Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study

Zhao, Qian; Yang, Yan; He, Songwei; Wang, Xin-Tai; Liu, Chang

doi:10.12998/wjcc.v9.i22.6244

Cited by 10 publications

(15 citation statements)

References 26 publications

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“…Recently, Zhao et al . compared 60 children with IgAV who developed intussusception with those without intussusception and reported age at onset, not receiving glucocorticoid therapy within 72 h after the onset of GI symptoms, hematochezia and D‐dimer levels as risk factors for intussusception 8 . In our study, the time from the onset of the first symptom of IgAV to the onset of steroids was found to be a risk factor for the development of intussusception in patients with IgAV‐GI tract involvement.…”

Section: Discussionmentioning

confidence: 61%

“…Due to its rarity, there are few reports evaluating the factors associated with intussusception in IgAV and the course of the patient who develops intussusception. Age at onset of disease, time of initiation of steroid therapy, presence of hematochezia and D‐dimer levels have been reported as independent predictors of intussusception in children with IgAV 8 …”

Section: What Is Already Known On This Topicmentioning

confidence: 99%

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Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment

Acar¹,

Tekin²,

Güngörer³

et al. 2023

J Paediatrics Child Health

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Aim: To identify the risk factors associated with intussusception in children with immunoglobulin A vasculitis (IgAV)-gastrointestinal (GI) tract involvement and to evaluate the outcomes of medical treatment and surgical intervention and the course of patients with intussusception. Methods: This retrospective study was conducted in 157 patients under 18 years of age who were followed up with the diagnosis of IgAV-GI tract involvement between January 2015 and September 2022. The characteristics of the patients who developed intussusception were evaluated in detail. Results: One hundred and fifty-seven patients with GI tract involvement were included in the study. The mean age of patients with IgAV-GI tract involvement was 8.7 AE 3.7 years. The female-to-male ratio was 1:1.5. Intussusception was detected in 14 patients (8.9%). Two patients (14.3%) underwent surgery, and the remaining 12 patients (85.7%) had their medical therapy intensified. Patients with GI tract involvement were divided into two groups as with (n = 14) and without (n = 143) intussusception. There was a statistically significant difference between the groups in the time from the onset of the first symptom of IgAV to the onset of steroids (P = 0.001). There were no statistically significant differences between the groups in age at onset of IgAV, gender distribution, erythrocyte sedimentation rate and C-reactive protein levels. Conclusions: The time from the onset of the first symptom of IgAV to the start of steroids is a risk factor for the development of intussusception in patients with IgAV-GI tract involvement. In these patients, medical treatment usually reduces intussusception without the need for surgical intervention.

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Section: Discussionmentioning

confidence: 61%

Section: What Is Already Known On This Topicmentioning

confidence: 99%

Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment

Acar¹,

Tekin²,

Güngörer³

et al. 2023

J Paediatrics Child Health

View full text Add to dashboard Cite

show abstract

“…[ 22 ] A negative D-dimer, according to most doctors, is most valid and advantageous when performed on those who are at risk of thrombosis. [ 23 24 25 26 ]…”

Section: Discussionmentioning

confidence: 99%

Awareness on D-dimer assay among dental students

Anjum

Ahmed

Ganapathy

et al. 2022

Journal of Advanced Pharmaceutical Technology &Amp; Research

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D-dimer molecules are formed by the degradation of cross-linked fibrin during the process of fibrinolysis. The formation of D-dimer requires the activity of activated factor XIII (factor XIIIa), plasmin, and thrombin. To assess the awareness about D-dimer assay among dental students. A cross-sectional study was done among 100 dental practitioners through an online survey. The survey consisted of 10 semiclosed prevalidated and reliable questionnaires based on the knowledge, attitude, and practice of the dentists on D-dimer assay. Descriptive and inferential statistics were performed to report the responses of the participants. Most participants did not know what a D-dimer assay is (55%). Forty-six percent of participants responded that the D-dimer assay is used to rule out serious blood clots. Fifty-four percent of the participants responded that fibrin D-dimers are formed when fibrin strands are formed. The current study shows that the knowledge about D-dimer assay is more in CRRI than in participants of junior year of study. Thus, more rigorous educational programs should be initiated to further enrich the knowledge among dental students.

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“…In general, most intussusceptions can be categorized as primary or idiopathic, with thickened bowel wall lymphoid tissue (Peyer patches) acting as the lead point. Approximately 5–12% of intussusceptions are pathological, which usually present with different symptoms and are caused by conditions such as Meckel’s diverticula ( 4 ), intestinal polyps ( 5 , 6 ), intestinal duplication ( 7 ), allergic purpura ( 8 ) and some rare digestive tract malignant tumors ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Nomogram for Predicting Pathological Intussusceptions in Children Prior to Surgical Intervention

Duan

Liu

et al. 2022

Front. Pediatr.

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PurposeEstablish and validate a nomogram to help predict the preoperative risk of a pathological intussusception.MethodsA primary cohort of patients who underwent surgery for an intussusception were enrolled from one center, while a validation cohort consisted of patients from another center. Multivariate logistic regression analysis was used to identify the variables to build the nomogram. A calibration curve accompanied by the Hosmer-Lemeshow test was used to assess the calibration of the nomogram. To quantify the discrimination of the nomogram, Harrell’s C-index was calculated. The performance of the validated nomogram was tested in the external validation cohort. The logistic regression formulae created during the analysis of the primary cohort was applied to all patients in the external validation cohort, and the total points for each patient were calculated.ResultsThe primary cohort consisted of 368 patients and the validation cohort included 74. The LASSO logistic algorithm identified three (recurrence episodes, mass size, and infection history) out of 11 potential clinical variables as significantly predictive of a pathologic intussusception. The C-index for the predictive nomogram was 0.922 (95% CI, 0.885–0.959) for the primary cohort and 0.886 (95% CI, 0.809–0.962) for the validation cohort. The decision curve showed that if the threshold probability of a patient in the validation cohort was > 7%, then the nomogram was more beneficial than either indiscriminately treating all or none of the patients.ConclusionWe developed a nomogram based on clinical risk factors that could be used to individually predict pathological intussusceptions in children prior to surgical intervention.

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Risk factors for intussusception in children with Henoch-Schönlein purpura: A case-control study

Cited by 10 publications

References 26 publications

Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment

Intussusception as a rare manifestation of immunoglobulin A vasculitis: Risk factors and treatment

Awareness on D-dimer assay among dental students

Development and Validation of a Nomogram for Predicting Pathological Intussusceptions in Children Prior to Surgical Intervention

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