Risk Factors for Legionella Pneumonia in a Large Nationally-Representative Sample

Allgaier, J.; Lagu, Tara; Haessler, Sarah; Imrey, Peter B.; Deshpande, Abhishek; Guo, Ning; Rothberg, M.

doi:10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2151

Cited by 1 publication

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“…Considering the high mortality and morbidity associated with untreated LD, early diagnosis and prompt treatment with effective antibiotics are extremely crucial, together with appropriate clinical management of complications and underlying comorbidities should be prioritized for LD patients [72] . Given that LD does not present any defining clinical features, empiric antibiotic therapy is well justifiable for the initial management of all moderate-tosevere community-and nosocomial-acquired pneumonia prior to LD confirmation made from microbiological diagnosis.…”

Section: Clinical Manifestation and Management Of Legionella Pneumoniamentioning

confidence: 99%

Legionella pneumophila — The causative agent of Legionnaires’ disease

Tan¹,

Tee²,

Khan³

et al. 2021

Prog Micobes Mol Biol

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Over the years, Legionella pneumophila has increasingly become a public health threat that causes sporadic and epidemic community-acquired and nosocomial-acquired pneumonia. Thus, this review aims to discuss the current knowledge of L. pneumophila, focusing on the global epidemiology, clinical features, diagnosis and treatment of Legionnaires’ disease (LD). Legionella bacteria are Gram-negative rod-shaped bacteria that are ubiquitous in aquatic environments. L. pneumophila was first discovered in 1976 and recognized as the causative agent of LD. L. pneumophila is a facultative intracellular pathogen that infects and replicates within eukaryotic host cells such as macrophages and protozoan. Diagnosis of LD remains a significant challenge as the clinical manifestation of LD is hardly distinguishable from pneumonia caused by other respiratory pathogens. Therefore, early testing and appropriate treatment are keys to alleviating the rising morbidity and mortality caused by LD.

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Section: Clinical Manifestation and Management Of Legionella Pneumoniamentioning

confidence: 99%