Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis

Abstract

Risk factors for development of ocular hypertension/glaucoma were increasing patient age and having a cataract at presentation with FHC.

Predictive Factors of Intraocular Pressure Level Evolution Over Time and Glaucoma Severity in Fuchs' Heterochromic Iridocyclitis

“…28 With regard to IOH/glaucoma, it has been suggested to occur in 15% to 59% of cases, consistent with our results. 9,20 Disease duration (i.e., time between onset of symptoms and diagnosis) was found to be positively associated with IOP values, suggesting that early diagnosis is of importance in the management of FHC.…”

“…Because of its mildly symptomatic nature and the possible atypical signs, diagnosis can be overlooked or delayed for years and even decades (Brancaleoni A, et al IOVS 2003;44:ARVO E-Abstract 2381), increasing the risk of developing sight-threatening complications. Toniolo et al 20 recently reported that 39% of FHC patients eventually develop intraocular hypertension (IOH) or glaucoma. 20 In this pathology, the severity of glaucoma resides in its poor responsiveness to maximal medical therapy but also to surgery.…”

“…Toniolo et al 20 recently reported that 39% of FHC patients eventually develop intraocular hypertension (IOH) or glaucoma. 20 In this pathology, the severity of glaucoma resides in its poor responsiveness to maximal medical therapy but also to surgery. 8,9,21 If follow-up is recommended for all FHC patients, there are still no evidence-based guidelines regarding what subpopulation is at higher risk of complications.…”

“…Toniolo and colleagues 20 suggested that age was a risk factor of glaucoma in FHC patients. Here, utilizing specific statistical analyses that take into account multiple variables and their simultaneous variation over time, we were not able to confirm this statement.…”

Uveitic Ocular Hypertension and Glaucoma

“…Optimal treatment, which can be complex and often includes both medical and surgical approaches, should be directed at the underlying cause(s) of OHT. Five original articles [14][15][16][17][18] 19 months -19 years) and the mean time from onset of uveitis to the diagnosis of uveitic glaucoma was 4.5 ± 4.9 years. A high proportion of affected eyes were exposed at some point to topical (73.6%), periocular (34.0%), and/or systemic (30.2%) corticosteroids.…”