Risk Factors for Incident Open-angle Glaucoma

Leske, M. Cristina; Wu, Suh‐Yuh; Hennis, Anselm; Honkanen, Robert; Nemesure, Barbara

doi:10.1016/j.ophtha.2007.03.017

Cited by 704 publications

(548 citation statements)

References 42 publications

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“…Since PXS has been linked to multiple pathological entities of the eye including glaucoma, cataract, perioperative complications during eye surgery [19][20][21][22][23][24] and postoperative complications after cataract surgery 25 , it is of utmost importance to recognize ocular manifestations of PXS. Pseudoexfoliation (PEX) at baseline was identifi ed as an independent risk factor for primary open-angle glaucoma (POAG) and relation between increased intraocular pressure (IOP) and PXS was established in diff erent studies 26,27 , suggesting obstruction of the aqueous humor outfl ow. Exposure to PXS and a mean IOP ≥25 mm Hg increases the risk of POAG 56-fold 28 , indicating a high prevalence of POAG in a population with a high prevalence of PXS.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Pavičić-Astaloš

Koluder

Knežević

et al. 2016

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A total of 5349 subjects aged 40 or above presenting for general ophthalmic examination were screened for pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Each patient underwent complete ophthalmologic examination including ocular history, visual acuity testing, slit-lamp examination, applanation tonometry, optic disc evaluation, visual fi eld analysis, and gonioscopy if glaucoma was suspected. Exclusion criteria were pseudophakic and/or aphakic patients of any age, patients with concomitant congenital eye disease, and patients with very dense ocular media opacities. Out of 5349 patients examined, there were 1994 (38.38%) males and 3201 (61.61%) females. Th e prevalence of pseudoexfoliation syndrome was 3.6% and primary open angle glaucoma 9.4%, out of which 23.6% with pseudoexfoliation glaucoma. Th e fi ndings of this study improve our knowledge of pseudoexfoliation syndrome and pseudoexfoliation glaucoma in Croatia, particularly in the northwest region.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Pavičić-Astaloš

Koluder

Knežević

et al. 2016

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“…Ocular hypertension (OHT) defines a non-pathologic health status with elevated intraocular pressure (IOP), but without evidence of the structural or functional damage found with glaucoma. Major risk factors for the pathogenesis of glaucoma include a family history of glaucoma, elevated IOP, age, myopia, thin cornea, diabetes as well as African-American, Afro-Caribbean, Asian or Hispanic ethnicity [5,6,7,8,9,10]. Further risk factors for disease progression of glaucoma include the type of glaucoma, pseudoexfoliation, bilateral disease, older age, as well as disc hemorrhages which are associated with a higher rate of disease progression [11].…”

Section: Introductionmentioning

confidence: 99%

Health- and Vision-Related Quality of Life in Patients with Ocular Hypertension or Primary Open-Angle Glaucoma

et al. 2013

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Background: The main objective of this analysis was to assess the impact of severity of disease on the quality of life (QoL) of patients with ocular hypertension (OHT) and early, moderate, or advanced primary open-angle glaucoma (POAG). Methods: This multicenter study was conducted at 2 university hospitals and 13 ophthalmology practices in Germany. QoL data were assessed by the Health Utility Index (HUI3) and the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). Results: 154 patients (17.5% OHT, 27.9% early, 22.7% moderate, and 31.8% advanced POAG) were included. The HUI3 scores for OHT, early, moderate, and advanced POAG were 0.87 ± 0.09, 0.85 ± 0.15, 0.75 ± 0.23, and 0.58 ± 0.32, respectively. Compared to a normal population matched by age and gender, for moderate and severe POAG a difference of -0.06 ± 0.24 and -0.19 ± 0.28, respectively, was observed. NEI-VFQ-25 scores illustrate different dimensions of the impact on QoL; reduced peripheral vision or difficulties to drive a car were more crucial to glaucoma patients than social factors. Conclusions: The key difference for QoL impairment in glaucoma lies between OHT/early POAG versus moderate/severe POAG, hence every possible effort needs to be made to prevent disease progression over this threshold.

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“…Apart from IOP, a variety of other systemic and ocular risk factors for glaucoma have been identified, such as heart disease [143], low systolic blood pressure and low ocular perfusion pressure [144]. A large number of studies, using different clinical techniques, have demonstrated reduced ONH BF in eyes with glaucoma when compared to normal eyes.…”

Section: Modifications Of Retinal Blood Flow In Ischemic Microangiopamentioning

confidence: 99%

Retinal Blood Flow Evaluation

Pournaras

Riva

2012

Ophthalmologica

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Much of our basic knowledge of retinal blood flow regulation is based on data obtained from animal experiments through the use of invasive techniques. However, during the last decades, major developments in the field of optics and lasers have led to a variety of noninvasive techniques, which have been applied to the human eye for the investigation of retinal hemodynamics, and more specifically the regulation of retinal blood flow in response to a number of physiological and pharmacological stimuli. The Retinal Vessel Analyzer has markedly simplified the measurement of the diameter of retinal vessels, as well as the change in this diameter evoked by various physiological stimuli (dynamic measurements). Bidirectional laser Doppler velocimetry allows the measurement of absolute red blood cell centerline velocity, which, when combined with the diameter allows the calculation of retinal blood flow in the main retinal vessels. Laser Doppler flowmetry and laser speckle flowgraphy are techniques that measure the velocities of blood in discrete areas of the retinal tissue microcirculation. Adding a scanning capability, a spatial map of velocities across the retinal tissue is obtained. The blue-field simulation technique allows the quantification of the velocity, number and velocity pulsatility of leukocytes moving in the retinal capillaries of the macular region. With color Doppler imaging, the peak systolic and end-diastolic values of blood velocity in the ophthalmic and central retinal artery are measured, from which a resistivity index is obtained. These techniques may help better understand the role of altered retinal blood flow and its regulation in the pathogenesis of retinal diseases of vascular origin.

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Risk Factors for Incident Open-angle Glaucoma

Cited by 704 publications

References 42 publications

Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Population of North-West Croatia Aged 40 and Over

Health- and Vision-Related Quality of Life in Patients with Ocular Hypertension or Primary Open-Angle Glaucoma

Retinal Blood Flow Evaluation

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