Risk factors for human papillomavirus infection among women in Portugal: The CLEOPATRE Portugal Study

Pista, Ângela; Oliveira, Carlos; Cunha, Maria João; Paixão, Maria Teresa; Real, O

doi:10.1016/j.ijgo.2012.03.028

Cited by 27 publications

(42 citation statements)

References 17 publications

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“…From the positive samples for HPV, the vast majority (about 90%) had HPV considered high-risk/probable high-risk, which may be due to the fact that a large number of viruses are considered high-risk or to the fact that the technique used detect more high-risk HPV than low-risk HPV. As observed in other studies [5][6][7][24][25][26], from the women infected with high-risk/probable high-risk HPV, the HPV16 was the most frequent virus, followed by HPV31, HPV51, and HPV56. Also, as shown previously [25], from the women infected with low-risk HPV, HPV42 was the most prevalent.…”

Section: Discussionsupporting

confidence: 75%

“…Compared with the literature, these values fall within the expected range of HPV prevalence in the world population that varies between 6.1% and 35.5% [6,23], but is higher than the Portuguese estimated prevalence, which is, according with the CLEOPATRE Portugal study, 19.4% [7]. From the positive samples for HPV, the vast majority (about 90%) had HPV considered high-risk/probable high-risk, which may be due to the fact that a large number of viruses are considered high-risk or to the fact that the technique used detect more high-risk HPV than low-risk HPV.…”

Section: Discussionsupporting

confidence: 50%

“…The prevalence of HPV in the world population is estimated on a range varying between 6.1% and 35.5% [6]. In Portugal, the prevalence of HPV infection is 19.4% [7].…”

Section: Introductionmentioning

confidence: 99%

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The cytology and DNA detection by the PapilloCheck® test in the diagnosis of human papillomavirus infection

Vieira

Almeida

2013

European Journal of Microbiology and Immunology

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The aim of this study was to make a comparison between the results obtained by cytologies and by the detection and genotyping of human papillomavirus (HPV) DNA in the screening of cervical cancer. In this study, there were 994 samples used from human females. These were obtained from liquid-based preparations. The samples were analyzed by cytological technique and by the detection of HPV DNA using the PapilloCheck ® Test. The HPV was detected in 28% of the samples. Most of the cytology lesions appeared in HPV positive samples and, within these, the most serious injuries occurred mostly in samples with multiple HPV infections. The results indicate that, in general, there is a correlation between the detection of HPV DNA and cytology. However, there were some cases that emphasize the limitations of both diagnosis methods (27% cases with viral HPV DNA positive and normal cytologies and about 2% of cytological lesions detected in samples HPV negatives). It is possible to conclude that none of the two techniques is enough by itself and should be applied together in order to increase the accuracy of cervical cancer screening.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 50%

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The cytology and DNA detection by the PapilloCheck® test in the diagnosis of human papillomavirus infection

Vieira

Almeida

2013

European Journal of Microbiology and Immunology

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“…In general women who smoke are more frequently found hrHPV positive compared to non-smokers according to a study conducted in Greece [5], the main site of the presented study too, as well as according to other studies in different countries [6,[12][13][14][15]. Moreover, the intensity of smoking seems to play a role in the risk of being hrHPV positive, as it has been shown by a pooled IARC analysis [16], and by the Greek study too [5].…”

Section: Discussionsupporting

confidence: 73%

“…Smoking has been shown to be a factor associated to a higher probability of hrHPV infection by studies based on hrHPV DNA detection [5][6][7]. However, persistent hrHPV infection, characterized by the expression of E6 and E7 oncoproteins, which play a crucial role in HPV-related carcinogenesis [8], has not yet been studied thoroughly concerning probable associations to smoking.…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking Promotes Infection of Cervical Cells by High-Risk Human Papillomaviruses, but not Subsequent E7 Oncoprotein Expression

Chatzistamatiou

Moysiadis

Vryzas

et al. 2018

Preprint

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Persistent cervical infection with high-risk Human papillomaviruses (hrHPVs) is a necessary, but not sufficient, condition for the development of cervical cancer. Therefore, there are other co-factors facilitating the hrHPV carcinogenic process, one of which is smoking. In order to assess the effect of smoking on high-risk (hr) HPV DNA positivity and on the expression of HPV E7 oncoprotein, as a surrogate of persistent hrHPV infection, we used data from women recruited for the PIPAVIR project, which examined the role of E7 protein detection in cervical cancer screening. Women were tested for hrHPV DNA, using Multiplex Genotyping and E7 protein, using a novel sandwich ELISA method, and gave information on their smoking habits. Among 1473 women, hrHPV prevalence was 19.1%. The odds ratio (OR) for hrHPV positivity of smokers compared to non-smokers was 1.785 (95%CI: 1.365-2.332, p<0.001). The ORs for E7 positivity, concerning hrHPV positive women, ranged from 0.720 to 1.360 depending on the E7 detection assay used, but this was not statistically significant. Smoking increases the probability of hrHPV infection, and smoking intensity is positively associated to this increase. Smoking is not related to an increased probability of E7 protein positivity for hrHPV positive women.

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Potential impact of nonavalent HPV vaccine in the prevention of high‐grade cervical lesions and cervical cancer in Portugal

Pista¹,

Oliveira²,

Lopes³

et al. 2017

Intl J Gynecology & Obste

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Risk factors for human papillomavirus infection among women in Portugal: The CLEOPATRE Portugal Study

Abstract: National Commission of Data Protection (CNPD) registration number 5346/2007; Sanofi Pasteur MSD study number HPV-E05.

Cited by 27 publications

References 17 publications

The cytology and DNA detection by the PapilloCheck® test in the diagnosis of human papillomavirus infection

The cytology and DNA detection by the PapilloCheck® test in the diagnosis of human papillomavirus infection

Cigarette Smoking Promotes Infection of Cervical Cells by High-Risk Human Papillomaviruses, but not Subsequent E7 Oncoprotein Expression

Potential impact of nonavalent HPV vaccine in the prevention of high‐grade cervical lesions and cervical cancer in Portugal

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