Risk Factors forAcinetobacter baumanniiNosocomial Bacteremia in Critically Ill Patients: A Cohort Study

García-Garmendia, José-Luis; Ortíz-Leyba, Carlos; Garnacho-Montero, José; Jiménez-Jiménez, F. J.; Pérez-Paredes, Carmen; Barrero-Almodóvar, A; Miner, Miguel Gili

doi:10.1086/322584

Cited by 192 publications

(75 citation statements)

References 39 publications

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“…The incidence of Acinetobacter blood stream infection in this study was 1.3%, this is a little lower than 2% reported by Michalopoulos and Falagas (2007) and 8.8% reported by Garcia-Garmendia et al (2001b) This difference may be due to the lower number of patients recruited in the study. Prior to the introduction of current advanced resuscitatory devices, Acinetobacter spp were mainly recovered from the urinary tract however with the advent of mechanical ventilation most of the organisms are now being isolated from respiratory tract specimens.…”

Section: Discussioncontrasting

confidence: 72%

“…baumannii, A. calcoaceticus and A. lwoffii are the Acinetobacter species most frequently reported in clinical literature (Garcia-Garmendia et al, 2001b). There is some data to suggest that the proportion of Intensive Care Unit (ICU)-acquired pneumonia cases being found to be due to A. baumannii is on the increase.…”

Section: Ajidmentioning

confidence: 99%

“…Acinetobacter infection in literature is associated with high morbidity, mortality and increased length of hospital stay especially amongst patients in ICU, this has been attributed to its ability to acquire and up regulate resistance genes (Garcia-Garmendia et al, 2001a).…”

Section: Ajidmentioning

confidence: 99%

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NOSOCOMIAL ACINETOBACTER INFECTIONS IN INTENSIVE CARE UNIT

Ugochukwu¹,

Adetona

Fowotade

et al. 2013

American Journal of Infectious Diseases

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Acinetobacter plays an important role in the infection of patients admitted to hospitals. Acinetobacter are free living gram-negative coccobacilli that emerge as significant nosocomial pathogens in the hospital setting and are responsible for intermittent outbreaks in the Intensive Care Unit. The aim of this study was to determine the prevalence of Acinetobacter in patients admitted into the Intensive Care Unit and determine their role in infections in the ICU. A total of one hundred patients were recruited for the study, catheter specimen urine, tracheal aspirate and blood culture were collected aseptically from the patients. The specimens were cultured on blood and MacConkey and the organisms identified using Microbact 12E (0xoid). The Plasmid analysis was done using the TENS miniprep method. Fourteen (14%) of the 100 patients recruited into the study, developed Acinetobacter infection. Acinetobacter spp constituted 9% of the total number of isolates. Twelve (86%) of the isolates were recovered from tracheal aspirate, 1(7%) from urine and 1(7%) from blood. All of the isolates harbor plasmids of varying molecular sizes. Ten of the fourteen Acinetobacter were isolated at about the same period of time in the ICU with 6(42.7%) having plasmid size in the 23.1kb band and all showed similar pattern revealing that the isolates exhibit some relatedness. The clonal nature of the isolates suggest that strict infection control practices must be adopted in ICU, also an antibiotic policy must be developed for the ICU to prevent abuse of antibiotics that may lead to selection of resistant bacteria.

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Section: Discussioncontrasting

confidence: 72%

Section: Ajidmentioning

confidence: 99%

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NOSOCOMIAL ACINETOBACTER INFECTIONS IN INTENSIVE CARE UNIT

Ugochukwu¹,

Adetona

Fowotade

et al. 2013

American Journal of Infectious Diseases

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“…Previous sepsis in ICU and the number of invasive procedures were also related to the development of A. baumannii bacteremia in this unit. 8 A. baumannii can rapidly acquire antimicrobialresistance genes and thus become multidrug resistant.…”

Section: Introductionmentioning

confidence: 99%

Acinetobacter baumannii bloodstream infections in a tertiary hospital: Antimicrobial resistance surveillance

Al-Mously¹

2013

Int. j. infect. control

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Nosocomial bacteremia caused by Acinetobacter baumannii is of increasing concern in critically ill patients. there is a world-wide increase in the emergence of multidrug-resistant (MDR) A. baumannii to antimicrobials. therefore we conducted this study to evaluate the resistance pattern of A. baumannii in patients with bacteremia. this is a retrospective study conducted in a tertiary hospital in Saudi Arabia. During the period from April 2006 till April 2010, data for A. baumannii isolated from blood were collected. Multidrug resistant A. baumannii was defined as resistance to three or more classes of antibiotics.We found 191 isolates of A. baumannii from blood. the majority of cases were reported in surgical ICU (40.8%). the highest resistance rates to antimicrobials were reported for cefepime (73.8%) and piperacillin / tazobactam (72.3%), followed by ciprofloxacin (68%), and gentamicin (66%). Resistance rates were also high to imipenem (61.3%) and meropenem (60.7%). low rates of resistance to colistin (0.5%) and to tigecycline (3.9%) were observed. MDR was observed in 132 (69%) of the A. baumannii isolates and 104 (78.8%) of these MDR strains showed sensitivity only to colistin and tigecycline.Bacteremia due to A. baumannii was the highest in surgical ICU. the emergence of MDR A. baumannii is increasing and the resistance rates to carbapenems are alarming. Urgent measures are in need to slow the development of MDR AB. We recommend encouraging clinicians for strict adherence to infection control Corresponding Author

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“…Acinetobacter enfeksiyonu için çalışmalarda belirlenen diğer temel risk faktörleri geniş spektrumlu antibiyotik kullanımı, öncesinde enfeksiyon, total parenteral beslenme ve invaziv prosedürlerin varlığı (periferik damar, arteryel ve santral venöz katater, mekanik ventilasyon, nazogastrik tüp, üriner katater) şeklinde belirtilmiştir (16)(17)(18)(19)(20) . Bizim de çalışmamızda saptadığımız risk faktörleri, öncesinde ve sonrasında kültürlerde üreme (Tablo 1), öncesinde antibiyotik kullanmı, idrar sondası, mekanik ventilasyon, nazogastrik sonda, total parenteral beslenme, santral venöz katater, transfüzyon öyküsü gibi invaziv prosedürler şeklinde saptandı.…”

Section: Discussionunclassified

Chracteristics of acinetobacter baumanii isolated patients with respiratory samples in intensive care unit

Özdemır¹,

Özdemir²

2016

Terh

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Results: During this period, Acinetobacter baumannii isolated in respiratory samples of 38 patients (female=16, male n=22). The mean age of the patients was 68.6±18.1 years, and mean duration of hospitalisation was 25.4±18.3 days. Acinetobacter baumannii could be isolated from the culture media of respiratory samples after an average of 13.4±9.4 days followin inoculation A total of 29 cases (76.3%) exited. The underlying diseases were evaluated, and most frequently hypertension, stroke, heart failure, diabetes and COPD were detected. Prior to antibiotic use, urinary catheter, mechanical ventilation, nasogastric tube, total parenteral nutrition, central venous catheter had been most frequently detected risk factors. APACHE 2 score of the patients at admission to the intensive care unit was 23.3±5.7. On culture antibiograms, highest susceptibility to colistin polymyxin, tobramycin, gentamicin, imipenem, ciprofloxacin was noted. Conclusion: As a result, in our intensive care unit high rates of mortality due to Acinetobacter baumanni were detected.

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Risk Factors forAcinetobacter baumanniiNosocomial Bacteremia in Critically Ill Patients: A Cohort Study

Cited by 192 publications

References 39 publications

NOSOCOMIAL <i>ACINETOBACTER</i> INFECTIONS IN INTENSIVE CARE UNIT

NOSOCOMIAL <i>ACINETOBACTER</i> INFECTIONS IN INTENSIVE CARE UNIT

Acinetobacter baumannii bloodstream infections in a tertiary hospital: Antimicrobial resistance surveillance

Chracteristics of acinetobacter baumanii isolated patients with respiratory samples in intensive care unit

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