Risk factors for inflammatory bowel disease: A prospective multi-center study

Amarapurkar, Anjali D; Amarapurkar, Deepak; Rathi, Pravin; Sawant, Prabha; Patel, Nikhil D; Kamani, Praful; Rawal, Krishn Kant; Baijal, Rajiv; Sonawane, Ameya; Narawane, Nitin; Kolekar, S; Totla, Naveen

doi:10.1007/s12664-018-0850-0

Cited by 52 publications

(41 citation statements)

References 36 publications

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“…Theirs is a fascinating finding, but recent data have suggested that the disease does not necessarily favor urban areas. 5,6 Wherever the metals are coming from, this study strengthens the connection of IBD risk with the mothers of affected individuals. The finding of metals that can be tracked to the in utero state suggests that the offspring who will ultimately present with IBD and have high values of these metals are likely acquiring these metals from their mothers.…”

supporting

confidence: 62%

“…Regardless, smoking does not even seem to be associated with Crohn's disease in China or India where IBD is on the rise, likely in the absence of NOD2 mutations. 5,13 Torres et al 4 present the premise that "biomarkers are needed to identify persons at risk for developing inflammatory bowel diseases." Until the tools are available to truly prevent Crohn's disease evolution, at best we can say that biomarkers are needed to help expand our diagnostic armamentarium.…”

mentioning

confidence: 99%

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New Biomarkers for Crohn’s Disease

Bernstein

2020

Gastroenterology

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supporting

confidence: 62%

mentioning

confidence: 99%

New Biomarkers for Crohn’s Disease

Bernstein

2020

Gastroenterology

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“…Dietary habits differ between the SA sub-groups and might explain some of the observed differences. A recent study of IBD patients in India suggested vegetarianism maybe protective in this cohort[31]. As vegetarianism is higher in Gujarati populations (North Indians), who form the predominant ethnic group in North West London and Leicester, we would have expected a lower not higher UC incidence rates for these regions[32,33].…”

Section: Discussionmentioning

confidence: 85%

Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception epidemiology study

Misra

Limdi

Cooney

et al. 2019

WJG

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BACKGROUNDThe current epidemiology of inflammatory bowel disease (IBD) in the multi-ethnic United Kingdom is unknown. The last incidence study in the United Kingdom was carried out over 20 years ago.AIMTo describe the incidence and phenotype of IBD and distribution within ethnic groups.METHODSAdult patients (> 16 years) with newly diagnosed IBD (fulfilling Copenhagen diagnostic criteria) were prospectively recruited over one year in 5 urban catchment areas with high South Asian population. Patient demographics, ethnic codes, disease phenotype (Montreal classification), disease activity and treatment within 3 months of diagnosis were recorded onto the Epicom database.RESULTSAcross a population of 2271406 adults, 339 adult patients were diagnosed with IBD over one year: 218 with ulcerative colitis (UC, 64.3%), 115 with Crohn's disease (CD, 33.9%) and 6 with IBD unclassified (1.8%). The crude incidence of IBD, UC and CD was 17.0/100000, 11.3/100000 and 5.3/100000 respectively. The age adjusted incidence of IBD and UC were significantly higher in the Indian group (25.2/100000 and 20.5/100000) compared to White European (14.9/100000, P = 0.009 and 8.2/100000, P < 0.001) and Pakistani groups (14.9/100000, P = 0.001 and 11.2/100000, P = 0.007). The Indian group were significantly more likely to have extensive disease than White Europeans (52.7% vs 41.7%, P = 0.031). There was no significant difference in time to diagnosis, disease activity and treatment.CONCLUSIONThis is the only prospective study to report the incidence of IBD in an ethnically diverse United Kingdom population. The Indian ethnic group showed the highest age-adjusted incidence of UC (20.5/100000). Further studies on dietary, microbial and metabolic factors that might explain these findings in UC are underway.

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“…Amarapurkar A. et al reported that the VD constitutes a risk factor for CD and protects from UC [94]. The study does not show the impact of a vegetarian diet on the course of IBD.…”

Section: Vegetarian Dietsmentioning

confidence: 65%

Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease

et al. 2020

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Recent research studies have shown that vitamin C (ascorbic acid) may affect bone mineral density and that a deficiency of ascorbic acid leads to the development of osteoporosis. Patients suffering from an inflammatory bowel disease are at a risk of low bone mineral density. It is vital to notice that patients with Crohn’s disease and ulcerative colitis also are at risk of vitamin C deficiency which is due to factors such as reduced consumption of fresh vegetables and fruits, i.e., the main sources of ascorbic acid. Additionally, some patients follow diets which may provide an insufficient amount of vitamin C. Moreover, serum vitamin C level also is dependent on genetic factors, such as SLC23A1 and SLC23A2 genes, encoding sodium-dependent vitamin C transporters and GSTM1, GSTP1 and GSTT1 genes which encode glutathione S-transferases. Furthermore, ascorbic acid may modify the composition of gut microbiota which plays a role in the pathogenesis of an inflammatory bowel disease.

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Risk factors for inflammatory bowel disease: A prospective multi-center study

Abstract: This study highlights association between socioeconomic, dietary factors, appendectomy, and family history as risk factors for IBD.

Cited by 52 publications

References 36 publications

New Biomarkers for Crohn’s Disease

New Biomarkers for Crohn’s Disease

Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception epidemiology study

Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease

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