Risk Factors for Intracardiac Thrombosis in the Right Atrium and Superior Vena Cava in Critically Ill Neonates who Required the Installation of a Central Venous Catheter

Abstract

This study allowed us to identify several contributing factors to the development of intracardiac thrombosis in the RA and SVC related to the installation of a CVC in a subgroup of critically ill neonates. Multicenter and well-designed studies with a larger number of patients could help validate our findings and/or identify other risk factors that were not identified in the present study.

Ultrasound‐guided supraclavicular cannulation of left brachiocephalic versus right internal jugular vein: Comparative analysis of central venous catheter‐associated complications

“…The mean duration of surgery was 316 ± 133 minutes. Children were ventilated for a median of 0 [0, 2] days, and the length of duration stay on ICU was a median of 3.00 1,6 days (Table 1). No relevant bleeding was documented in association with the placement of the CVC, and no arterial punctures were noted.…”

“…Several studies have reported that CADVT occurs in approximately 15%–39% of pediatric patients with a CVC and the risk is particularly high in preterm infants and neonates 9,10 . It must be noted, that the inflammatory and immunosuppressive effects of cardiopulmonary bypass and major surgery may have a different impact on the occurrence of complications in such patients when compared with other conditions 5,6 . Furthermore, the question of the influence of the puncture site of a CVC on the development of CADVT for pediatric cardiac surgery patients has not been conclusively answered in studies.…”

Assessment of clinical characteristics and treatment outcomes of pediatric patients with intracardiac thrombosis: a single-center experience

“…Table 5 The analysis between the two groups endothelial cells, suppression of fibrinolysis with increased levels of plasminogen activator inhibitor-1 (PAI-1), and a decrease in inhibitory protein levels contribute to thrombus formation [20,21]. Infections have been reported as a risk factor in many studies [4,7,9,15,[22][23][24].…”

“…Saracco et al revealed in their study, in which they examined 75 neonates with thrombi, that 16% of thrombi were ICT [36]. Sepsis, CVC, CHD, prematurity, RDS, and gestational diabetes are the most significant risk factors [16,20,[22][23][24]36].…”

“…Saracco et al revealed in their study, in which they examined 75 neonates with thrombi, that 16% of thrombi were ICT [36]. Sepsis, CVC, CHD, prematurity, RDS, and gestational diabetes are the most significant risk factors [16,20,22–24,36]. There have been recent studies in which r-TPA has been successfully used in neonatal ICT treatment with increasing frequency and with fewer adverse effects, albeit it has been revealed that neonatal ICTs could be treated with the administration of anticoagulants without the need for thrombolytic therapy [14,16,22,24,36,37].…”