Risk Factors for Hearing Loss in Children following Bacterial Meningitis in a Tertiary Referral Hospital

Karanja, Benson Wahome; Oburra, Herbert; Masinde, Peter; Wamalwa, Dalton

doi:10.1155/2013/354725

Cited by 20 publications

(16 citation statements)

References 20 publications

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“…In a study in Kenya [ 9 ] and many other African countries [ 10 – 14 ], it was observed that there was a high prevalence of sensorineural hearing loss amongst children treated for bacterial meningitis ( Table 1 ). Children living in developing countries who fail to get vaccinated are at a greater risk of developing hearing loss sequel to bacterial meningitis infection [ 15 ].…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Genetics of hearing loss in africans: use of next generation sequencing is the best way forward

Lebeko¹,

Bosch²,

Noubiap³

et al. 2015

Pan Afr Med J

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Hearing loss is the most common communication disorder affecting about 1-7/1000 births worldwide. The most affected areas are developing countries due toextensively poor health care systems. Environmental causes contribute to 50-70% of cases, specifically meningitis in sub-Saharan Africa. The other 30-50% is attributed to genetic factors. Nonsyndromic hearing loss is the most common form of hearing loss accounting for up to 70% of cases. The most common mode of inheritance is autosomal recessive. The most prevalent mutations associated with autosomal recessive nonsyndromic hearing loss (ARNSHL) are found within connexin genes such as GJB2, mostly in people of European and Asian origin. For example, the c.35delG mutation ofGJB2 is found in 70% of ARNSHL patients of European descentand is rare in populations of otherethnicities. Other GJB2 mutations have been reported in various populations. The second most common mutations are found in theconnexin gene, GJB6, also with a high prevalencein patients of European descent. To date more than 60 genes have been associated with ARNSHL. We previously showed that mutations in GJB2, GJB6 and GJA1 are not significant causes of ARNSHL inpatients from African descents, i.e. Cameroonians and South AfricansIn order to resolve ARNSHL amongst sub-Saharan African patients, additional genes would need to be explored. Currently at least 60 genes are thought to play a role in ARNSHL thus the current approach using Sanger sequencing would not be appropriate as it would be expensive and time consuming. Next Generation sequencing (NGS) provides the best alternative approach. In this review, we reported on the success of using NGSas observed in various populations and advocate for the use of NGS to resolve cases of ARNSHL in sub-Saharan African populations.

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Section: Current Status Of Knowledgementioning

confidence: 99%

Genetics of hearing loss in africans: use of next generation sequencing is the best way forward

Lebeko¹,

Bosch²,

Noubiap³

et al. 2015

Pan Afr Med J

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“…In the same way, in the case of meningitis, the close anatomical relationship with the cranial cavity plays a key role. 12 In cases of postmeningitis bacterial deafness, cVEMPs were induced in 0% of ears, while the response rate was of 50% in the deafness of viral origin. In order to obtain a greater level of significance, these data require a greater sample.…”

Section: Discussionmentioning

confidence: 98%

“…For the division into subgroups we relied on previous studies in the literature. [12][13][14][15][16] In the cases of HL due to a bacterial-viral cause, it is easier to find a concurrent vestibular disorder to a cochlear deficit, because of the close anatomical relationship that occurs between the two organs and the similarity of the receptor cells inside them. In the same way, in the case of meningitis, the close anatomical relationship with the cranial cavity plays a key role.…”

Section: Discussionmentioning

confidence: 99%

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Application of Cervical Vestibular-Evoked Myogenic Potentials in Adults with Moderate to Profound Sensorineural Hearing Loss: A Preliminary Study

Ciodaro

Freni

Alberti

et al. 2020

Int Arch Otorhinolaryngol

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Introduction The cochlea and the vestibular receptors are closely related in terms of anatomy and phylogeny. Patients with moderate to profound sensorineural hearing loss (MPSHL) should have their vestibular organ functions tested. Objective To evaluate the incidence of vestibular abnormalities in patients with MPSHL and to study the correlation between the etiology of hearing loss (HL) and a possible damage to the labyrinth. Methods A case-control retrospective study was performed. In the case group, 20 adults with MPSHL of known etiology were included. The control group was composed of 15 adults with normal hearing. The case group was divided into 4 subgroups based on the etiology (bacterial meningitis, virus, vascular disease, congenital). Cervical vestibular-evoked myogenic potentials (cVEMPs) were used to rate the saccular function and lower vestibular nerve. Results The study was performed in 70 ears, and it highlighted the presence of early biphasic P1-N1 complex in 29 (71.5%) out of 40 ears in the study group, and in all of the 30 ears in the control group (p = 0.001). Regarding the presence or absence of cVEMPs among the four subgroups of patients with MPSHL, the data were statistically significant (p < 0.001). The comparison between the latencies and amplitude of P1-N1 in case and control groups from other studies and in the four subgroups of cases in the present study did not detect statistically significant differences. Conclusion The present study demonstrates that patients with MPSHL have a high incidence of damage to the labyrinthine organs, and it increases the current knowledge about the etiopathogenesis of sensorineural HL, which is often of unknown nature.

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“…[12] Among a cohort of meningitic children in Kenya, 43.4% presented with SNHL post meningitis, of whom 61% had mild to moderate hearing loss and 38.7% severe to profound loss. [13] …”

Section: Hearing Function and Neurological Disordersmentioning

confidence: 99%

Audiological findings in a group of neurologically compromised children: A retrospective study

2016

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Risk Factors for Hearing Loss in Children following Bacterial Meningitis in a Tertiary Referral Hospital

Cited by 20 publications

References 20 publications

Genetics of hearing loss in africans: use of next generation sequencing is the best way forward

Genetics of hearing loss in africans: use of next generation sequencing is the best way forward

Application of Cervical Vestibular-Evoked Myogenic Potentials in Adults with Moderate to Profound Sensorineural Hearing Loss: A Preliminary Study

Audiological findings in a group of neurologically compromised children: A retrospective study

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