Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients

Armahizer, Michael; Howard, Amy Kruger; Seung, Hyunuk; Kalasapudi, Lakshman; Sansur, Charles A.; Morris, Nicholas

doi:10.1016/j.wneu.2020.11.107

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…TOL is a first-generation sulfonylurea and has been used less in clinical practice since 1994 in Shanghai owing to its serious side effects (liver damage). , Therefore, TOL was only detected in old refuse samples with landfill ages of 27 years (with a low detection frequency of 12% and is therefore not shown in Figure ). GLY and GLI are antidiabetic agents belonging to the second-generation sulfonylurea and are shown to be resistant to biodegradation. , GLY had several advantages (such as low cost, good hypoglycemic effect, and wide acceptance) but its side effect (e.g., severe hypoglycemia) inhibited its use. Thus, GLY has experienced a similar phase-out.…”

Section: Resultsmentioning

confidence: 99%

“…GLY and GLI are antidiabetic agents belonging to the secondgeneration sulfonylurea and are shown to be resistant to biodegradation. 50,51 GLY had several advantages (such as low cost, good hypoglycemic effect, and wide acceptance) but its side effect (e.g., severe hypoglycemia 52 ) inhibited its use. Thus, GLY has experienced a similar phase-out.…”

Section: Variation In Pharmaceutical Detection By Agementioning

confidence: 99%

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Estimating the Mass of Pharmaceuticals Harbored in Municipal Solid Waste Landfills by Analyzing Refuse Samples at Various Ages and Depths

Zhao

Lyu

et al. 2023

Environ. Sci. Technol.

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Pharmaceuticals have been detected at high concentrations in municipal solid waste (MSW) landfill leachates, which are recognized as an underestimated source of pharmaceutical residues in the environment. However, limited efforts have been made to characterize pharmaceuticals in MSW landfill refuse, which is also of significant concern given the potential long-term environmental impact. Herein, we excavated landfill refuse from six cells with landfill ages of 7−27 years in the largest MSW landfill in Shanghai (in each cell, landfill refuse was collected from different depths of 2−8 m) and analyzed samples for the presence of 55 pharmaceuticals, including antibiotics and non-antibiotics. The results reveal the presence of 42 pharmaceuticals in landfill refuse, with median concentrations ranging from 0.30 to 116 μg/kg. Antibiotic and non-antibiotic pharmaceuticals exhibited diverse concentration trends with age, related to changes in policy intervention and consumption over time. Different concentration variations of individual pharmaceuticals were observed in refuse samples excavated at different depths and positively correlated to their sorption ability. The mass of pharmaceuticals in the investigated landfill was estimated from the obtained concentrations to be 80−220 tons with 95% probability, based on Monte Carlo analysis. To the best of our knowledge, this study provides the first estimate of pharmaceutical mass in an MSW landfill. The results will be helpful for understanding the potential long-term environmental impact of pharmaceuticals in landfills.

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Section: Resultsmentioning

confidence: 99%

Section: Variation In Pharmaceutical Detection By Agementioning

confidence: 99%

Estimating the Mass of Pharmaceuticals Harbored in Municipal Solid Waste Landfills by Analyzing Refuse Samples at Various Ages and Depths

Zhao

Lyu

et al. 2023

Environ. Sci. Technol.

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“…The utility of oral glibenclamide is being evaluated in clinical trials of ischemic stroke ( NCT03284463 , SE-GRACE) and spinal cord injury ( NCT02524379 , SCING) [ 231 , 232 ]. In a retrospective review of oral glyburide (2.5 mg twice daily, 71 patients) hypoglycemia occurred in 23.9% of patients, with acute kidney injury and low body mass index being significant risk factors [ 233 ].…”

Section: Nextgen Emerging Targetsmentioning

confidence: 99%

Emerging therapeutic targets for cerebral edema

Jha

Raikwar

Mihaljević

et al. 2021

Expert Opinion on Therapeutic Targets

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Introduction: Cerebral edema is a key contributor to death and disability in several forms of brain injury. Current treatment options are limited, reactive, and associated with significant morbidity. Targeted therapies are emerging based on a growing understanding of the molecular underpinnings of cerebral edema. Areas Covered: We review the pathophysiology and relationships between different cerebral edema subtypes to provide a foundation for emerging therapies. Mechanisms for promising molecular targets are discussed, with an emphasis on those advancing in clinical trials, including ion and water channels (AQP4, SUR1-TRPM4) and other proteins/lipids involved in edema signaling pathways (AVP, COX2, VEGF, and S1P). Research on novel treatment modalities for cerebral edema [including recombinant proteins and gene therapies] is presented and finally, insights on reducing secondary injury and improving clinical outcome are offered. Expert Opinion: Targeted molecular strategies to minimize or prevent cerebral edema are promising. Inhibition of SUR1-TRPM4 (glyburide/glibenclamide) and VEGF (bevacizumab) are currently closest to translation based on advances in clinical trials. However, the latter, tested in glioblastoma multiforme, has not demonstrated survival benefit. Research on recombinant proteins and gene therapies for cerebral edema is in its infancy, but early results are encouraging. These newer modalities may facilitate our understanding of the pathobiology underlying cerebral edema.

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Glibenclamide

2021

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Risk Factors for Hypoglycemia with the Use of Enteral Glyburide in Neurocritical Care Patients

Cited by 4 publications

References 22 publications

Estimating the Mass of Pharmaceuticals Harbored in Municipal Solid Waste Landfills by Analyzing Refuse Samples at Various Ages and Depths

Estimating the Mass of Pharmaceuticals Harbored in Municipal Solid Waste Landfills by Analyzing Refuse Samples at Various Ages and Depths

Emerging therapeutic targets for cerebral edema

Glibenclamide

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