available data on health disparities within glaucoma disease presentation, progression, management, treatment, and outcomes and discusses interventions to improve care delivery and outcomes among patients with glaucoma.

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Section: Discussioncontrasting

confidence: 57%

Section: Access To Surgery and Surgical Outcomesmentioning

confidence: 99%

Social determinants of health and health disparities in glaucoma: A review

Acuff,

Wu,

Varkhedi

et al. 2024

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“…This shows that the initial result was driven mainly by this study due to the larger weight it contributes to the overall metaanalysis. That being said, it should be recognized that many factors contribute to the risk of revision surgery following glaucoma management (i.e., dry eye disease, chronic glaucoma, previous eye procedures) 35 , and in our analysis, we are not certain that these factors were balanced across studied interventions to re ect a real increase in the risk of revision surgery in the CP/PCP group. Therefore, we recommend future studies to put these factors into consideration when designing their studies or analysis based on previously collected data (through propensity-score matching) to be able to reach more valid and reliable evidence.…”

Section: Pcp] Comparisonmentioning

confidence: 88%

The Efficacy and Safety of Canaloplasty Vs Trabeculectomy Either Standalone or Combined with Cataract Surgery: An Updated Meta-Analysis

Abdelaal

Serhan

Elmallahy³

et al. 2023

Preprint

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To compare the efficacy and safety between trabeculectomy (TE) and canaloplasty (CP) either as standalone or combined with phacoemulsification (PTE and PCP). Nine databases were searched for studies reporting efficacy and safety of TE/PTE and CP/PCP. Efficacy endpoints included postoperative intraocular pressure (IOP), complete, and qualified success, while safety endpoints included failure, revision surgery, and complications. STATA was used to pool the crude mean difference (MD) or log odds ratio (logOR) for continuous and categorical outcomes, respectively. Fourteen studies were included. TE/PTE was associated with lower IOP when compared to CP/PCP [MD=-2.55; 95%CI=-3.30: -1.80, I2 = 61.43%]. Similarly, TE/PTE was associated with significantly higher odds of complete [logOR = 1.20; 95%CI = 0.79:1.61, I2 = 7.41] and qualified success [logOR = 0.64; 95%CI = 0.16:1.13, I2 = 0%] when compared to CP/PCP, respectively. Although no significant differences in failure and revision surgery were noted between TE/PTE and CP/PCP, in the TE subgroup, a significant reduction in failure was observed as compared to CP [logOR=-0.82; 95%CI=-1.61: -0.04, I2 = 28.18%]. TE/PTE was associated with higher odds for hypotony and choroidal detachment and lower odds for Descemet’s membrane detachment and hyphema. TE/PTE has superiority over CP/PCP regarding IOP control and revision surgery rates. However, the certainty of these findings is low to very low.

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“…While the size of this database is a major asset, it does not include nonophthalmic data, visual field, optic disc photographs, or optical coherence tomography (OCT) data. IRIS has been used in many studies investigating real-world patterns and outcomes for glaucoma care, such as investigation on Microinvasive Glaucoma Surgery utilization, variation in practice between academic and nonacademic settings, and risk factors for drainage device revision or removal 3–6 . Currently, access to IRIS is limited to academic medical centers of the IRIS Registry Analytic Center Consortium; some research awards, for example, through the American Glaucoma Society, also enable access to the IRIS registry.…”

Section: Big Data/data Sciencementioning

confidence: 99%

Lessons From The Glaucoma Foundation Think Tank 2023: A Patient-Centric Approach to Glaucoma

Harris,

Verticchio Vercellin,

Weinreb

et al. 2023

Journal of Glaucoma

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Purpose: To summarize the main topics discussed during the 28th Annual Glaucoma Foundation Think Tank Meeting “A Patient-Centric Approach to Glaucoma” held in New York on June 9th and 10th 2023. Methods: The highlights of the sessions on BIG DATA, genetics, modifiable lifestyle risk factors, female sex hormones, and neuroprotection in the field of primary open-angle glaucoma (POAG) were summarized. Results: The researchers discussed the importance of BIG DATA repositories available at national and international levels for POAG research, including the United Kingdom Biobank. Combining genotyped large cohorts worldwide, facilitated by artificial intelligence (AI) and machine learning approaches, led to the milestone discovery of 312 genome-wide significant disease loci for POAG. While these loci could be combined into a polygenic risk score with clinical utility, Think Tank meeting participants also provided analytical epidemiological evidence that behavioral risk factors modify POAG polygenetic risk, citing specific examples related to caffeine and alcohol use. The impact of female sex hormones on POAG pathophysiology was discussed, as was neuroprotection and the potential use of AI to help mitigate specific challenges faced in clinical trials and speed approval of neuroprotective agents. Conclusion: The experts agreed on the importance of genetics in defining individual POAG risk and highlighted the additional crucial role of lifestyle, gender, blood pressure, and vascular risk factors. The main takeaways also included that BIG DATA repositories and AI are important combinatory tools to foster novel strategies to prevent and stabilize glaucoma and, in the future, recover vision loss from the disease.

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Risk Factors for Glaucoma Drainage Device Revision or Removal Using the IRIS Registry

Cited by 8 publications

References 48 publications

Social determinants of health and health disparities in glaucoma: A review

Social determinants of health and health disparities in glaucoma: A review

The Efficacy and Safety of Canaloplasty Vs Trabeculectomy Either Standalone or Combined with Cataract Surgery: An Updated Meta-Analysis

Lessons From The Glaucoma Foundation Think Tank 2023: A Patient-Centric Approach to Glaucoma

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