Risk Factors for Ischemic Stroke: A Case Control Analysis

Sridharan, Ramesh

doi:10.1159/000110903

Cited by 52 publications

(43 citation statements)

References 7 publications

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“…2 In our study, we found that diabetes is mainly a risk factor for ischemic stroke as supported by previous studies. 4,15,32 In our study obesity was less (10.4%) as against 22.3% in Fabry study. 10 Obesity, both general and abdominal is associated with higher risk of stroke, which may be the cause of increased incidence of stroke in women 10 Dyslipidemia is an important risk factor for stroke in previous studies4, 10, 28, which is also shown in our study.…”

Section: Discussioncontrasting

confidence: 49%

Lifestyle risk factors of stroke in young Indians

2020

JCHM

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Introduction: Stroke is a leading cause of death and claims 6 million lives every year worldwide. Etiology of stroke is extremely diverse in the young, risk factors differ considerably in young adults compared to those in older individuals. Lifestyle related risk factors play significant role in causation of stroke. The most frequent modifiable lifestyle related risk factors are smoking, physical inactivity, arterial hypertension, diabetes, dyslipidemia, and obesity. Prevention of stroke in the young assumes paramount importance as it increases number of quality-adjusted life years (QALY) much more in young than in elderly population. Objectives: To study the different lifestyle related risk factors in patients of stroke in age group 15-49 years. Materials and Methods: Patients of stroke between ages 15-49 years, who reported to Outpatient Neurology Services or admitted to a tertiary care service hospital, were evaluated for various potential lifestyle related risk factors which were analysed in detail using SPSS 15.0. Results: Out of total 144 cases studied alcohol consumption was found in 70 (48.6%) cases, smoking was present in 36 (25%) cases, while 50 (34.7%) cases were hypertensive, 10 (6.9%) cases were diabetic, 15 (10.4%) were obese and dyslipidemia was found in 56 (38.8%); multiple risk factors were found in 22 (15.3%) cases. Conclusion: Amongst lifestyle related problems alcohol, smoking, hypertension, diabetes and dyslipidemia followed by obesity were important risk factors for strokes in young. Unhealthy life style not only leads to increased chances of stroke, but also carries higher all cause mortality after stroke. The need of immediate vigorous primary and secondary preventive measures targeting the lifestyle modifications and risk factor among young population in developing countries in inevitable.

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Section: Discussioncontrasting

confidence: 49%

Lifestyle risk factors of stroke in young Indians

2020

JCHM

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“…Three decades of research of this topic have yielded inconsistent results [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] and have led to sharply opposing viewpoints about the importance of circulating cholesterol in ischemic stroke. 10,20 -24 At least part of the controversy can be attributed to methodological shortcomings of previous work.…”

mentioning

confidence: 99%

Plasma Lipid Profile and Incident Ischemic Stroke

Shahar

Chambless

Rosamond

et al. 2003

Stroke

279

122

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Background and Purpose-The role of circulating lipids and lipoproteins in the pathogenesis of ischemic stroke remains uncertain despite 3 decades of research. We examined this issue in a large population-based cohort. Methods-Between 1987 and 1989, 14 175 middle-aged men and women, free of clinical cardiovascular disease, took part in the first examination of the Atherosclerosis Risk in Communities (ARIC) study cohort. Baseline measurements included plasma levels of LDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein A-1, and triglycerides and myriad risk factors for cardiovascular disease. The cohort was followed for cardiovascular disease end points. Results-Over an average follow-up of 10 years (142 704 person-years at risk), we documented clinical ischemic stroke in 305 participants (161 men and 144 women). After multivariable adjustment for stroke risk factors, categorical and spline regression analyses of the entire sample, as well as the sample of men alone, revealed weak and inconsistent associations between ischemic stroke and each of the 5 lipid factors. Among women, the most consistent findings were decreasing risk of ischemic stroke within the top half of the distribution of HDL cholesterol and increasing risk within the lower range of the triglyceride distribution. Conclusions-The relation of circulating cholesterol to ischemic stroke does not resemble its well-known relation to coronary heart disease. Either the pathogenesis of a substantial proportion of ischemic strokes does not involve classic atherosclerotic mechanisms, or the effect of plasma lipids on atherogenesis is substantially different in the intracranial vascular bed.

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“…16,17 Isolated systolic hypertension is also correlated with increased thickness and plaque formation of the internal carotid artery. 18 In our study, hypertension was most common risk factor (80%) followed by diabetes mellitus (60%). Chronic hypertension promotes atherosclerosis.…”

Section: Discussionmentioning

confidence: 51%