Risk Factors for Irritable Bowel Syndrome in Turkish Population

Abstract

According to our results, in patients complaining of IBS it is of importance to search for a food component. Clinical improvements can be observed after the introduction of an adequate exclusion diet.

A systematic review of the prevalence and risk factors of irritable bowel syndrome among medical students

“…The rates of IBS increased along with increasing stress levels. A Turkish case-control study (33) showed that depression among IBS cases was significantly much higher (38%) than among the controls (4%). Another recent study from Belgium reported an increased risk of patients with psychological co-morbidity to develop postinfectious IBS (PI-IBS) (34).…”

“…Similarly, Zhang et al (35) conducted a meta-analysis of the studies among the Chinese general population and reported that food allergy increased the liability of IBS (OR=2.80, 95% CI: 2.12-3.67). The Turkish case-control study reported that the skin prick test and the mean IgE positivity levels were significantly more among IBS cases than among their controls (33).…”

Discrepancies between the responses to skin prick test to food and respiratory antigens in two subtypes of patients with irritable bowel syndrome

“…Estimates of prevalence range from 9% to 22% depending upon population group studied [1][2][3][4][5][6][7] . The exact pathophysiology of IBS remains unknown, although various mechanisms including gastrointestinal dismotility and visceral hypersensitivity have been well studied in IBS [8][9][10] .…”

“…Another aspect of that study was the detection of a significant correlation between atopy and increased intestinal permeability, which suggests that at least a subset of IBS patients may have a systemic immunological disorder. Other studies have reported a correlation between asthma, food allergy and IBS [26][27][28][29] , but the role of allergic reactions in the pathophysiology of IBS remains controversial [7,13,27,[29][30][31] . We have previously observed that volunteers with a diagnosis of IBS have reported higher cutaneous reactivity to food antigens than to inhalant allergens, when compared to patients with functional dyspepsia and nor mal controls [30] .…”

“…Clinically, the frequency of IBS is associated with psychological stress, food intolerance (adverse reaction to a specific food or ingredient that is not immune mediated or associated with psychological phenomena), intestinal infections, and even previous abdominal surgery [3,7,12,[20][21][22][23][24][25] . Dunlop et al [16] have reported that patients with subtype D-IBS (pos-infectious and non-infectious origin) have a more pronounced permeability increase in the proximal intestine compared with controls and those with C-IBS.…”