Risk factors for hearing loss in infants under universal hearing screening program in Northern Thailand

Poonual, Watcharapol; Navacharoen, Niramon; Kangsanarak, Jaran; Namwongprom, Sirianong

doi:10.2147/jmdh.s92818

Cited by 15 publications

(21 citation statements)

References 22 publications

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“…Patients' characteristics were illustrated previously 22) . Briefly, there was a total of 3,120 infants which 1,534 infants (49%) were male, and 1,586 infants (51%) were female.…”

Section: Resultsmentioning

confidence: 99%

“…The details of study design, study population, and inclusion/exclusion criteria were showed and published elsewhere 22) . Briefly, data were collated from 3 tertiary hospital located in Northern part of Thailand including Uttaradit Hospital, Budhachinaraj Hospital and Sawanpracharuk Hospital.…”

Section: Methodsmentioning

confidence: 99%

“…Patients' characteristics and all relevant parameters were collected as presented previously 22) . For example, maternal diseases, family history of congenital sensorineural hearing loss, maternal age, Apgar score at 5 minutes, birth weight, intrauterine infection (maternal infection in uterus with cytomegalovirus, rubella, syphilis, herpes, or toxoplasmosis), craniofacial anomalies, mechanical ventilator use, meningitis, sepsis, ototoxic exposure, delivery route, hyperbilirubinemia.…”

Section: Methodsmentioning

confidence: 99%

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Hearing loss screening tool (COBRA score) for newborns in primary care setting

et al. 2017

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PurposeTo develop and evaluate a simple screening tool to assess hearing loss in newborns. A derived score was compared with the standard clinical practice tool.MethodsThis cohort study was designed to screen the hearing of newborns using transiently evoked otoacoustic emission and auditory brain stem response, and to determine the risk factors associated with hearing loss of newborns in 3 tertiary hospitals in Northern Thailand. Data were prospectively collected from November 1, 2010 to May 31, 2012. To develop the risk score, clinical-risk indicators were measured by Poisson risk regression. The regression coefficients were transformed into item scores dividing each regression-coefficient with the smallest coefficient in the model, rounding the number to its nearest integer, and adding up to a total score.ResultsFive clinical risk factors (Craniofacial anomaly, Ototoxicity, Birth weight, family history [Relative] of congenital sensorineural hearing loss, and Apgar score) were included in our COBRA score. The screening tool detected, by area under the receiver operating characteristic curve, more than 80% of existing hearing loss. The positive-likelihood ratio of hearing loss in patients with scores of 4, 6, and 8 were 25.21 (95% confidence interval [CI], 14.69–43.26), 58.52 (95% CI, 36.26–94.44), and 51.56 (95% CI, 33.74–78.82), respectively. This result was similar to the standard tool (The Joint Committee on Infant Hearing) of 26.72 (95% CI, 20.59–34.66).ConclusionA simple screening tool of five predictors provides good prediction indices for newborn hearing loss, which may motivate parents to bring children for further appropriate testing and investigations.

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“…Patients' characteristics were illustrated previously 22) . Briefly, there was a total of 3,120 infants which 1,534 infants (49%) were male, and 1,586 infants (51%) were female.…”

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Hearing loss screening tool (COBRA score) for newborns in primary care setting

et al. 2017

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“…They mentioned that, although the causes of UHL are not well-known, the toxic effects of aminoglycoside antibiotics on cochlear hair cells have been identified as a risk factor [ 17 ]. However, the impact of ototoxic treatment on hearing loss development in newborns is controversial [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown a number of risk factors for congenital hearing loss, including birth weight less than 1,250 grams, prematurity, hypoxia, Apgar score less than three and six in 1 and 5 minutes, respectively, seizures, ventilation, meningitis, jaundice, asphyxia, hypoglycemia, and treatment with aminoglycosides and furosemide. However, there are some newborns with hearing loss and without any known risk factors [9][10][11]. Therefore, hearing screening of all newborns is necessary to avoid negative outcomes of hearing loss for the children and their families.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Hearing Screening: Prevalence of Unilateral and Bilateral Hearing Loss and Associated Risk Factors

Sabbagh¹,

Amiri²,

Khorramizadeh³

et al. 2021

Cureus

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Introduction: Newborn hearing screening is essential for early identification of hearing loss to decrease the adverse effects of hearing loss. The objective of this study was to determine the prevalence of hearing loss and risk factors of congenital hearing loss in newborns.Methods: In this analytical case-control study, a hearing screening test was performed for all newborns aged 3-14 days.Results: Of 5,500 newborns evaluated, 24 newborns had hearing loss. The prevalence of hearing loss was 4.36 per 1,000. Of 24 hearing-impaired newborns, 15 had bilateral hearing loss (BHL) (62.5%) and nine had unilateral hearing loss (UHL) (37.5%). Among the neonates with hearing loss, the prevalence of hearing loss was higher (77.8%) in the right ear. The main risk factors identified in this study were low gestational age (P=0.001), hospitalization in the neonatal intensive care unit (NICU) ( P=0.008), exposure to ototoxic drugs (P=0.001), gestational diabetes P=0.01), craniofacial anomalies (P=0.01), convulsion (P=0.03), consanguineous marriage of parents (P=0.001), low birth weight (P=0.01), and hyperbilirubinemia (P=0.001). Conclusion:The prevalence of hearing loss was higher in the right ear than in the left ear. NICU stay, use of ototoxic drugs, low gestational age (<35 weeks), gestational diabetes, craniofacial anomalies, convulsion, consanguineous marriage of parents, low birth weight, and hyperbilirubinemia were significant risk factors for congenital hearing loss in studied newborns.

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ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death

et al. 2022

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Aminoglycoside antibiotics are lifesaving medicines, crucial for the treatment of chronic or drug resistant infections. However, aminoglycosides are toxic to the sensory hair cells in the inner ear. As a result, aminoglycoside-treated individuals can develop permanent hearing loss and vestibular impairment. There is considerable evidence that reactive oxygen species (ROS) production and the subsequent phosphorylation of c-Jun N-terminal kinase (JNK) and P38 mitogen-activated protein kinase (P38) drives apoptosis in aminoglycoside-treated hair cells. However, treatment strategies that directly inhibit ROS, JNK, or P38 are limited by the importance of these molecules for normal cellular function. Alternatively, the upstream regulator apoptosis signal-regulating kinase 1 (ASK1/MAP3K5) is a key mediator of ROS-induced JNK and P38 activation under pathologic but not homeostatic conditions. We investigated ASK1 as a mediator of drug-induced hair cell death using cochlear explants from Ask1 knockout mice, demonstrating that Ask1 deficiency attenuates neomycin-induced hair cell death. We then evaluated pharmacological inhibition of ASK1 with GS-444217 as a potential otoprotective therapy. GS-444217 significantly attenuated hair cell death in neomycin-treated explants but did not impact aminoglycoside efficacy against P. aeruginosa in the broth dilution test. Overall, we provide significant pre-clinical evidence that ASK1 inhibition represents a novel strategy for preventing aminoglycoside ototoxicity. Key messages • ASK1 is an upstream, redox-sensitive regulator of P38 and JNK, which are known mediators of hair cell death. • Ask1 knockout does not affect hair cell development in vivo, but significantly reduces aminoglycoside-induced hair cell death in vitro. • A small-molecule inhibitor of ASK1 attenuates neomycin-induced hair cell death, and does not impact antibiotic efficacy in vitro. • ASK1 may be a novel molecular target for preventing aminoglycoside-induced hearing loss.

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Risk factors for hearing loss in infants under universal hearing screening program in Northern Thailand

Cited by 15 publications

References 22 publications

Hearing loss screening tool (COBRA score) for newborns in primary care setting

Hearing loss screening tool (COBRA score) for newborns in primary care setting

Neonatal Hearing Screening: Prevalence of Unilateral and Bilateral Hearing Loss and Associated Risk Factors

ASK1 is a novel molecular target for preventing aminoglycoside-induced hair cell death

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